Selective Isolation And In Vivo Properties Of Dopamine Neurons Generated From Embryonic Stem Cells.
Funder
National Health and Medical Research Council
Funding Amount
$505,389.00
Summary
This research aims to develop a procedure that allows for the safe and effective use of stem cells as a therapy for Parkinson’s disease. It is based on the concept that new dopamine neurons, generated from stem cells, can be implanted into the brain of the patients in order to replace those lost to the disease, thereby improving motor function.
Precipitation in shallow convection over the Southern Ocean. This project aims to quantify the amount of precipitation over the Southern Ocean and identify the key dynamical and microphysical processes that lead to its development. Large uncertainties exist in the frequency and intensity of precipitation, which limits the ability to model the coupled Southern Ocean climate system. Observations from the RV Investigator, an Australian marine research vessel, have revealed heavy precipitation event ....Precipitation in shallow convection over the Southern Ocean. This project aims to quantify the amount of precipitation over the Southern Ocean and identify the key dynamical and microphysical processes that lead to its development. Large uncertainties exist in the frequency and intensity of precipitation, which limits the ability to model the coupled Southern Ocean climate system. Observations from the RV Investigator, an Australian marine research vessel, have revealed heavy precipitation events within the shallow convection commonly found between fronts that have not been captured by either satellite observations or numerical models. This project will improve weather forecasts, including precipitation, and climate projections over the Southern Ocean and the adjoining Antarctic and the southern part of Australia.Read moreRead less
National Centre Of Research Excellence To Improve Management Of Peripheral Arterial Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,618,637.00
Summary
Approximately 15% of adults have blockages or weakness of major arteries in the periphery, associated with impaired quality of life and a high mortality. Significant management deficiencies for these problems include limited diagnostic, prognostic and treatment options, as well as poor adoption of evidence based practice. The proposed national centre will bring together a group of experts in the field to instigate a number of initiatives to improve patient management.
Innovative Technology for At-Scene Forensic Analysis using Microfluidics and Chemiluminescence. The major outcome of this project will be innovative reagents and strategies optimised for the detection of priority analytes such as drugs, explosives and chemical warfare agents. These will utilise a new technology platform based upon laboratory on a chip/microfluidics to enable the development of analytical methodologies suitable for use at crime scenes.This programme of research falls within a Nat ....Innovative Technology for At-Scene Forensic Analysis using Microfluidics and Chemiluminescence. The major outcome of this project will be innovative reagents and strategies optimised for the detection of priority analytes such as drugs, explosives and chemical warfare agents. These will utilise a new technology platform based upon laboratory on a chip/microfluidics to enable the development of analytical methodologies suitable for use at crime scenes.This programme of research falls within a National Research Priority namely 'Protecting Australia from terrorism and crime'. Through our current forensic science research collaboration the outcomes will build significantly on Australia's existing strengths in rapid detection using new analytical technologies.Read moreRead less
Towards highly-efficient hydrogen gas turbines. The increasing interest in green hydrogen has led to a need for research and development in combustion systems that can accommodate hydrogen. One promising technology is low-emission gas turbines, which is a key player in the electricity market. However, hydrogen gas turbines are susceptible to a phenomenon called thermoacoustic instability, causing loud noise and can damage equipment. This project represents the first comprehensive study of the ef ....Towards highly-efficient hydrogen gas turbines. The increasing interest in green hydrogen has led to a need for research and development in combustion systems that can accommodate hydrogen. One promising technology is low-emission gas turbines, which is a key player in the electricity market. However, hydrogen gas turbines are susceptible to a phenomenon called thermoacoustic instability, causing loud noise and can damage equipment. This project represents the first comprehensive study of the effects of hydrogen fuel on thermoacoustic instability under conditions relevant to gas turbines. By examining low-order models, commonly used for designing gas turbines, this project can significantly advance the field and facilitate the adoption of green hydrogen as a fuel source.Read moreRead less
The dynamics of subtropical anticyclones and the connection to drought, heatwaves and bushfires in southern Australia. The aim of the project is to understand the dynamics of anticyclones (high pressure systems) in the region of southern Australia. The study of anticyclones in the region is important because of their very strong connection to rainfall in the winter, and heatwaves and bushfires in the summer, and because so little work has been done on understanding what is the defining feature o ....The dynamics of subtropical anticyclones and the connection to drought, heatwaves and bushfires in southern Australia. The aim of the project is to understand the dynamics of anticyclones (high pressure systems) in the region of southern Australia. The study of anticyclones in the region is important because of their very strong connection to rainfall in the winter, and heatwaves and bushfires in the summer, and because so little work has been done on understanding what is the defining feature of the climate of southern Australia. Understanding what controls the location and strength of these features will go a long way to explaining how the climate of southern Australia will change in a warmer world.Read moreRead less
Suppression Of NADPH Oxidase-derived Oxidative Stress By Anti-sense Probes And HDL In Human Vascular Endothelium
Funder
National Health and Medical Research Council
Funding Amount
$455,250.00
Summary
In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) develo ....In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) developed in our laboratory, which block a particular gene causing oxidative stress, we will determine whether this gene is responsible for the formation of oxyradicals in human and mouse cells grown in culture. In addition, we will explore whether this gene is turned on by factors known to be involved in CHD. Finally, we will also investigate whether the good cholesterol known as HDL can act to prevent oxidative stress in human cells, as we discovered it appears to do in living arteries in vivo. If we find it has the same protective effect in endothelium, we will determine how it does this, and which component proteins of the HDL particle are important. This might suggest new treatments to prevent acute events leading to heart attack and stroke, and possibly new applications where damage appears to result from acute oxidative stress, such as in the brain soon after a stroke has occurred. We also have a plan to develop antisense drugs that will target the important gene specifically in the affected endothelium. In addition, we have other specific new drugs that will block this system in arteries. Simultaneously we will be testing the role of this gene in mouse and rabbit models of artery disease, for both our types of drugs might provide valuable new therapeutic agents to target the underlying cause of CHD and not just its symptoms as current drugs do.Read moreRead less
The impact of India-Asia tectonics on climate. This interdisciplinary project aims to determine the controls of tectonics on global climate in the last 50 million years. A combination of tectonics, paleogeography, climate modelling and high-performance computing will be applied to test systematically outstanding issues in the reconstruction of the Indo-Asia region and their landmass/seaways configurations and topography, which have bedevilled previous models of paleoclimate evolution. The propos ....The impact of India-Asia tectonics on climate. This interdisciplinary project aims to determine the controls of tectonics on global climate in the last 50 million years. A combination of tectonics, paleogeography, climate modelling and high-performance computing will be applied to test systematically outstanding issues in the reconstruction of the Indo-Asia region and their landmass/seaways configurations and topography, which have bedevilled previous models of paleoclimate evolution. The proposal expects to generate novel knowledge in the area at the boundary between tectonics, paleoclimate modelling and present-day climate. This provides significant benefits to the interpretation of tectonics–climate coupling as current drivers of climate evolution.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100866
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
Intense thunderstorms in the tropics and subtropics under global warming. This project aims to determine how the frequency of intense tropical and subtropical thunderstorms will change as a result of future global warming. Climate models project that the energy available to such storms will increase in the future, but the reasons for this increase in available energy, and the implications for thunderstorm activity, remain uncertain. Using observations and high-resolution models, the project expe ....Intense thunderstorms in the tropics and subtropics under global warming. This project aims to determine how the frequency of intense tropical and subtropical thunderstorms will change as a result of future global warming. Climate models project that the energy available to such storms will increase in the future, but the reasons for this increase in available energy, and the implications for thunderstorm activity, remain uncertain. Using observations and high-resolution models, the project expects to generate new knowledge of the mechanisms driving changes in intense thunderstorm activity under climate change, and to provide more accurate projections of the frequency of intense thunderstorms in a warmer climate. This project should deliver benefits to sectors of the economy such as agriculture and transportation, which are significantly exposed to such hazards.Read moreRead less