New Insights Into The Mechanisms Of Thrombogenesis In Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Atrial fibrillation (AF) is the most common heart rhythm disturbance (arrhythmia), which is associated with a high risk of stroke due to clot formation within the left atria. At present we still only have a limited understanding of the mechanism of clot formation in AF. The aim of this study is to determine the critical mechanisms that contribute to clot formation within the left atria in AF. This knowledge is fundamental to the development of more successful interventional approaches.
Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder. Obstructive sleep apnea (OSA), is four times more common among patients with AF than without. OSA has been associated with a greater recurrence rate of AF after initially successful treatment of AF and treatment of OSA reduces recurrence of AF. To identify the underlying mechanisms, we aim to determine effects of OSA on atrial electrical activation and to characterize sleep apnea in AF patients in a more precise way.