New Insights into the Origin and Evolution of Life on Earth. This project aims to provide new insights into the origin of life on Earth, life’s diversification through the Precambrian, and the co-evolution of life and early Earth environments. It will be discipline-leading in that it will take the study of early life to the sub-micrometre and hence sub-cellular level. This will facilitate new opportunities for identifying the types of life present during early Earth history, their metabolisms, c ....New Insights into the Origin and Evolution of Life on Earth. This project aims to provide new insights into the origin of life on Earth, life’s diversification through the Precambrian, and the co-evolution of life and early Earth environments. It will be discipline-leading in that it will take the study of early life to the sub-micrometre and hence sub-cellular level. This will facilitate new opportunities for identifying the types of life present during early Earth history, their metabolisms, cellular chemistry and interactions with their environment. This project aims to also provide new search engines and more robust assessment criteria for life on other planets, and help to resolve specific scientific controversies, for example, the validity of claims for cellular life from 3.5 billion-year-old rocks.Read moreRead less
Artificial Self-Replication of Peptide Nanocapsules. Replication is key to the operation of biology, but how molecular replicators arose spontaneously on early Earth remains an open question. The ability of molecules to self-replicate must have come before the development of the highly evolved enzymes that biology currently employs. The aim of this Future Fellowship is to develop a peptide nanocapsule capable of replicating itself nonenzymatically by self-templated ligation, thus offering a plat ....Artificial Self-Replication of Peptide Nanocapsules. Replication is key to the operation of biology, but how molecular replicators arose spontaneously on early Earth remains an open question. The ability of molecules to self-replicate must have come before the development of the highly evolved enzymes that biology currently employs. The aim of this Future Fellowship is to develop a peptide nanocapsule capable of replicating itself nonenzymatically by self-templated ligation, thus offering a platform that possesses the traits needed for Darwinian evolution to emerge. By obtaining a better understanding of the design and function of self-replicating systems, this project is expected to transform our understanding of some of the key chemical principles needed for life's emergence.Read moreRead less