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A paradigm of genomic discovery - an investigation of the allelic architecture of height. Understanding the complexities of the human body from its DNA sequence has proven difficult. Genomic discovery is best developed using stable, easily measurable and highly heritable characteristics such as height. By taking advantage of 2 large population surveys of adult and adolescent stature we shall apply modern molecular techniques and statistical strategies to identify and characterise the exact chang ....A paradigm of genomic discovery - an investigation of the allelic architecture of height. Understanding the complexities of the human body from its DNA sequence has proven difficult. Genomic discovery is best developed using stable, easily measurable and highly heritable characteristics such as height. By taking advantage of 2 large population surveys of adult and adolescent stature we shall apply modern molecular techniques and statistical strategies to identify and characterise the exact changes in DNA that determine height. This work builds on substantial preliminary leads from unique resources and complementary expertise in the scientific specialties. The results from this work will inform other genomic research and provide information about growth and bone biology.Read moreRead less
Mutagenesis and combinatorial algorithms for sequencing problematic genomic regions. This project will develop a remarkable and original approach to DNA sequencing with potential to radically improve the speed, accuracy and effectiveness of existing sequencing technologies. It is especially useful for dealing with difficult-to-sequence genomic regions and has implications for all sequencing projects, including completion of the Human Genome Project. The approach involves generating, and wholly o ....Mutagenesis and combinatorial algorithms for sequencing problematic genomic regions. This project will develop a remarkable and original approach to DNA sequencing with potential to radically improve the speed, accuracy and effectiveness of existing sequencing technologies. It is especially useful for dealing with difficult-to-sequence genomic regions and has implications for all sequencing projects, including completion of the Human Genome Project. The approach involves generating, and wholly or partially sequencing, mutated copies of problematic regions of the target genome. Advanced combinatorial algorithms are then used to form highly probable alignments between strings and determine the unknown sequence. The approach has additional benefits in detecting single-nucleotide polymorphisms and sequencing errors.Read moreRead less
An integrated molecular approach to human evolution. This project aims to use the power of High Throughput Sequencing to investigate a range of genetic mechanisms that facilitate rapid human adaptation to diverse environments. This project expects to create the first ultra-high-quality Aboriginal Australian reference genome using Single Molecule, Real-Time Sequencing, which will expand the known range of human genomic and non-genomic variation. The results should offer the first detailed, long- ....An integrated molecular approach to human evolution. This project aims to use the power of High Throughput Sequencing to investigate a range of genetic mechanisms that facilitate rapid human adaptation to diverse environments. This project expects to create the first ultra-high-quality Aboriginal Australian reference genome using Single Molecule, Real-Time Sequencing, which will expand the known range of human genomic and non-genomic variation. The results should offer the first detailed, long-term reconstruction of the evolutionary history of human adaptability to specific environmental and cultural stressors. Importantly, the translation of the results to biomedical research will shed new light on the origins of modern diseases.Read moreRead less
Using genetics to recover Australia's lost history. This project aims to use historic hair samples collected by anthropological expeditions in the early 20th Century to generate the first genetic map of Aboriginal Australia – in order to reconstruct Australia’s pre-European genetic and cultural past. The map and the detailed contextual and genealogical information from museum archives will assist Aboriginal communities and individuals to reconstruct their personal and family history and trace an ....Using genetics to recover Australia's lost history. This project aims to use historic hair samples collected by anthropological expeditions in the early 20th Century to generate the first genetic map of Aboriginal Australia – in order to reconstruct Australia’s pre-European genetic and cultural past. The map and the detailed contextual and genealogical information from museum archives will assist Aboriginal communities and individuals to reconstruct their personal and family history and trace ancestry and augment oral or written records. The combination of cutting-edge science, detailed archival research, and a comprehensive family outreach and reporting program will be a step change in assisting Australia’s reconciliation process, the Stolen Generation, and repatriation of Indigenous remains.Read moreRead less
Developing DNA tracking methods to identify illegally logged timber products from Africa. Illegal logging causes societal and environmental forest degradation, and is a high priority for international control. This project will produce a range of DNA methods that allow the tracing of the geographic source of origin for timber products from African tropical forests that will allow producers and consumers to better market and choose their products.
Evolution, disease and extinction - using ancient and modern Deoxyribonucleic acid (DNA) to investigate molecular evolution in the Tasmanian devil. The Tasmanian devil is Australia's largest living marsupial carnivore and one of Tasmania's key tourism icons. Extinction in the wild will have long-term impacts on Tasmanian native ecosystems and economy. This study will provide critical genetic data and tools to monitor and prioritise conservation strategies, including insurance populations and dis ....Evolution, disease and extinction - using ancient and modern Deoxyribonucleic acid (DNA) to investigate molecular evolution in the Tasmanian devil. The Tasmanian devil is Australia's largest living marsupial carnivore and one of Tasmania's key tourism icons. Extinction in the wild will have long-term impacts on Tasmanian native ecosystems and economy. This study will provide critical genetic data and tools to monitor and prioritise conservation strategies, including insurance populations and disease suppression, aimed at preventing extinction. It will strengthen ongoing conservation programs carried out by the Save the Tasmanian Devil Program and will help publicise the plight of the devil both nationally and internationally.Read moreRead less
The roles of relatedness and reproductive success in complex social systems of dolphins. Theories of the role of genetic relatedness and reproductive success in mammalian social behaviour have mostly been restricted to primates and carnivores. Coexisting alternative strategies within one population of bottlenose dolphins (Shark Bay WA) offer unprecedented opportunities for such investigations. The male alliances? complexity is unparalleled outside humans, and may require new theory. Some femal ....The roles of relatedness and reproductive success in complex social systems of dolphins. Theories of the role of genetic relatedness and reproductive success in mammalian social behaviour have mostly been restricted to primates and carnivores. Coexisting alternative strategies within one population of bottlenose dolphins (Shark Bay WA) offer unprecedented opportunities for such investigations. The male alliances? complexity is unparalleled outside humans, and may require new theory. Some female lineages show tool-use - rare outside humans, and virtually unknown in marine species. Our behavioural and genetic database has exceptional size, detail and duration for marine mammals, and is most valuable if continued while known individuals' offspring reach a stage where they can be sampled.Read moreRead less
Understanding how cells compact and segregate DNA in vertebrates. How a cell compacts and divides its DNA is still a major unanswered question in biology. This project will determine the way in which a cell compacts its DNA nearly ten thousand fold to allow the faithful and accurate segregation to daughter nuclei.
Discovery Early Career Researcher Award - Grant ID: DE170100443
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Landscape genomics to make an endangered community resilient. This project aims to use landscape genomic techniques to assess how key species of the critically endangered Box-Gum Grassy Woodland community migrate and adapt under changing environmental conditions. Changing climate and land use threaten ecological communities, and alter environments at alarming rates. When species are pushed beyond their environmental tolerances, they will migrate, adapt or face local extinction. This alteration o ....Landscape genomics to make an endangered community resilient. This project aims to use landscape genomic techniques to assess how key species of the critically endangered Box-Gum Grassy Woodland community migrate and adapt under changing environmental conditions. Changing climate and land use threaten ecological communities, and alter environments at alarming rates. When species are pushed beyond their environmental tolerances, they will migrate, adapt or face local extinction. This alteration of the community structure affects the stability and function of the ecosystem. Expected outcomes include efficient use of limited conservation resources, ensuring the long term persistence of the endangered community.Read moreRead less
Fire, bees and other disturbances: the basis for variation in genetic diversity in long-lived plants. An understanding of processes generating temporal and spatial patterns of genetic diversity in perennial plants must underpin successful conservation. Our long-term study will exploit systems in the family Proteaceae in which we have completed foundation studies. We will develop and extend molecular techniques to measure (i) genetic changes from seed to adult, (ii) gene flow by different pollina ....Fire, bees and other disturbances: the basis for variation in genetic diversity in long-lived plants. An understanding of processes generating temporal and spatial patterns of genetic diversity in perennial plants must underpin successful conservation. Our long-term study will exploit systems in the family Proteaceae in which we have completed foundation studies. We will develop and extend molecular techniques to measure (i) genetic changes from seed to adult, (ii) gene flow by different pollinator classes, and (iii) genetic contamination by foreign gene pools, in systems affected by introduced pollinators and natural and cultivar hybridization. Most importantly, we will use fire as an accelerant of generational change and test fitness consequences of changes in genotypic diversity.Read moreRead less