Asthma Genetics: Dissecting The Missing Heritability And Biology
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
The goal of this application is to apply state-of-the-art technologies to (1) identify genes that increase the risk of developing asthma and (2) help translate this information into knowledge that can be used to improve disease management. I will achieve this by analysing data generated by the Australian Asthma Genetics Consortium and international collaborators.
Ontogeny Of Toll (TLR) Function In Normal And Allergic Children: The Impact Of Microbial-rich Environments
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Reduced exposure to bacteria during early life has become a leading candidate to explain the escalating rate of allergic disease. Despite this, the development and maturation of the pathways involved in normal recognition of bacteria in children has not been explored. In this proposal we set out to address this critical shortcoming in both normal and allergic children. Mapping normal maturation of such pathways will help us to identify better early markers of allergic disease.