Discovery Early Career Researcher Award - Grant ID: DE200101832
Funder
Australian Research Council
Funding Amount
$425,941.00
Summary
Mechanisms of immune protection for infectious laryngotracheitis virus. This project aims to investigate the mechanisms of immune protection against infectious laryngotracheitis virus. This will be achieved by investigating the role of local and systemic immunity and the immune cells associated with long-term protection against disease. The mechanisms of protection against this virus remain unknown which impairs the development of efficacious vaccines. Expected outcomes of this project are a mor ....Mechanisms of immune protection for infectious laryngotracheitis virus. This project aims to investigate the mechanisms of immune protection against infectious laryngotracheitis virus. This will be achieved by investigating the role of local and systemic immunity and the immune cells associated with long-term protection against disease. The mechanisms of protection against this virus remain unknown which impairs the development of efficacious vaccines. Expected outcomes of this project are a more rational approach to vaccination resulting in the generation of more effective and safer vaccination strategies that should benefit our important poultry industry. Additionally, the new methodologies and knowledge on mucosal immune markers could be utilised for the study of other pathogens.Read moreRead less
New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput anal ....New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.
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Discovery Early Career Researcher Award - Grant ID: DE240100295
Funder
Australian Research Council
Funding Amount
$455,563.00
Summary
Unlocking the helminth ‘early infection gap’ using 3D cell culture models. This project aims to revolutionise the study of critical early host-parasite interactions using innovative 3D cell culture models, reducing our dependence on animal infections. Liver fluke is the most economically important zoonotic parasite of Australian livestock and is a significant contributor to global food insecurity. Due to the reliance of parasites on mammalian hosts to survive, very little is known about the earl ....Unlocking the helminth ‘early infection gap’ using 3D cell culture models. This project aims to revolutionise the study of critical early host-parasite interactions using innovative 3D cell culture models, reducing our dependence on animal infections. Liver fluke is the most economically important zoonotic parasite of Australian livestock and is a significant contributor to global food insecurity. Due to the reliance of parasites on mammalian hosts to survive, very little is known about the early infection process. Expected outcomes include new knowledge on key migratory stimuli and liver fluke biology. Benefits include the identification of drug targets and vaccine candidates for use in livestock via the development of animal-free in vitro screening platforms that will serve as a prototype for other parasites.Read moreRead less
Reverse chemical proteomics: harnessing yeast display for drug discovery. This project aims to develop a technique that can rapidly identify the cellular protein targets of biologically active natural products. This project expects to provide fundamental biological and chemical insights into Australia's unique biodiversity that will facilitate the development of new therapeutic agents and agrochemicals based on leads provided by Nature. Expected outcomes of this project include an optimised and ....Reverse chemical proteomics: harnessing yeast display for drug discovery. This project aims to develop a technique that can rapidly identify the cellular protein targets of biologically active natural products. This project expects to provide fundamental biological and chemical insights into Australia's unique biodiversity that will facilitate the development of new therapeutic agents and agrochemicals based on leads provided by Nature. Expected outcomes of this project include an optimised and validated platform technology for accelerating drug discovery and development. This should substantially reduce the costs associated with fighting human and animal diseases, leading to improved health, productivity and quality of life.Read moreRead less
The infectome of NSW dairy calves, a genomic microbial surveillance . Infectious diseases are the main cause of disease and mortality in calves. The knowledge of the diversity of infectious disease-causing agents in NSW dairy cattle is not comprehensive. Thus, the immediate goal of this proposal is to redress this knowledge gap using untargeted microbial genomic sequencing to characterise and identify known and emerging enteric and respiratory pathogens in dairy calves. We will determine the occ ....The infectome of NSW dairy calves, a genomic microbial surveillance . Infectious diseases are the main cause of disease and mortality in calves. The knowledge of the diversity of infectious disease-causing agents in NSW dairy cattle is not comprehensive. Thus, the immediate goal of this proposal is to redress this knowledge gap using untargeted microbial genomic sequencing to characterise and identify known and emerging enteric and respiratory pathogens in dairy calves. We will determine the occurrence and distribution of their microbial species across all NSW dairy regions. This will enable the Australian dairy industry to improve animal health and productivity, and diagnostic capacity, which will allow farmers to make informed management decisions about disease control strategies. Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100050
Funder
Australian Research Council
Funding Amount
$4,508,426.00
Summary
ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassi ....ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassing the interconnection between people, animals, plants, and their shared environment.
Expected outcomes of this collaborative program include a cohort of researchers trained in industry-relevant techniques, furnishing solutions to partner-defined AMR challenges, and providing significant benefits by positioning Australia as a global leader in reducing AMR.Read moreRead less