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This Program Grant brings together a world-leading team of experts to elucidate mechanisms that protect most people from infection by making antibodies, and their failure caused by genes or infections like influenza or HIV. The team will determine mechanisms that protect most people from making antibodies against normal parts of our body, whose failure causes numerous autoimmune diseases including rheumatoid arthritis. The team will develop ways to engineer better antibodies.
Molecular Regulation Of Blood Cell Production And Function
Funder
National Health and Medical Research Council
Funding Amount
$18,330,902.00
Summary
This Program comprises an established team of investigators that have made world-class contributions to the understanding of blood cell formation and function. Research will combine novel multidisciplinary genetic/genomics approaches, expert biochemistry, cell and molecular biological techniques with translational studies in humans to provide new insights into blood cell control and novel avenues for therapies in blood cell diseases such as leukaemia and autoimmune and inflammatory disorders.
Intervening In The Natural History Of Type 1 Diabetes: An Integrated Approach
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
This Program brings together four of Australia’s top type 1 diabetes clinical and lab-based research teams. The program has three intersecting themes. The first theme, pathogenesis, focuses on early life and understanding why type 1 diabetes develops. The second theme, prevention, seeks to identifying new drugs to stop the disease from occurring. The third theme, treatment, aims to improve therapies to replace the cells that are destroyed during the disease process.
Better Outcomes Through Innovations In Clinical Trials: From Personalised Medicine To Population Health
Funder
National Health and Medical Research Council
Funding Amount
$12,215,475.00
Summary
This program aims to develop better health care though advances in clinical trials research and better methods for integrating trial evidence. The team comprises clinician researchers and trialists, biostatisticians, health economists and collaborative networks of clinical investigators. It aims to tackle major health care questions in priority health areas, in cancer, cardiovascular disease, and diabetes, where advances will have substantial impact on reducing death and serious disability.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Discovery And Translation Of Evidence For New Strategies To Combat Cardiovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$17,802,750.00
Summary
The Program brings together clinicians, epidemiologists and statisticians in a unique endeavour combating heart attack and stroke as well as diabetes and kidney disease, all of which are closely related, through “hardening of the arteries”. The Program will provide fresh evidence on innovative strategies for treating and preventing these disorders, as well as strategies for translating them into more effective health policy and improved clinical practice.
ADVANCING THE EVIDENCE BASE FOR CARE AND POLICY IN PRIORITY HEALTH AREAS
Funder
National Health and Medical Research Council
Funding Amount
$11,195,727.00
Summary
This program will improve health care and policy through clinical trials research and better methods for combining trial evidence. The team will tackle priority health areas to reduce death and serious disability: in particular in cancer, cardiovascular disease, diabetes, obesity and neonatal diseases. The program team includes clinicians, epidemiologists, trialists, biostatisticians, and health economists and collaborative networks of clinical investigators in each disease area.
We seek to understand how white blood cells detect and destroy disease, and how molecules of the immune system punch holes in diseased cells. We wish to learn how cancer can sometimes evade the immune system. Our work will also find out how some common treatments for cancer, like chemotherapy, can be used to boost the immune system and eliminate tumours. Through knowledge gained from these studies, we aim to develop new therapies that can help patients with devastating diseases like cancer.