New insulins for the improved management of diabetes. The prevalence of diabetes has increased dramatically over the past few decades and now this condition is widely considered the world’s fastest growing disease. New insulins with improved pharmacological and storage properties are desperately needed, and this project will work on chemical synthesis enabling designer insulins to be prepared for improved management of diabetes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100100
Funder
Australian Research Council
Funding Amount
$975,934.00
Summary
Multifunctional Platform for Chemical Manufacturing and Energy Materials. We aim to establish the first platform in Australia for the continuous production and in-situ characterisation of molecules and nanomaterials. This project expects to generate new knowledge in the area of functional materials using an interdisciplinary approach. The expected outcomes will be a unique analytical capability for rapid screening of synthetic and operational parameters, and unprecedented fundamental insight int ....Multifunctional Platform for Chemical Manufacturing and Energy Materials. We aim to establish the first platform in Australia for the continuous production and in-situ characterisation of molecules and nanomaterials. This project expects to generate new knowledge in the area of functional materials using an interdisciplinary approach. The expected outcomes will be a unique analytical capability for rapid screening of synthetic and operational parameters, and unprecedented fundamental insight into chemical reactions to inform the design and development of sustainable chemical processes. This proposal will provide significant benefits to cutting-edge research in catalysis, polymer engineering, separation science, CO2 capture and organic synthesis, to positively impact on the energy-manufacturing-environment nexus.Read moreRead less
We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately exp ....We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately explore the relationship between prothesis wear and PO, or the progression of PO, because of a lack of techniques to image and measure the volume of PO around metal prosthesis components. We have developed a means to accurately and reproducibly measure the volume of bone loss, using CT, and will do so longitudinally in joint replacement patients to obtain the first information about the progression of PO. New computer based methods will be used concurrently to relate prosthesis wear and migration parameters to PO. Patients who come to surgery for replacement of failed prostheses will be investigated further by analysis of the tissues involved in the bone loss around prostheses. Basic science experiments will seek to understand the underlying causes of PO and the findings will be important in interpreting the clinical results. An animal model will be used to seek approaches to inhibiting the pathological response to wear particles. The significance of these studies is that they will lead to improved outcomes for joint replacement patients, increasing the interval to revision surgery, which is both extremely costly and brings an attendant morbidity and mortality.Read moreRead less
ARC Centre of Excellence for Green Electrochemical Transformation of Carbon Dioxide. ARC Centre of Excellence for Green Electrochemical Transformation of Carbon Dioxide. This Centre aims to advance carbon dioxide electrochemistry innovations to enable the conversion of carbon dioxide into valuable products and transition Australia to a carbon-neutral economy. This Centre expects to generate new knowledge using experimental and computational approaches to develop systems-level understanding to fu ....ARC Centre of Excellence for Green Electrochemical Transformation of Carbon Dioxide. ARC Centre of Excellence for Green Electrochemical Transformation of Carbon Dioxide. This Centre aims to advance carbon dioxide electrochemistry innovations to enable the conversion of carbon dioxide into valuable products and transition Australia to a carbon-neutral economy. This Centre expects to generate new knowledge using experimental and computational approaches to develop systems-level understanding to furnish industry-ready carbon dioxide utilisation technologies. Expected outcomes include enhanced capacity through collaborations establishing the Centre as an international hub for research, training, technology translation and strategic advice for stakeholders and policymakers. This should accelerate Australia’s progress towards net zero emissions targets and grow a sustainable economy and create future jobs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100236
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Facilities for spectroscopy and diffraction at high pressures. The provision of infrastructure for the study of novel materials under high pressures will enhance Australia's capability in creating new materials and in creating new devices that meet needs in communication, environment and medicine applications. The new facility will enable researchers to understand the response of structures to extreme pressures and will exploit the unique capabilities of the synchrotron light.
Special Research Initiatives - Grant ID: SR180100036
Funder
Australian Research Council
Funding Amount
$650,054.00
Summary
Remediation of PFAS in current and legacy biosolids application sites. This project aims to develop novel immobilisation, adsorption and/or thermal destruction methods for biosolids, soil and groundwater in current and legacy per- and poly-fluroalkyl substance (PFAS) sites receiving biosolids. Biosolids generated during waste water treatment carry an unknown potential risk of soil and groundwater PFAS contamination, through their application in agriculture and rehabilitation sites. This project ....Remediation of PFAS in current and legacy biosolids application sites. This project aims to develop novel immobilisation, adsorption and/or thermal destruction methods for biosolids, soil and groundwater in current and legacy per- and poly-fluroalkyl substance (PFAS) sites receiving biosolids. Biosolids generated during waste water treatment carry an unknown potential risk of soil and groundwater PFAS contamination, through their application in agriculture and rehabilitation sites. This project will provide the first major investigation of the release, fate and remediation of perfluorinated compounds in relation to their environmental pathways through wastewater treatment plants in Australia. The data will be evaluated to determine if perfluorinated compounds should be further incorporated into Australian soil and water quality monitoring programs. The project will provide evidence of research advice and methodologies being successfully adopted by water industry end-users, government regulatory agencies and private remediation industries.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100028
Funder
Australian Research Council
Funding Amount
$4,969,602.00
Summary
ARC Training Centre for Innovative Composites for the Future of Sustainable Mining Equipment. The Centre aims to train industry-focused researchers in advanced manufacturing of new-generation mining equipment and sustainable mining technology, through close collaborations among key universities and mining and manufacturing companies. The Centre will cultivate a team of world-class academic researchers and industry leaders to deliver an innovative program on research of innovative composites coup ....ARC Training Centre for Innovative Composites for the Future of Sustainable Mining Equipment. The Centre aims to train industry-focused researchers in advanced manufacturing of new-generation mining equipment and sustainable mining technology, through close collaborations among key universities and mining and manufacturing companies. The Centre will cultivate a team of world-class academic researchers and industry leaders to deliver an innovative program on research of innovative composites coupled with work-integrated learning, to not only produce a workforce that meets future skills demand but also develop sustainable and cost-effective mining equipment and high-efficiency mining technologies, benefiting the nation's manufacturing and mining sectors and significantly enhancing the competitiveness of the Australian mining industry.Read moreRead less