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To understand how Hendra virus multiplies in infected cells, we will investigate the structure of its replicative machinery. This will provide the basis for rational drug design increasing Australia’s preparedness against the emergence of Hendra-like viruses.
Harnessing Lipid-reactive Immunity To Combat Mycobacterium Tuberculosis Infection
Funder
National Health and Medical Research Council
Funding Amount
$341,458.00
Summary
Critcial to the survival of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB) is its unique waxy (lipid)-rich cell wall. This proposal aims to target components of its cell wall to devlop novel therapeutic strategies. Specifically, the Australian-Singapore alliance will examine how the immune system "sees" lipid based antigens from M. tuberculosis, and then will ultimately use this information towards the devlopment of novel lipid-based vaccines.
An Investigation Into The Neural Substrates Of Cognitive Deficits In Mild Cognitive Impairment, And The Mechanisms Of Action Of A Novel Treatment
Funder
National Health and Medical Research Council
Funding Amount
$574,644.00
Summary
Furthering our understanding of the brain mechanisms that underlie the deficits in memory, executive function, and language that occur with Mild Cognitive Impairment is vital for conceptualising the underlying disease processes, and for the development of targeted treatments. Hence, this project will conduct a comprehensive assessment of the brain’s electrical and metabolic responses during specialised cognitive tasks, whilst simultaneously investigating a possible treatment.
Genetic Biomarkers And Molecular Pathways For Migraine
Funder
National Health and Medical Research Council
Funding Amount
$273,988.00
Summary
Common migraine, is a frequent, debilitating and painful disorder that affects people during their most productive years (up to 25% of women and 8% of men). Our recent results indicate the presence of multiple genetic factors contributing towards migraine susceptibility. Utilising detailed migraine symptom and medication data, larger numbers of migraine cases and controls, and applying the latest genotyping and imputation technologies, we will identify novel genetic biomarkers and molecular path ....Common migraine, is a frequent, debilitating and painful disorder that affects people during their most productive years (up to 25% of women and 8% of men). Our recent results indicate the presence of multiple genetic factors contributing towards migraine susceptibility. Utilising detailed migraine symptom and medication data, larger numbers of migraine cases and controls, and applying the latest genotyping and imputation technologies, we will identify novel genetic biomarkers and molecular pathways for migraine.Read moreRead less
Discovering Novel Molecules That Regulate Axonal Degeneration.
Funder
National Health and Medical Research Council
Funding Amount
$588,622.00
Summary
The axon is the primary signaling component of every neuron and is essential for normal function. Axonal degeneration is a key early pathological hallmark of Alzheimer’s disease. We lack a basic understanding of molecules that regulate this process. Such knowledge is essential for the development of treatments and therapies for dementia and the preservation of healthy ageing. I aim to discover the molecules that regulate axonal degeneration and study their function.
Lewy Bodies In Patients With Dementia – Determining Common And Unique Mechanisms In Relation To Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$604,644.00
Summary
Alzheimer’s disease is the most common type of dementia but often has multiple mixed pathologies. For example, Alzheimer post mortem brains may have abnormal accumulation of Lewy bodies in certain parts of the brains, and could be diagnosed as Lewy body disease. This may represent a skewed representation of some dementia subtypes. This project will identify the biological determinants of dementia patients with Lewy body disease for better understanding and future therapeutic targeting.