Understanding The Mechanisms Of Atrial Fibrillation: High Density Intra-operative Mapping
Funder
National Health and Medical Research Council
Funding Amount
$94,025.00
Summary
We hypothesize that: During atrial fibrillation, regions acting as short cycle length drivers will demonstrate characteristic sinus rhythm electrophysiology including conduction slowing and abbreviated refractoriness. We aim to correlate the nature of electrical activity in atrial fibrillation with that in sinus rhythm. We will focus on particular anatomic locations that have been shown to be regions of anisotropy and sites where short cycle length rotors have been observed. The anatomic locat ....We hypothesize that: During atrial fibrillation, regions acting as short cycle length drivers will demonstrate characteristic sinus rhythm electrophysiology including conduction slowing and abbreviated refractoriness. We aim to correlate the nature of electrical activity in atrial fibrillation with that in sinus rhythm. We will focus on particular anatomic locations that have been shown to be regions of anisotropy and sites where short cycle length rotors have been observed. The anatomic location and electrophysiologic (EP) characteristics of these regions will vary according to the underlying atrial substrate. We aim to characterise the differences in atrial electrophysiology in AF and sinus rhythm between different pathophysiologic substrates. With high density mapping targeted to critical anatomic sites it will be possible to determine the EP mechanism of short cycle length rotors. We aim to characterise the EP mechanism of these short cycle length regions by analysis of recordings from high density mapping plaques.Read moreRead less
Assessment Of Left Atrial Function Using Electro-anatomic Mapping And Cardiac Magnetic Resonance Imaging
Funder
National Health and Medical Research Council
Funding Amount
$82,554.00
Summary
This study aims to use a novel imaging technique, cardiac magnetic resonance imaging, to assess the structure, function and blood flow of the heart chambers in patients with a heart rhythm abnormality called atrial fibrillation. Atrial fibrillation is the most common heart rhythm abnormality and is a significant cause of stroke in Australia. This study may provide us with better tools to assess the risk of stroke in patients with atrial fibrillation and allow targeted preventive strategies.
Obstructive Sleep Apnoea As A Risk Factor For Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$64,631.00
Summary
Atrial fibrillation is the most common sustained cardiac arrhythmia and obstructive sleep apnoea is a common sleep-related breathing disorder. It has recently been suggested that OSA increases the risk of developing AF . The aim, therefore of this study, is to determine the incidence of sleep apnoea in our population of highly symtomatic patients with atrial fibrillation and to assess the outcome on arrhythmia burden of treatment with continuous positive airways pressure (CPAP).