Characterization Of Novel, Colitis Associated Pathobionts To Identify Therapeutic Targets In The Host Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$684,609.00
Summary
Applying cutting edge methods to grow bacteria from the human gut, we have identified three species, two previously unknown, that are found in many inflammatory diseases including Inflammatory bowel disease, colorectal cancer and in cancer immunotherapy patients who experience colitis. By characterizing these bacteria and the immune response in human cells we are seeking to discover novel targetted methods to prevent colitis and gastrointestinal inflammation.
Integrated System Wide Characterization Of Microbiota And Host Factors Influencing Intestinal Colonization Resistance To The Healthcare Pathogen Clostridium Difficile
Funder
National Health and Medical Research Council
Funding Amount
$359,999.00
Summary
Naturally occurring bacteria play an important role in determining patient disease susceptibility, disease progression and ultimately, disease outcome. Over 1000 species of bacteria, contributing 10 times as many cells as found within a single individual. This project seeks to understand these communities, how they confer resistance to infection and how they can be manipulated, both naturally and through controlled introduction of bacteria to prevent disease or improve disease outcome.