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The Role Of NKT Cell Subsets In The Regulation Of Experimental Autoimmune Encephalomyelitis
Funder
National Health and Medical Research Council
Funding Amount
$142,717.00
Summary
Multiple Sclerosis (MS) is the most common cause of paralysis in young people. EAE is an animal model of MS that recapitulates many features of the human disease. Recent data shows that EAE is mediated by IL-17 producing self-reactive T cells. NKT cells are a group of T cells, whose activation protects against EAE, in an as yet unidentified manner. These studies will provide critical information on the way in which NKT cells regulate immunity and will enhance development of therapies for MS.
The Structural Basis Of T Cell Recognition In The Context Of Lipid Presentation And The CD1 Isoforms
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
CD1 molecules are critical in our host-defence against microbial pathogens. They survey our body for microbial lipids and then present them to our immune system for surveillance by T cell receptors. We aim to understand how a T cell receptor interacts with a CD1-lipid molecule. This interaction is crucial to the activation of our immune response and hence the elimination of the microbe. Once understood, this interaction can potentially be modified and has immunotherapeutic potential.
Follicular Helper T Cell Development And Function: From Mechanisms To Application
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
Antibodies are the basis of most successful vaccinations. Diminished antibody responses lead to immunodeficiency while excessive antibody responses contribute to autoimmune diseases. We are studying a newly identified specialised helper T cell subset, termed follicular helper T cells, which is essential to regulate the high-affinity and long-lived antibody responses. The knowledge should provide new strategies to design better vaccines, to control infections, or to treat autoimmune disorders.
Environmental And Host Contributors To Infectious Health Threats And Burden Of Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$474,712.00
Summary
Infections remain a major cause of morbidity and mortality. I will undertake research in a number of areas, with a focuses on: i)Imported infections: My lead role in and access to a global network of sites that track infections among travellers and immigrants will enable study of emerging priority issues among mobile populations. ii)Waterborne risks: I will perform studies to identify optimal strategies for improving water supply and associated health impacts in developing countries.