A one million year record of relative sea-level, climatic and environmental changes - Aeolianites of the southern Australian continental margin. This project will (1) further refine two dating methods that will revolutionize Australia's capacity to date geological and archaeological events; (2) ensure that Australia remains in the forefront in applied geochronology and that a sufficient level of technical expertise remains within the country; (3) examine the sensitivity of coastal environments t ....A one million year record of relative sea-level, climatic and environmental changes - Aeolianites of the southern Australian continental margin. This project will (1) further refine two dating methods that will revolutionize Australia's capacity to date geological and archaeological events; (2) ensure that Australia remains in the forefront in applied geochronology and that a sufficient level of technical expertise remains within the country; (3) examine the sensitivity of coastal environments to rapid climate and sea-level changes; (4) increase public awareness of the scientific basis for the unique nature of Australia's coastal landscapes; and (5) may also assist in the exploration of strategically important minerals. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101020
Funder
Australian Research Council
Funding Amount
$350,821.00
Summary
The geodynamics of past sea level changes. This project is designed to quantify the effect of flow deep within Earth’s interior on past sea-level changes and on the flooding history of Australia over the last 550 million years. The rise and fall of sea level has shaped our planet over time. This project plans to combine recent advances in tectonic reconstructions and dynamic Earth models with the global and Australian rock record. The intended outcome is to understand how the Earth’s surface is ....The geodynamics of past sea level changes. This project is designed to quantify the effect of flow deep within Earth’s interior on past sea-level changes and on the flooding history of Australia over the last 550 million years. The rise and fall of sea level has shaped our planet over time. This project plans to combine recent advances in tectonic reconstructions and dynamic Earth models with the global and Australian rock record. The intended outcome is to understand how the Earth’s surface is shaped by flow within its interior, and how these processes explain the sedimentary record. Project results have the potential to be used as an exploration tool to maximise Australia’s competitive advantage in exploring onshore sedimentary basins.Read moreRead less
Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entir ....Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entirely new exploration model for deepwater hydrocarbons, 2) provided new expertise and seabed maps for generating a superior marine naval defence capability.Read moreRead less
First Australians, Last Megafauna? Modern Approaches To A Prehistoric Puzzle. Animal species will be, and have been, threatened with extinction continuously through time. Understanding the possible role of people in these events and how climate change may have made some species more vulnerable to extinction than others is an important aspect of ongoing debate in our society. How these factors influenced the extinction process has implications for how we might manage our policies on land, conser ....First Australians, Last Megafauna? Modern Approaches To A Prehistoric Puzzle. Animal species will be, and have been, threatened with extinction continuously through time. Understanding the possible role of people in these events and how climate change may have made some species more vulnerable to extinction than others is an important aspect of ongoing debate in our society. How these factors influenced the extinction process has implications for how we might manage our policies on land, conservation, biodiversity, and 'at-risk' animal species. Additionally, the involvement of indigenous communities provides important employment and cultural exchange opportunities.Read moreRead less
Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students train ....Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students trained in advanced computational methods suitable for the evolving Australian oil and gas industry; and a software product that has high commericalisation potential. The project will transfer knowledge from European industry and universities to Australia and has applications for mineral prospectivity in sedimentary basins. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
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A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
Effect Of Sex Steroids, Inflammation, Environmental And Biopsychosocial Factors On Cardiometabolic Disease Risk In Men
Funder
National Health and Medical Research Council
Funding Amount
$1,817,271.00
Summary
Heart disease is more frequent and occurs at an earlier age in men than women. The reason is unknown. Apart from obesity and associated disturbances of metabolism, changes in sex hormones such as testosterone, together with the effects of inflammation may be important, and may in turn be affected by environment, lifestyle behaviours, and stress. To untangle these relationships, we will use cutting edge technology, in a large sample of men, in partnership with other international scientists.
A palaeoenvironmental reconstruction of Holocene coastal valley evolution in NSW: A magnetic, geochemical, sedimentological and microfossil investigation. Coastal environments are a critical interface between land and ocean. They are sensitive to sea level change and they can influence climate because they trap a large fraction of the carbon buried annually in the oceans. We propose an inter-disciplinary investigation to determine how NSW coastal environments responded to past climate change. Th ....A palaeoenvironmental reconstruction of Holocene coastal valley evolution in NSW: A magnetic, geochemical, sedimentological and microfossil investigation. Coastal environments are a critical interface between land and ocean. They are sensitive to sea level change and they can influence climate because they trap a large fraction of the carbon buried annually in the oceans. We propose an inter-disciplinary investigation to determine how NSW coastal environments responded to past climate change. This will help to understand factors such as flood chronologies and acid sulphate soil potential and to predict the response to these environments to future climate change. Coastal environments support an increasing global population that will benefit from a better understanding of processes and responses within this critical zone.Read moreRead less
Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle ....Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle and adipose tissue by stimulating the movement of a glucose transport protein from inside the cell to the cell surface (see http:--www.imb.uq.edu.au-groups-james-glut4 for an animated description of this process). The purpose of this proposal is to dissect the molecular mechanisms by which this glucose transporter can be held inside the cell in the absence of insulin and then allowed to be released from this site moving to the surface in the presence of insulin. Our studies over the past 5 years have brought us much closer to understanding this process in detail. The identification of the molecules responsible for this regulatory step will not only aid our understanding of this process but it will also provide a valuable target for development of therapeutic agents that can be used to combat insulin resistance.Read moreRead less