Manipulation of Biological Particles Using Dielectrophoresis. Dielectrophoretic manipulation and separation of particles has numerous biological and medical applications, e.g. identification and characterisation of individual cells, purification of cell subpopulations from mixture suspensions, etc. This research project aims to develop a high-efficiency and low-cost DEP device for bio-particle manipulation. It will contribute significantly to the advancements in the field of biological Micro-Ele ....Manipulation of Biological Particles Using Dielectrophoresis. Dielectrophoretic manipulation and separation of particles has numerous biological and medical applications, e.g. identification and characterisation of individual cells, purification of cell subpopulations from mixture suspensions, etc. This research project aims to develop a high-efficiency and low-cost DEP device for bio-particle manipulation. It will contribute significantly to the advancements in the field of biological Micro-Electrical-Mechanical-Systems (MEMS) and nanotechnology. Industry will benefit from the expertise on micro/nano-structures and micro/nano-manufacturing achieved by this project.Read moreRead less
Sequencing the mammalian transcriptome in toto. The mammalian genome projects have provided a huge leap forward for biological research by giving the framework to study genes on a global scale. This project will provide human genome project scale information for every major tissue in mammals and will provide the research community with a world class resource to further genomic research. It will also investigate parts of gene regulation which have been invisible to researchers in the past. Discov ....Sequencing the mammalian transcriptome in toto. The mammalian genome projects have provided a huge leap forward for biological research by giving the framework to study genes on a global scale. This project will provide human genome project scale information for every major tissue in mammals and will provide the research community with a world class resource to further genomic research. It will also investigate parts of gene regulation which have been invisible to researchers in the past. Discovering these rules will provide novel insights in pathology with a genetic component and provide a further boost to biotechnological approaches to obtain expression of specific sets of genes in model systems. Read moreRead less
Development of a light detection system for enhanced scanning electron microscopy imaging of fully hydrated biological specimens at room temperature. This project aims to develop instrumentation and techniques to image fully hydrated cellS for prolonged periods at room temperature in an environmental scanning electron microscope. Multiple fluorescent nano-particle labels will be used to image complex cellular structure and dynamics at ultra high spatial resolution. This innovative bio-imaging te ....Development of a light detection system for enhanced scanning electron microscopy imaging of fully hydrated biological specimens at room temperature. This project aims to develop instrumentation and techniques to image fully hydrated cellS for prolonged periods at room temperature in an environmental scanning electron microscope. Multiple fluorescent nano-particle labels will be used to image complex cellular structure and dynamics at ultra high spatial resolution. This innovative bio-imaging technique will be facilitated by the construction of a high speed light collection system that can efficiently operate at the pressures required to stablise water within the cell. Applications for this new bio-imaging technique will also be explored.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454249
Funder
Australian Research Council
Funding Amount
$157,004.00
Summary
Specialist Analysis Facility for the Development of New Nanotechnologies. Nanotechnology is a developing technology with a limited number of academic research groups working in this field. Advanced infrastructure is requested for the characterisation and analysis of novel polymers, nanomaterials and biomaterials. The specialist applications herein demand both characterisation and processing control at the nanoscopic level and will greatly enhance teaching and core research capability within Fl ....Specialist Analysis Facility for the Development of New Nanotechnologies. Nanotechnology is a developing technology with a limited number of academic research groups working in this field. Advanced infrastructure is requested for the characterisation and analysis of novel polymers, nanomaterials and biomaterials. The specialist applications herein demand both characterisation and processing control at the nanoscopic level and will greatly enhance teaching and core research capability within Flinders University and the University of South Australia. This equipment will allow the universities to carry out this research in a unique manner. Other researchers cannot offer the synergy of synthesis, processing and characterisation of nanomaterials and biomaterials as described in this project.Read moreRead less
Development of improved technologies for high throughput screening of potential disease susceptibility genes. This research is aimed at developing more efficient strategies to identify genes involved in common, human disorders. We aim to develop cost-effective, high throughput approaches for DNA extraction and preparation, accurately determining DNA concentration and quality and for undertaking extensive polymorphism genotyping and analysis. The suitability of equipment, analysis packages and so ....Development of improved technologies for high throughput screening of potential disease susceptibility genes. This research is aimed at developing more efficient strategies to identify genes involved in common, human disorders. We aim to develop cost-effective, high throughput approaches for DNA extraction and preparation, accurately determining DNA concentration and quality and for undertaking extensive polymorphism genotyping and analysis. The suitability of equipment, analysis packages and software, will be assessed and better technologies and packages developed. The study involves collaboration between a research centre with considerable expertise in molecular genetics and Corbett Research, a leader in the field of molecular equipment production. The development of better gene screening technologies has both molecular and commercial significance.Read moreRead less
Nanoscale Particle Control by Rigid Biomineralised Surfaces. The proposed research will increase understanding of the strategies diatoms use to sort particles. Our hypothesis is that in the process of understanding how these diatom surfaces control particles, blueprints for microfluidic devices will be identified. The appeal of diatoms goes beyond consideration of the geometrical patterning on their surfaces, because their frustules (the diatomic shells) are made primarily out of silica, a mater ....Nanoscale Particle Control by Rigid Biomineralised Surfaces. The proposed research will increase understanding of the strategies diatoms use to sort particles. Our hypothesis is that in the process of understanding how these diatom surfaces control particles, blueprints for microfluidic devices will be identified. The appeal of diatoms goes beyond consideration of the geometrical patterning on their surfaces, because their frustules (the diatomic shells) are made primarily out of silica, a material also used in nanofabrication. We expect that some of the strategies and patterns used by cells will be able to be directly transferred to microfluidics, and bypass years of empirical development in nanofabrication and lab-on-a-chip devices.Read moreRead less
New methods to complete the lipidomics puzzle: revealing the structural diversity of lipids by mass spectrometry. Lipid-related disorders such as obesity, diabetes and heart disease are reaching epidemic proportions in the western world. The integration of innovative techniques will provide Australia with unique capabilities to investigate these diseases and place Australia at the forefront of lipid research internationally.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775513
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Advanced Process Tomography Research Facility for Multiphase System Studies. The establishment of an advanced process tomography facility at UNSW has several important national benefits, including; increased capacity of the collaborating institutions to train highly qualified personnel to meet new and growing demands in the processing industries; the transfer of research-based cheap and efficient technologies to our industries to enhance their position in a competitive global market; the improve ....Advanced Process Tomography Research Facility for Multiphase System Studies. The establishment of an advanced process tomography facility at UNSW has several important national benefits, including; increased capacity of the collaborating institutions to train highly qualified personnel to meet new and growing demands in the processing industries; the transfer of research-based cheap and efficient technologies to our industries to enhance their position in a competitive global market; the improvement in our culture and living standards through superior and inexpensive food, biomedical, water, environmental, materials and military products; and the strengthening of Australian position, through international linkage projects, as a world leader in the development of novel processing technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454209
Funder
Australian Research Council
Funding Amount
$126,326.00
Summary
A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing. The carbohydrate moiety of glycoconjugates plays an important role in their function and metabolism. Advances in glycan analytical and oligosaccharide sequencing techniques offer tremendous potential for the application of glycobiology to biotechnology, cell biology and medicine. This application aims to establish a Glycobiology Facility dedicated to glycoconjugate analysis and oligosaccharide sequencing. Funds a ....A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing. The carbohydrate moiety of glycoconjugates plays an important role in their function and metabolism. Advances in glycan analytical and oligosaccharide sequencing techniques offer tremendous potential for the application of glycobiology to biotechnology, cell biology and medicine. This application aims to establish a Glycobiology Facility dedicated to glycoconjugate analysis and oligosaccharide sequencing. Funds are requested for state of the art HPLC equipment, associated equipment and reagents for glycan purification/labelling, and a staff member, that are all essential to establish this technology in Australia. The Facility will support $25 million of existing research; approximately half of which is derived from ARC.Read moreRead less