Bone Marrow Endothelial Stem Cells Have The Capacity To Form Both The Endothelial And Haemopoietic Hierarchies
Funder
National Health and Medical Research Council
Funding Amount
$1,452,856.00
Summary
Blood cell formation is hierarchically organised; with hemopoietic stem cells (HSC) responsible for producing mature circulating blood cells. HSC reside in marrow near blood vessel cells. Although these play a key role in HSC regulation their origin in adults is poorly understood. We have demonstrated the existence of adult marrow vessel stem cells at the apex of a parallel hierarchy. Our objective is to characterise these in mice and humans and determine their role in blood malignancies.
Production Of Large Scale Erythroid Progenitor Cultures From Human Embryonic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$396,718.00
Summary
Transfusion of fresh red blood cell units of the correct blood type into patients can be life saving. However, access to units of the correct blood type is often limited due to limited supply of donor blood and its short shelf life creating the need for a constant donor blood supply. We propose to develop a system that allows us to generate unlimited numbers of human red blood cells in a culture dish which we will derive from differentiating human embryonic stem cell lines.
Investigation Of Dok2 And Dok1 Adapter Proteins, In The Negative Regulation Of Integrin AIIbb3 Platelet Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$446,831.00
Summary
Blood platelets play a key role in blood clot formation, prevention of bleeding and are the principal elements contributing to thrombosis leading to heart attack and stroke. Numerous studies have defined pathways promoting platelet activity, however less is known about their negative regulation. In this grant we will examine the role for proteins, Dok2 and Dok1, in the negative regulation of platelets, hoping this leads to development of novel therapeutics for prevention of cardiac disease.
A Novel Point Of Care (PoC) Device For Predicting And Monitoring Bleeding And Clotting (haemostasis)
Funder
National Health and Medical Research Council
Funding Amount
$608,979.00
Summary
Manipulating the bleeding/clotting system is a critical but expensive part of modern medicine, eg some people need blood thinners while others can bleed too much. Thrombin generation is the ideal overall test for the bleeding/clotting of blood, but current methods have major problems. We developed and patented a test that deals with most of the problems. This proposal will create an assay that is easy for doctors to perform without a specialised laboratory.
Blood And Blood Product Transfusion In Trauma Resuscitation
Funder
National Health and Medical Research Council
Funding Amount
$98,431.00
Summary
Blood is an exceedingly scarce and expensive resource. Massive transfusions place enormous strains on blood banks. There is little consensus and a paucity of evidence on transfusion practice in major trauma. Trauma patients account for a significant proportion of all patients who receive transfusions. This project will assist with the development of more uniform guidelines for transfusion of blood products in major trauma patients based on the best evidence available and current practice.