Determining The Bacterial Contributions To Tuberculosis And Identification Of Drug Targets
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Serious issues of drug resistance have emerged in tuberculosis prevention and are placing enormous pressure on global health systems. We have identified an enzyme of M. tuberculosis that is essential for its survival. This project will develop potent inhibitory compounds for this enzyme. Further, we will identify new drug targets through a screen to specifically identify the genes of the organism essential for its survival in the body. This information will be used to develop new TB drugs.
Mechanisms Of Disease Caused By Hospital-acquired Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$465,218.00
Summary
We are currently experiencing unprecedented levels of antibiotic resistance in human pathogens. Unfortunately, the drug development pipeline is drying up, with almost no novel therapeutic options expected in the near future. This proposal aims to identify the mechanisms by which the most important antibiotic-resistant human pathogens make us sick. The expected outcomes are the identification of new targets that may be amenable to future drug development. These targets are aimed at making the org ....We are currently experiencing unprecedented levels of antibiotic resistance in human pathogens. Unfortunately, the drug development pipeline is drying up, with almost no novel therapeutic options expected in the near future. This proposal aims to identify the mechanisms by which the most important antibiotic-resistant human pathogens make us sick. The expected outcomes are the identification of new targets that may be amenable to future drug development. These targets are aimed at making the organisms less capable of causing disease in humans.Read moreRead less
Bacterial Pathogenomics: Whole-genome Sequencing To Investigate Infection Transmission, Pathogenesis And Antibiotic Resistance
Funder
National Health and Medical Research Council
Funding Amount
$475,946.00
Summary
As bacterial superbugs – resistant to multiple antibiotics – dominate the headlines, the pipeline for new antibiotics has all but dried up. High-throughput DNA sequencing heralds a golden opportunity for infectious disease research. By studying the entire collection of genes - the genome - of large numbers of multidrug resistant bacterial strains, we aim to better understand the genetic changes that govern the emergence and global spread of superbugs and translate these findings into the clinic.
Structural Characterization Of A Novel AB5 Cytoxin - SubAB
Funder
National Health and Medical Research Council
Funding Amount
$210,760.00
Summary
The proposed research program, using a combinantion of structural biology and biophysical techniques will provide insight into the role of novel AB5 toxin from E. coli. This study will not only improve our fundamental understanding the mode of action of this toxin from this devastating pathogen, but could lead to the design of rational antimicrobials. The knowledge gained will increase Australian international research profile.
Understanding And Modulating Hyperinflammation Caused By Influenza Viruses
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
In humans, highly pathogenic influenza A virus (IAV) infections can be fatal, as the disease is untreatable with available vaccine or anti-viral drugs. My fellowship aims to advance our knowledge of the mechanisms by which the immune system induces and regulates inflammation during IAV infection, which can be both helpful and detrimental in fighting the infection. This is critical for identifying and developing new therapies for severe IAV infections in the future.
Targeting Bacterial ÏsuperbugsÍ By Innovative Combination Dosing Strategies And New Antibiotics
Funder
National Health and Medical Research Council
Funding Amount
$463,650.00
Summary
This research project will elucidate the mechanistic basis to optimally combine available beta-lactam antibiotics to prevent resistance of gram-negative bacterial ïsuperbugsÍ. These mechanistic insights will be utilised to develop novel antibiotics that are active against these multidrug-resistant bacteria. The interdisciplinary project will substantially contribute to solving the global crisis due to multidrug-resistant bacteria and inform the design of effective new antibiotics.