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Understanding The Pathophysiology Of Schizophrenia, Major Depressive Disorder And Bipolar Disorder As A Basis For Improving Treatments
Funder
National Health and Medical Research Council
Funding Amount
$804,106.00
Summary
The Applicant seeks to understand the causes of the schizophrenia, bipolar disorder and major depressive disorder, which affect over 20% of the Australian population. This research is important as drug design, based on chemical remodelling, has not significantly advanced initial breakthroughs in treating psychiatric disorders and there is now a widespread belief that new drugs will only come from understand their causes.
Novel Therapies, Risk Pathways And Prevention Of Mood Disorders
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
Concordant with the NHMRC priorities, this fellowship will principally focus on the development of novel therapies for mood disorders. We have pilot data that the amino acid, N acetyl cysteine reduces symptoms in unipolar and bipolar disorder and schizophrenia. We will further delineate the spectrum of efficacy, mechanisms of action and tolerability profile of this and related agents. We also will study risk factors and pathways for the development of depression, to develop public health strateg ....Concordant with the NHMRC priorities, this fellowship will principally focus on the development of novel therapies for mood disorders. We have pilot data that the amino acid, N acetyl cysteine reduces symptoms in unipolar and bipolar disorder and schizophrenia. We will further delineate the spectrum of efficacy, mechanisms of action and tolerability profile of this and related agents. We also will study risk factors and pathways for the development of depression, to develop public health strategies.Read moreRead less
An inability to resist a temptation or repeated failures of self-regulation can lead to 'impulsive' and 'compulsive' behaviours that relate to a host of personal and social problems (eg., excessive eating, gambling, and substance use). Despite this, very little research has studied the neural and psychological underpinnings of these behaviours. My research will take advantage of recent innovations and approaches to fill this void and have implications for diagnosis and treatment.
Early Childhood Mental Health: Pathways, Treatment, Access, And Community Literacy.
Funder
National Health and Medical Research Council
Funding Amount
$849,540.00
Summary
Many causes, warning signs, and opportunities for intervention for mental health problems are evident in early childhood. This project will conduct research and innovative practice that will transform our understanding of mental health problems in early childhood, including improved understanding of the environmental/biological mechanisms, methods to best target and disseminate effective early intervention, and improve community literacy and reduce stigma for these children and their parents.
I am a neurochemist-clinical research scientist investigating the interaction between, in particular, brain monoaminergic activity, autonomic function and physiological responses. My studies are largely focussed on determining the aetiology and consequenc
Mental Health And Substance Use: Understanding, Preventing And Treating
Funder
National Health and Medical Research Council
Funding Amount
$268,065.00
Summary
Mental & substance use disorders account for more years of disability than any other disorder. In young adults the top 10 causes of burden of disease are dominated by mental and substance use disorders. I lead an international program of research in the combined areas of mental health & substance abuse, and am recognised as a leading international expert. My research aims to increase our understanding of drug & alcohol and mental disorders, prevent where possible and improve treatment responses.
Advancing Our Understanding Of The Genetics Of Psychiatric And Neurological Disease
Funder
National Health and Medical Research Council
Funding Amount
$687,975.00
Summary
Over the next five years I will use statistical genetics approaches to: (i) identify genetic variants influencing brain structure and characterise their effects on structures implicated in neurological disease; (ii) improve our understanding of the genetics of Attention Deficit Hyperactivity Disorder and its impact on Australian families, and (iii) investigate the relationship between Depression and Nausea and Vomiting during Pregnancy.
Optimising Benefits And Minimising Potential Harms Of Obesity Treatments
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
This work aims to find safe and more effective obesity treatments for the over 2.1 billion people worldwide with overweight or obesity. Severely energy restricted diets are currently the most effective dietary obesity treatment, but these are underutilized due to concerns about potential harms. This work will investigate using severe diets intermittently rather than continuously, as a means of enhancing their benefits of long-term weight/fat loss while also reducing potential harmful effects.
Innovative Models Of Early Intervention For Conduct Disorders In Children
Funder
National Health and Medical Research Council
Funding Amount
$826,854.00
Summary
Most mental health problems begin in childhood, and Oppositional-defiant and conduct problems are the most reliable precursor of adult mental health problems. The lifetime costs on public services for these children are large. Australia has no strategy for managing this problem, and urgently needs to develop evidence-based approaches. This program of research will develop improved methods for identifying, assessing and treating child conduct disorders as part of our national strategy for early i ....Most mental health problems begin in childhood, and Oppositional-defiant and conduct problems are the most reliable precursor of adult mental health problems. The lifetime costs on public services for these children are large. Australia has no strategy for managing this problem, and urgently needs to develop evidence-based approaches. This program of research will develop improved methods for identifying, assessing and treating child conduct disorders as part of our national strategy for early intervention for mental health.Read moreRead less
Assessing The Population Health Impact Of Illicit Drug Use: Prevalence, Trajectories, And Contributions To Disease Burden
Funder
National Health and Medical Research Council
Funding Amount
$714,745.00
Summary
This Fellowship comprises three programmes of work: 1. epidemiology of illicit drug use (including the natural history of use: incidence, prevalence, persistence, desistance and relapse), contribution to the burden of disease; 2. risk and resilience in young people: drug use, drug trajectories, and adult outcomes of drug use; 3.The use and misuse of pharmaceutical opioids: drivers, trajectories, and outcomes. This work will inform prevention, early intervention and treatment initiatives.