Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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Eco-NextNet: An Ecologically-Inspired Adaptive Network Resource Management Framework for a Sustainable Next Generation Mobile Network for Ubiquitous Services. Ubiquitous communications service is the most important element of today's societies. In urban and rural areas of the country as well as at the time of natural disasters such as bushfires, floods, cyclones, it is vital to devise alternative schemes to create and sustain on-demand telecommunications services. In most cases it is not the lac ....Eco-NextNet: An Ecologically-Inspired Adaptive Network Resource Management Framework for a Sustainable Next Generation Mobile Network for Ubiquitous Services. Ubiquitous communications service is the most important element of today's societies. In urban and rural areas of the country as well as at the time of natural disasters such as bushfires, floods, cyclones, it is vital to devise alternative schemes to create and sustain on-demand telecommunications services. In most cases it is not the lack of technology that hinders the implementation of a reliable communications service, but it is the resource allocation. In this project we propose a novel sustainable resource management framework inspired by natural ecological systems to solve the above problem. Upon completion, Australia will be in forefront of technologies related to the management of complex networks.Read moreRead less
Role Of The Anaphase-Promoting Complex Activator Cdh1 In Oocyte Maturation And Meiotic Aneuploidy
Funder
National Health and Medical Research Council
Funding Amount
$526,878.00
Summary
Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.
Industrial Transformation Training Centres - Grant ID: IC140100003
Funder
Australian Research Council
Funding Amount
$2,389,935.00
Summary
The ARC Research Training Centre for Naval Design and Manufacturing. ARC Training Centre for Transforming Australia's Naval Manufacturing Industry. The aim of the Training Centre is to transform the Australian naval manufacturing industry by creating a new cohort of industry-focused, high-level and broadly skilled engineers and researchers. The resulting network of engineering researchers will enable the industry to more rapidly innovate and solve key problems concerning the efficient design, co ....The ARC Research Training Centre for Naval Design and Manufacturing. ARC Training Centre for Transforming Australia's Naval Manufacturing Industry. The aim of the Training Centre is to transform the Australian naval manufacturing industry by creating a new cohort of industry-focused, high-level and broadly skilled engineers and researchers. The resulting network of engineering researchers will enable the industry to more rapidly innovate and solve key problems concerning the efficient design, construction and sustainment of naval platforms. This industrial transformation will bring significant benefits to Australia as it commences a very ambitious shipbuilding program comprising the design and manufacture of new fleets of submarines, future frigates and patrol boats. The success of these major projects is reliant on developing this cohort of researchers to solve the key research questions.Read moreRead less
Reconciliation strategies for continuous variable quantum key distribution. This project aims to advance a novel key distribution method, called quantum key distribution, which distributes secure keys using the quantum state of optical channels. Key distribution is a foundational part of data security, allowing digital keys to be securely exchanged between two or more parties, before they are used to protect and share information. The expected outcome is new rateless error correction codes desi ....Reconciliation strategies for continuous variable quantum key distribution. This project aims to advance a novel key distribution method, called quantum key distribution, which distributes secure keys using the quantum state of optical channels. Key distribution is a foundational part of data security, allowing digital keys to be securely exchanged between two or more parties, before they are used to protect and share information. The expected outcome is new rateless error correction codes designed specifically to implement quantum key distribution over long distances. Quantum key distribution is beneficial for ultra-secure communications as it avoids the vulnerability to weak random numbers and quantum-computing brute force attacks that currently threated the security of data protected by existing methods. Read moreRead less
Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100009
Funder
Australian Research Council
Funding Amount
$3,317,500.00
Summary
ARC Research Hub for Microrecycling of battery and consumer wastes . This project aims to transform Australia’s waste and resource recovery industry by equipping it with scientifically developed advanced manufacturing capability, focusing on small-scale processing of materials produced from battery and consumer wastes which would otherwise mostly end up in landfill. The project will deliver new knowledge in high-temperature reactions of waste and selective synthesis techniques to transform waste ....ARC Research Hub for Microrecycling of battery and consumer wastes . This project aims to transform Australia’s waste and resource recovery industry by equipping it with scientifically developed advanced manufacturing capability, focusing on small-scale processing of materials produced from battery and consumer wastes which would otherwise mostly end up in landfill. The project will deliver new knowledge in high-temperature reactions of waste and selective synthesis techniques to transform waste into valuable materials and products, including metallic alloys, oxides and carbon. Expected outcomes include industry adoption of commercially viable technology and processes where low value or complex waste is reformed into higher value materials, creating jobs and significant environmental and social benefits.Read moreRead less
Synthesis of Activated Carbon Supported Zero Valent Iron Nanoparticles and Application to Contaminant Degradation in Benthic Sediments. Sediment contamination is a major problem in harbours and estuaries around Australia. For example, in Sydney Harbour, a total fishing ban has been implemented as a result of excessive levels of dioxins and benzofurans in fish tissues. There is also concern at the possibility of large scale contamination of Botany Bay as a result of historic industrial activity a ....Synthesis of Activated Carbon Supported Zero Valent Iron Nanoparticles and Application to Contaminant Degradation in Benthic Sediments. Sediment contamination is a major problem in harbours and estuaries around Australia. For example, in Sydney Harbour, a total fishing ban has been implemented as a result of excessive levels of dioxins and benzofurans in fish tissues. There is also concern at the possibility of large scale contamination of Botany Bay as a result of historic industrial activity around the Bay. While dredging and on-land treatment of sediments is being adopted at the most severely contaminated sites, the cost of this approach is exorbitant. For sites where removal of contaminated sediments cannot be justified, the approach proposed in this study of a technology that entraps contaminants and enhances their in situ biodegradation is potentially a way forward.Read moreRead less
Meta-composites of high level thermal dimensional stability. This project aims to design and manufacture meta-composites of high level thermal dimensional stability for future space-based imagery applications. The project will develop the fundamentals of novel enabling technologies including: meta-composite material design, miniature fibre tow placement, optimal processing window and the high precision net-shape additive manufacturing of continuous fibre laminated composites without needs of fol ....Meta-composites of high level thermal dimensional stability. This project aims to design and manufacture meta-composites of high level thermal dimensional stability for future space-based imagery applications. The project will develop the fundamentals of novel enabling technologies including: meta-composite material design, miniature fibre tow placement, optimal processing window and the high precision net-shape additive manufacturing of continuous fibre laminated composites without needs of follow-up machining. This is expected to eliminate or minimise the current need to use a motorised adjustment system for space-based imagery applications. This project will develop the know-how for design and technology to manufacture meta-composites of high level thermal dimensional stability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561173
Funder
Australian Research Council
Funding Amount
$207,189.00
Summary
High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomics Workstation. As research in the biological sciences moves into post-genomics era, so attention has focused on the development of technologies capable of characterizing the molecular complexity inherent in the proteome. Recent technical innovations in this field have resulted in the advancement of mass spectrometers that are capable of exemplifying unknown proteins with great efficiency. These new technologies are ....High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomics Workstation. As research in the biological sciences moves into post-genomics era, so attention has focused on the development of technologies capable of characterizing the molecular complexity inherent in the proteome. Recent technical innovations in this field have resulted in the advancement of mass spectrometers that are capable of exemplifying unknown proteins with great efficiency. These new technologies are central to any institution committed to the development of a competitive research nexus in biological sciences. The purpose of this application is to upgrade the mass spectrometry facility at the University of Newcastle such that it is able to provide cutting edge support to the extensive scientific community within the Hunter region.Read moreRead less