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Determinants of Expression, Assembly and Function of the Noradrenaline Transporter. The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepress ....Determinants of Expression, Assembly and Function of the Noradrenaline Transporter. The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepressant drugs and to the design of drugs to prevent the effects of cocaine.Read moreRead less
Age-dependent effects of cannabinoids on emotion, cognition and vulnerablity to addiction. Cannabis is the most widely used illicit drug in Australia so understanding the effects of this drug is of great importance. There is little of no basic research on cannabis currently occurring in Australia. Yet such research is critical in resolving the ambiguities and difficulties inherent in our understanding of the drug. The importance of increasing our understanding of the long-term effects of the dr ....Age-dependent effects of cannabinoids on emotion, cognition and vulnerablity to addiction. Cannabis is the most widely used illicit drug in Australia so understanding the effects of this drug is of great importance. There is little of no basic research on cannabis currently occurring in Australia. Yet such research is critical in resolving the ambiguities and difficulties inherent in our understanding of the drug. The importance of increasing our understanding of the long-term effects of the drug on young developing brains is particularly evident. The information gained in the current project will serve to inform medical and scientific communities, government policy makers, as well as the broader Australian community. Read moreRead less
The central nucleus of the amygdala and alcohol-seeking behaviour. Alcohol abuse and alcoholism is a significant problem in Australia (and throughout the world). However, pharmacological interventions remain limited due to our poor understanding of the neural networks underlying addictive processes. These experiments will explain how the positive rewarding and negative reinforcing aspects of alcohol are transduced within the brain. We believe that our research will facilitate the ability to trea ....The central nucleus of the amygdala and alcohol-seeking behaviour. Alcohol abuse and alcoholism is a significant problem in Australia (and throughout the world). However, pharmacological interventions remain limited due to our poor understanding of the neural networks underlying addictive processes. These experiments will explain how the positive rewarding and negative reinforcing aspects of alcohol are transduced within the brain. We believe that our research will facilitate the ability to treat alcoholism at a pharmacological level, enabling the continuation of abstinence or the prevention of relapse, while allowing other factors such as social support structure and coping skills to be developed for each individual, with flow-on social and economic benefits for society as a whole. Read moreRead less
Roadside saliva based testing for amphetamine-type stimulants in drivers: An evaluation of the relationship between positive drug tests and driving impairment after the consumption of methamphetamine and MDMA. Since the implementation of random saliva tests for illicit substances in Victoria, 1 in 48 drivers intercepted have tested positive to the presence of methamphetamine. Because amphetamines have been reported to increase road crash risk, this finding highlights a significant road traffic p ....Roadside saliva based testing for amphetamine-type stimulants in drivers: An evaluation of the relationship between positive drug tests and driving impairment after the consumption of methamphetamine and MDMA. Since the implementation of random saliva tests for illicit substances in Victoria, 1 in 48 drivers intercepted have tested positive to the presence of methamphetamine. Because amphetamines have been reported to increase road crash risk, this finding highlights a significant road traffic problem. The proposed research will provide information on the most accurate saliva drug test to detect the presence of methamphetamine and MDMA in drivers, and will also provide data on the appropriate amphetamine cut-off level that relates to driving impairment. Accurate drug detection measures will result in better detection of drivers impaired by amphetamines, and in turn deter drivers from driving after consuming amphetamines.
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