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Molecular Analysis Of Endocarditis Causing Strains Of Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$110,960.00
Summary
"Staphylococcus aureus" or "Golden Staph” is one of the principal causes of infective endocarditis, the infection of the endocardial surfaces of the heart and heart valves that may result in valvular insufficiency and eventual heart failure. This work will define the molecular mechanisms that allow S. aureus to survive and persist on endocardial surfaces. Such insight may lead to new future treatment regimes for infective endocarditis.
Optimising Management Of Injection-related Infections In People Who Inject Drugs
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
People who inject drugs are a vulnerable group who are at increased risk of bacterial infections, which can lead to serious illness and death. This project aims to optimize management of bacterial infections in people who inject drugs. Measuring the current burden of infections, analysing different management strategies employed in hospitals and discussing attitudes and barriers to care with both healthcare workers and people who inject drugs will provide the evidence to optimize ongoing care.
Establishing The Use Of Bacterial Genomics In Australia
Funder
National Health and Medical Research Council
Funding Amount
$157,669.00
Summary
We propose to establish a set of fully assembled reference genomes through new technologies and methods to analyse data from high throughput genome sequencing of important bacterial pathogens in Australia. We aim to demonstrate the capabilities of genome sequencing in clinical situations by comparing the genomes from clinical bacterial isolates to the established and annotated reference genomes.
For Every Question, There Is An Answer: Application Of Genomic Sequencing And Functional Genomics For Disease Gene Discovery In Children With Orphan Phenotypes
Funder
National Health and Medical Research Council
Funding Amount
$99,682.00
Summary
My PhD study will look closely at the genes in a family to see what is different and whether this difference is the cause of rare health problems. I will focus on children with highly unique conditions in which intellectual disability/developmental delay is a key feature. My study is important because if I can find the exact cause of rare genetic conditions, then I hope to improve the welfare of patients and families affected by these types of conditions.
Analysis Of Atrial Electrical Remodelling In Patients With Paroxysmal And Persistent Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$127,516.00
Summary
I am a cardiologist undertaking further training in the management of electrical abnormalities of the heart. My research will focus on the mechanisms responsible for atrial fibrillation, the most common serious heart rhythm disorder. I intend to do this by examining the nature of the electrical activity in patients with atrial fibrillation and comparing this to electrical activity in patients without this disorder, who are undergoing treatment procedures for their electrical disorder.
Factors That Influence Disease Severity In Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$149,076.00
Summary
Tuberculosis (TB) is a major global health problem and is one of the leading causes of death from an infectious disease worldwide. The severity of disease that occurs with TB is dependent on many complex factors including the infected person’s immune system and factors related to the TB organism itself. This research will determine the key factors that cause severe disease in TB which will translate into improved care of TB patients and enhance further research in this field.
Understanding The Molecular Basis Of Inherent And Acquired Resistance To Targeted Therapies In Metastatic Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$107,750.00
Summary
Targeted therapies aim to block cancer growth by interfering with specific molecules needed for its development and progression. Targeted therapies have led to improved responses and survival in patients with metastatic colorectal cancer. However, not all patients benefit from these treatments, and most patients who do respond eventually develop resistance. The aim of this research is to understand the mechanisms of resistance to these treatments, in order to improve their use in patients.
The Characterisation Of The Functional Regions Of Sarcomeric Alpha-actinins And To Determine How The Absence Of Alpha-actinin-3 Influences Human Skeletal Muscle Function And Metabolism.
Funder
National Health and Medical Research Council
Funding Amount
$95,313.00
Summary
We are studying a muscle protein called a-actinin-3. This protein is absent in approximately one billion people worldwide. A-actinin-3 is associated with athletic performance. Our goal is to explore how the absence of a-actinin-3 influences human skeletal muscle function and metabolism. We will be studying a-actinin-3 deficiency using a mouse model.
The Importance Of RUNX3 In Preventing Gastrointestinal Diseases And Tumour Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Stomach cancer is the second leading cause of cancer-related deaths. It is estimated that in 2010, more than 1 million people will die of stomach cancer with an increase of 19%. Studies have revealed that RUNX3 has the ability to suppress the growth of stomach cancer. However the role of RUNX3 in preventing metastasis is yet unknown. Therefore, an understanding of the factors that govern metastasis will inform the design of effective therapies to prevent mortality which is high for this disease.