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Multiscale modelling: Applications to the Biomedical Sciences. 1) Significant reductions in the costs of developing pharmaceutical treatments, 2) Substantial reduction in hospitalisation costs, 3) Improved treatment of wounds, a significant cause of chronic ill-health which presently costs the Australian HealthCare System A$500,000,000/year.
Optimism, Pessimism and Confidence - Their economic impacts. When modelling uncertainty, economists typically assume people utilise well-behaved and precise probabilities. As most people have only the vaguest conception of chances of terrorist acts, of contracting SARS, or of extreme market volatility, this limits usefulness of the standard model in predicting or guiding choice. This project aims to incorporate a richer set of attitudes about uncertainty into economic theory, including impreci ....Optimism, Pessimism and Confidence - Their economic impacts. When modelling uncertainty, economists typically assume people utilise well-behaved and precise probabilities. As most people have only the vaguest conception of chances of terrorist acts, of contracting SARS, or of extreme market volatility, this limits usefulness of the standard model in predicting or guiding choice. This project aims to incorporate a richer set of attitudes about uncertainty into economic theory, including imprecise estimates of chance, optimistic (or pessimistic) bias, and relative confidence. This will enable more rigorous analysis of topics like irrational exuberance (panic), consumer stampedes, and (in)tolerance of risk, thereby improving the measurement of benefits and costs of related actions or policies.Read moreRead less
Adaptive and Integrated Resource Allocation. By leveraging progress in communication technologies, adaptive and integrated optimization systems will open innovative application areas critical to Australia, yet outside the scope of existing optimization technology. For instance, they will dispatch and reallocate ambulances in real time, help contain pandemics, allocate resources dynamically to extinguish bushfires, and assist in failure recovery of energy infrastrutures. These systems will also s ....Adaptive and Integrated Resource Allocation. By leveraging progress in communication technologies, adaptive and integrated optimization systems will open innovative application areas critical to Australia, yet outside the scope of existing optimization technology. For instance, they will dispatch and reallocate ambulances in real time, help contain pandemics, allocate resources dynamically to extinguish bushfires, and assist in failure recovery of energy infrastrutures. These systems will also solve existing logistics and manufacturing applications better, making these industries more effective and reactive. The project also aims at establishing a center of excellence in optimization in Melbourne with an international reputation in research, teaching, and industrial collaboration.Read moreRead less
Sustainable reform of the Murray-Darling system: Property rights, uncertainty and institutions. The project will develop tools for the modelling of uncertainty in the absence of probabilities and with imperfect knowledge about possible events. It will also formalise and assess the precautionary principle for the sustainable management of complex systems. Finally, the project will apply these tools to analyse and improve policies for the reform of property rights, institutions and land and water ....Sustainable reform of the Murray-Darling system: Property rights, uncertainty and institutions. The project will develop tools for the modelling of uncertainty in the absence of probabilities and with imperfect knowledge about possible events. It will also formalise and assess the precautionary principle for the sustainable management of complex systems. Finally, the project will apply these tools to analyse and improve policies for the reform of property rights, institutions and land and water management in the Murray?Darling system. The project will assist in the formulation of sustainable responses to problems of drought and irrigation related salinity in the Murray?Darling system.Read moreRead less
Group actions: combinatorics, geometry and computation. Science today relies on digital technologies using quantised and digital information. Because of the discrete nature of digital information, much of the mathematics underpinning these advances comes from the core disciplines of algebra and combinatorics within which this proposal falls. All aspects of the proposal focus on strengthening theoretical understanding of algebraic and combinatorial structures, and increasing computational power f ....Group actions: combinatorics, geometry and computation. Science today relies on digital technologies using quantised and digital information. Because of the discrete nature of digital information, much of the mathematics underpinning these advances comes from the core disciplines of algebra and combinatorics within which this proposal falls. All aspects of the proposal focus on strengthening theoretical understanding of algebraic and combinatorial structures, and increasing computational power for working with them. The fundamental research outcomes, in terms of theorems, algorithms, and the training of young research mathematicians, will thus both enhance the high international standing of Australian mathematics, and strengthen Australia's capabilities in these important areas.Read moreRead less
Exploring the Frontiers of Feasible Computation. The project aims to delineate the boundary between feasible and infeasible computational problems. A problem is considered feasible if there is an algorithm to solve it in worst-case time bounded by a polynomial in the input size. This is probably impossible for the important class of NP-complete problems. However, typical examples of NP-complete problems can often be solved in polynomial time, because worst-case problems are rare. The project is ....Exploring the Frontiers of Feasible Computation. The project aims to delineate the boundary between feasible and infeasible computational problems. A problem is considered feasible if there is an algorithm to solve it in worst-case time bounded by a polynomial in the input size. This is probably impossible for the important class of NP-complete problems. However, typical examples of NP-complete problems can often be solved in polynomial time, because worst-case problems are rare. The project is relevant to public-key cryptography, where breaking an encryption scheme should be infeasible, and to many real-life situations where NP-complete problems need to be solved, either exactly or approximately.Read moreRead less
Robust and Distributed Control of Quantum Systems. Australia has considerable strengths in quantum technology research. As these technologies advance, the issue of control and in particular feedback control becomes a critical one. This research project will strengthen Australia's position in quantum technology by developing new methodologies for designing high performance robust and distributed feedback controllers for quantum systems. The project will also add to Australia's strength in quantum ....Robust and Distributed Control of Quantum Systems. Australia has considerable strengths in quantum technology research. As these technologies advance, the issue of control and in particular feedback control becomes a critical one. This research project will strengthen Australia's position in quantum technology by developing new methodologies for designing high performance robust and distributed feedback controllers for quantum systems. The project will also add to Australia's strength in quantum technology by contributing to the research training of young researchers with expertise both in control systems engineering and quantum technology. This project will help Australia reap the maximum possible benefit from the new industries to emerge from the field of quantum technology.Read moreRead less
Engineering Nanostructured Bio-inspired Products. New nanostructured products that draw on biology promise to revolutionise our lives and economy. Designer emulsions and self-assembling particles inspired by viruses are two such products that form the focus for this research programme. The constitutive behaviour of bio-molecular films that control emulsion performance will be characterised and linked to molecular properties and manufacturing conditions. A broad-based technology platform for t ....Engineering Nanostructured Bio-inspired Products. New nanostructured products that draw on biology promise to revolutionise our lives and economy. Designer emulsions and self-assembling particles inspired by viruses are two such products that form the focus for this research programme. The constitutive behaviour of bio-molecular films that control emulsion performance will be characterised and linked to molecular properties and manufacturing conditions. A broad-based technology platform for the in vitro creation of self-assembling biological nanoparticles will also be developed. Key outcomes will be valuable IPR and fundamental engineering science knowledge to ensure that the value chain for this class of products can deliver commercial outcomes.Read moreRead less
Structural neurobiology - developing a new capability in Australia to treat mental illness. Mental illness encompasses a multitude of devastating conditions that present a major burden to the Australian economy. In this project powerful tools for determining the three-dimensional shapes and functions of proteins will be utilised to gain new knowledge about the molecular bases of various mental illnesses. The project will involve extensive use of the Australian Synchrotron Facility that is due to ....Structural neurobiology - developing a new capability in Australia to treat mental illness. Mental illness encompasses a multitude of devastating conditions that present a major burden to the Australian economy. In this project powerful tools for determining the three-dimensional shapes and functions of proteins will be utilised to gain new knowledge about the molecular bases of various mental illnesses. The project will involve extensive use of the Australian Synchrotron Facility that is due to open in 2007. This knowledge gained from the project will be used to develop new therapeutic drugs to ameliorate or combat mental diseases in partnership with the Australian Biotechnology Industry.Read moreRead less
Rethinking Mental Health Laws: An Integrated Approach. Mental health is one of the Commonwealth Government's national health priority areas. This research program will ensure the best possible outcomes for the Government's five-year action plan for better mental health services by developing model legal frameworks that will help shape the way in which individuals with mental illnesses can access the highest attainable standard of mental health care. Through interdisciplinary collaboration and th ....Rethinking Mental Health Laws: An Integrated Approach. Mental health is one of the Commonwealth Government's national health priority areas. This research program will ensure the best possible outcomes for the Government's five-year action plan for better mental health services by developing model legal frameworks that will help shape the way in which individuals with mental illnesses can access the highest attainable standard of mental health care. Through interdisciplinary collaboration and through developing model frameworks for both civil commitment and sentencing laws, this program will enable Australia to set the international agenda as to how countries can best respond to the mental health needs of their citizens.Read moreRead less