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Pharmacological Characterisation Of Venoms From Australian Box Jellyfish
Funder
National Health and Medical Research Council
Funding Amount
$33,626.00
Summary
Australian box jellyfish are responsible for many stings in Australia every year. Years of scientific research have gone into studying how these venoms work however, their mechanism of action is still unknown. Most of these venoms cause cardiovascular effects in envenomed people. Our aim is to isolate and characterise these toxins in the venoms, this will hopefully allow us to then isolate their mechanism of action. Thus allowing for better management of accidental human envenomings.
Transient Receptor Potential Calcium Channels In Breast Cancer Cell Proliferation, Apoptosis And Invasiveness
Funder
National Health and Medical Research Council
Funding Amount
$104,018.00
Summary
Calcium is a highly regulated signal used by cells to control processes such as growth and division, cell death and motility. Calcium channels let calcium into the cells, and specific calcium channel types are overexpressed in cancers, including those of the prostate and breast. In this research, we will assess the role of specific calcium permeable channels known as TRPs in breast cancer and the consequences of their inhibition on breast cancer cell growth and survival.
An Investigation Into The Efficacy Of Medication Warnings About Driving
Funder
National Health and Medical Research Council
Funding Amount
$47,427.00
Summary
It is recognised that the impairing effects of psychotropic medications can have harmful effects on traffic safety, particularly in the case of sleep medications such as benzodiazepines, however the effectiveness of these labels is largely unknown. The PhD will evaluate two approaches to medication warnings used in Australia and France. Results will inform patient care and prescribing advice and labelling, and could support the adoption of the model European labelling.
The Role Of The Metabotropic Glutamate 5 And Adenosine 2A Receptors In Methamphetamine Addiction
Funder
National Health and Medical Research Council
Funding Amount
$92,673.00
Summary
Methamphetamine (METH) is a highly addictive drug for which there are currently no effective drug therapies. This project will examine two receptors, the metabotropic glutamate 5 and adenosine 2A receptors in METH addiction. It is expected that these receptors, or their combination, may decrease the desire to self administer METH or find the drug rewarding. This study will be conducted using rodents; however, the results could identify more effective drug targets for METH addiction in humans.