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Synthetic, Molecular and Biological Studies on Novel Marine Metabolites Isolated from Great Barrier Reef Sponges. Whilst structurally remarkable marine natural products, generated via unprecedented biosynthetic pathways, continue to be isolated from organisms found on the Barrier Reef these substances remain largely unexploited in terms of both their potent biological and ecological properties. Efficient syntheses of two classes of marine metabolites will be undertaken to allow biological, biosy ....Synthetic, Molecular and Biological Studies on Novel Marine Metabolites Isolated from Great Barrier Reef Sponges. Whilst structurally remarkable marine natural products, generated via unprecedented biosynthetic pathways, continue to be isolated from organisms found on the Barrier Reef these substances remain largely unexploited in terms of both their potent biological and ecological properties. Efficient syntheses of two classes of marine metabolites will be undertaken to allow biological, biosynthetic and ecological evaluation of advanced intermediates and final products. Such evaluations will provide new insights into the therapeutic and ecological potential as well as the origins of these natural products. New agents for the management of marine ecosystems and the treatment of oncological and other diseases should emerge.Read moreRead less
Total Synthesis and Biological Evaluation of Australian Sponge Metabolites. The development of functional syntheses of Australian natural products and certain analogues of ecological and therapeutic significance will emerge. Such activities will lead to the identification and evaluation of molecular entities of value in managing marine environments, reduce the need for removal of organisms from marine environments both within and outside of Australia as well as helping maintain and enhance chemi ....Total Synthesis and Biological Evaluation of Australian Sponge Metabolites. The development of functional syntheses of Australian natural products and certain analogues of ecological and therapeutic significance will emerge. Such activities will lead to the identification and evaluation of molecular entities of value in managing marine environments, reduce the need for removal of organisms from marine environments both within and outside of Australia as well as helping maintain and enhance chemical synthesis capacity within the country. The proposed studies could lead to the identification of related natural products produced by organisms on the Great Barrier Reef and that may display even more potent activities and/or complementary ecological roles.Read moreRead less
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understand ....Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understanding of OMCG criminal activity across Australia and refined theory development about co-offending in criminal groups. The project will lead to improved policy, legislation and policing practice to prevent OMCG crime and dismantle OMCG criminal networks in more cost-effective ways.Read moreRead less
Neurons and neurotransmitters that control the apnoeic response to irritation of the larynx. Normal function of the larynx enables breathing, cough, singing, speech and many other normal functions. This project will reveal how nerves in the brain coordinate to achieve these many functions; in particular the way that breathing stops if fluid or smoke enters the larynx.
Domestic violence disclosure schemes: A national review. In 2014 family violence was declared a national emergency in Australia. In the years since there has been extensive law reform activity. Domestic violence disclosure schemes have emerged within this context as a policy option that may improve safety outcomes for victims. However, there is currently no evidence as to the impact of these schemes and no consultation with victims as to their value. This project aims to generate the evidence re ....Domestic violence disclosure schemes: A national review. In 2014 family violence was declared a national emergency in Australia. In the years since there has been extensive law reform activity. Domestic violence disclosure schemes have emerged within this context as a policy option that may improve safety outcomes for victims. However, there is currently no evidence as to the impact of these schemes and no consultation with victims as to their value. This project aims to generate the evidence required to inform decisions about the introduction of these schemes, to better understand what victim/survivors want from them, and how such schemes can be effectively operationalised. The findings seek to be relevant to all Australian states and territories as well as international jurisdictions.Read moreRead less
Preventing intimate partner homicide. The project aims to develop a framework for an integrated whole systems preventive approach to intimate partner homicide – the most common type of violence against women worldwide and the leading cause of death amongst Australian women aged between 15 and 44. The project will review a decade of intimate partner homicides in Australia to identify points of intervention that might have prevented killings. This knowledge is intended to inform and help develop a ....Preventing intimate partner homicide. The project aims to develop a framework for an integrated whole systems preventive approach to intimate partner homicide – the most common type of violence against women worldwide and the leading cause of death amongst Australian women aged between 15 and 44. The project will review a decade of intimate partner homicides in Australia to identify points of intervention that might have prevented killings. This knowledge is intended to inform and help develop a more risk-sensitive preventive approach to intimate partner homicides in Australia and overseas, enhancing women’s security and preventing their deaths.Read moreRead less
Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop ....Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop evidence-based insights into how it can be mitigated. The research should produce benefits for Australia by providing policymakers with a risk-assessment tool to identify individuals most 'at-risk' of violent extremism, and by providing knowledge about the services families may require to de-radicalise loved ones.Read moreRead less
Understanding and preventing gun violence: A qualitative study. Gun violence causes significant harm across Australian communities. Excluding sexual assault, firearms feature in nearly one in 10 violent crimes. The annual costs of gun violence run into tens of millions of dollars. This project aims to make an original qualitative contribution to understanding and preventing gun violence in three contexts: drug dealing/trafficking, other organised crime activity, and armed robbery. The proposed r ....Understanding and preventing gun violence: A qualitative study. Gun violence causes significant harm across Australian communities. Excluding sexual assault, firearms feature in nearly one in 10 violent crimes. The annual costs of gun violence run into tens of millions of dollars. This project aims to make an original qualitative contribution to understanding and preventing gun violence in three contexts: drug dealing/trafficking, other organised crime activity, and armed robbery. The proposed research would be the first study nationally - and one of the very few internationally - to interview convicted gun crime users about the acquisition and use of firearms in criminal life. Project results are expected to have direct implications for reducing the impact of gun violence in Australia.Read moreRead less
Lifting the burden of imprisonment: Creating safer and stronger communities. This project aims to identify how a reduction in imprisonment rates could benefit Australian communities and enhance their safety and wellbeing. It will link a range of statistical data sources on imprisonment, crime and community wellbeing. We will, for the first time, comprehensively demonstrate the impact of imprisonment on individuals and communities in Australia and beyond. Expected outcomes of this project include ....Lifting the burden of imprisonment: Creating safer and stronger communities. This project aims to identify how a reduction in imprisonment rates could benefit Australian communities and enhance their safety and wellbeing. It will link a range of statistical data sources on imprisonment, crime and community wellbeing. We will, for the first time, comprehensively demonstrate the impact of imprisonment on individuals and communities in Australia and beyond. Expected outcomes of this project include expansion and innovation of coercive mobility theory, novel integration of data, and a forecasting tool to assess the impact of imprisonment reduction on communities. This evidence will assist advocacy groups and policy makers seeking to address Australia’s burgeoning imprisonment rate.Read moreRead less