Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100140
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
Quarantined ion chromatography mass spectrometry (IC-MS) facility. This proposal seeks to establish a quarantined facility for 'ion chromatography-mass spectrometry', to provide high resolution ion chromatographic and mass spectrometric analytical capability to the environmental, analytical/bioanalyical, and industrial science research communities. The state-of-the-art facility will represent the only quarantined high-resolution IC-MS facility within Australia, and therefore not only support the ....Quarantined ion chromatography mass spectrometry (IC-MS) facility. This proposal seeks to establish a quarantined facility for 'ion chromatography-mass spectrometry', to provide high resolution ion chromatographic and mass spectrometric analytical capability to the environmental, analytical/bioanalyical, and industrial science research communities. The state-of-the-art facility will represent the only quarantined high-resolution IC-MS facility within Australia, and therefore not only support the above communities within Australia, but the potential to facilitate research collaboration internationally, including supporting Australia's leading Antarctic Science programs. Read moreRead less
Understanding and controlling bioavailability: passive dosing of persistent organic pollutants into recombinant cell bioassays. Bioassays with mammalian cell lines may replace animal testing in chemical risk assessment if issues with limited sensitivity can be overcome for very hydrophobic chemicals such as polychlorinated dibenzodioxins. The project will solve this problem by developing a polymer-release dosing technique that assures defined and constant exposure.
Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk. Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot ....Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk. Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot be explained by known chemicals in water samples treated with different disinfectants using a combination of chemical analysis and in-vitro bioassays. Samples with high unexplained effects will then be fractionated to isolate toxicologically relevant disinfection by-products, which will ultimately be identified with non-target chemical analysis.Read moreRead less