Discovery Early Career Researcher Award - Grant ID: DE220100311
Funder
Australian Research Council
Funding Amount
$383,982.00
Summary
Shining nanoparticles for single microRNA detection in microfluidics. This project aims to extensively study the interface between nanoparticles and nucleic acids. It sets out to produce a novel ultrasensitive high-performance biosensing platform that will combine luminescent nanoparticles with microfluidics in a digital assay. This portable platform will detect biological fingerprints, or microRNAs, at a single-molecule level, delivering unprecedented levels of sensitivity and specificity. The ....Shining nanoparticles for single microRNA detection in microfluidics. This project aims to extensively study the interface between nanoparticles and nucleic acids. It sets out to produce a novel ultrasensitive high-performance biosensing platform that will combine luminescent nanoparticles with microfluidics in a digital assay. This portable platform will detect biological fingerprints, or microRNAs, at a single-molecule level, delivering unprecedented levels of sensitivity and specificity. The multiplexed platform has the potential to benefit the biomedical research of microRNAs and opens up a genuine commercialisation potential for portable biosensing of nucleic acids.Read moreRead less
The colour of cellular aging: a deep probe of cellular processes. Understanding why we age and whether aging is preventable are profound research challenges, which must be first tackled at a cellular level. Building on our advances in non-invasive colour monitoring of cell function, this project aims to uncover intimate links between cellular processes and aging in cells that must survive for many decades such as oocytes and neurons. We will explore the tantalising possibility to rejuvenate such ....The colour of cellular aging: a deep probe of cellular processes. Understanding why we age and whether aging is preventable are profound research challenges, which must be first tackled at a cellular level. Building on our advances in non-invasive colour monitoring of cell function, this project aims to uncover intimate links between cellular processes and aging in cells that must survive for many decades such as oocytes and neurons. We will explore the tantalising possibility to rejuvenate such aged cells by interfering with molecular master switches of aging. A unique machine learning approach will be applied for finding the most effective interventions. The results will have broad impact beyond the science of aging, in the areas of female fertility, neurodegeneration and immunity.
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Rejuvenating adult stem cells. This project aims to uncover intimate links between metabolic regulation and longevity in adult stem cells, the source of all cells in the body. Understanding why we age and whether ageing is preventable are research challenges which must be first attacked at a cellular level. This project will try to rejuvenate aged stem cells by interfering with a prospective molecular master switch of aging and also develop an approach to identify and select youthful stem cells. ....Rejuvenating adult stem cells. This project aims to uncover intimate links between metabolic regulation and longevity in adult stem cells, the source of all cells in the body. Understanding why we age and whether ageing is preventable are research challenges which must be first attacked at a cellular level. This project will try to rejuvenate aged stem cells by interfering with a prospective molecular master switch of aging and also develop an approach to identify and select youthful stem cells. The results are expected to be important beyond informing the science of ageing, in the areas of tissue engineering, wound healing, embryology and cancer.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100092
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
X-ray induced photoacoustic nanoprobe: Break depth dependency of bioimaging. This project aims to develop a nanoprobe using an X-ray excited luminescence “nanolaser” as the local light source to activate coupled responsive photoacoustic sensors. In-situ imaging of specific biomarkers at the molecular level is key to understanding their roles in physiological and pathological processes, but current imaging techniques using fluorescent probes cannot detect biomarkers in deep tissues due to shallow ....X-ray induced photoacoustic nanoprobe: Break depth dependency of bioimaging. This project aims to develop a nanoprobe using an X-ray excited luminescence “nanolaser” as the local light source to activate coupled responsive photoacoustic sensors. In-situ imaging of specific biomarkers at the molecular level is key to understanding their roles in physiological and pathological processes, but current imaging techniques using fluorescent probes cannot detect biomarkers in deep tissues due to shallow light penetration. By capitalising on the tissue penetrating property of X-rays and acoustic waves and collecting acoustic waves as the read-out signal, real-time monitoring of biomarkers in deep tissues could be achieved, advancing detection technology for deep-tissue biomarkers.Read moreRead less