Media Formulations To Enhance Embryo Formation In Assisted Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$660,133.00
Summary
The increasing age of parenthood has led to an explosion in the demand for assisted reproductive technologies such as in vitro fertilisation (IVF). This procedure has a poor success rate and is limited by the ability of fertilised eggs to mature into early embryos in the lab prior to being transferred into women. We will develop new compounds that improve embryo growth in the clinic, which will improve IVF success rates.
Nicotinamide Adenine Dinucleotide (NAD+)-raising Agents For Improving Oocyte Quality
Funder
National Health and Medical Research Council
Funding Amount
$445,827.00
Summary
Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.
Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.
Discovery Early Career Researcher Award - Grant ID: DE120100796
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Androgens and ovarian function. This innovative project aims to identify the role androgens play in the complex processes required for successful ovarian follicle development and ovulation. The project aims to identify androgen regulated pathways that orchestrate follicle development, which will have significance in the control of fertility and the advancement of reproductive technologies.
Life-saving chemo/radio-therapy commonly renders women and girls who survivor cancer infertile or sterile. We have discovered a new means of preserving the fertility of female mice exposed to chemo/radio therapy. In this project we will apply these advances to human ovarian tissue/eggs for the first time. We have access to these rare tissues for research purposes. This project will develop new approaches to fertility preservation for cancer survivors.
Targeted Disruption Of Lipoxygenase Enzymes To Prevent Oxidative Stress-mediated Pathologies In The Male Germline
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
An estimated 80 million individuals suffer from infertility globally with at least 50% of these cases due to defects in sperm function. Unfortunately, due to a severe lack of knowledge surrounding sperm biology and dysfunction, no successful curative or preventative measures have been established. My project will study why sperm cells die and investigate new ways to limit cellular stress so we can develop new therapeutic strategies to mitigate the growing problems in male reproductive health.
Efficient Signal Transmission Techniques for Future Wireless Communications Systems. The project aims at developing efficient signal transmission techniques that enable advanced telecommunication services to achieve high quality and cover greater geographic areas with low cost and minimal infrastructure. The outcomes of the project will enable high performance, high data rate and cost-effective wireless communications in Australia. The outcomes can be directly applied to current and future wirel ....Efficient Signal Transmission Techniques for Future Wireless Communications Systems. The project aims at developing efficient signal transmission techniques that enable advanced telecommunication services to achieve high quality and cover greater geographic areas with low cost and minimal infrastructure. The outcomes of the project will enable high performance, high data rate and cost-effective wireless communications in Australia. The outcomes can be directly applied to current and future wireless LAN, cellular mobile networks, WiMax systems, WiFi and other wireless networks. In addition, it will support and enhance the social and economic benefit of wireless access to broadband networks in rural and regional Australia.Read moreRead less
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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A Population-based Record Linkage Study Of The Impact Of Chlamydia Infection On Reproductive Health In Women
Funder
National Health and Medical Research Council
Funding Amount
$405,114.00
Summary
Chlamydia is the most commonly notified infection in young Australian women and reports of cases are increasing. While chlamydia is thought to result in infertility and ectopic pregnancy in later life, the evidence for this is limited. This will be the largest, most comprehensive study in the world to determine the risk of infertility and ectopic pregnancy following chlamydia infection. The results will provide vital information to more cost-effectively plan strategies to control chlamydia in Au ....Chlamydia is the most commonly notified infection in young Australian women and reports of cases are increasing. While chlamydia is thought to result in infertility and ectopic pregnancy in later life, the evidence for this is limited. This will be the largest, most comprehensive study in the world to determine the risk of infertility and ectopic pregnancy following chlamydia infection. The results will provide vital information to more cost-effectively plan strategies to control chlamydia in Australia.Read moreRead less
Processing and Compression of Digital Video in Immersive Environments. This project will have significant economic and social benefits, both in terms of the technologies developed and the new applications in training and entertainment supported by them. This project supports the national research priority "Frontier Technologies for Building and Transforming Australian Industries", supporting media and creative industries and assisting organisations to collaborate across large distances. These be ....Processing and Compression of Digital Video in Immersive Environments. This project will have significant economic and social benefits, both in terms of the technologies developed and the new applications in training and entertainment supported by them. This project supports the national research priority "Frontier Technologies for Building and Transforming Australian Industries", supporting media and creative industries and assisting organisations to collaborate across large distances. These benefits will be realised in both urban and remote areas. The collaboration between the CIs and the iCinema Centre will lead to the application of advanced technology to real-world problems.Read moreRead less