Optimal electromaterial structures for energy applications. This project aims to develop new mathematical and modelling approaches to determine optimal configurations and parameters for material structures created from three-dimensional printing of combined metals and electromaterials. Electromaterials are needed for sustainable energy, but solving coupled-systems of highly nonlinear governing equations is needed for optimal control of spatial arrangement and composition in nano and micro-struct ....Optimal electromaterial structures for energy applications. This project aims to develop new mathematical and modelling approaches to determine optimal configurations and parameters for material structures created from three-dimensional printing of combined metals and electromaterials. Electromaterials are needed for sustainable energy, but solving coupled-systems of highly nonlinear governing equations is needed for optimal control of spatial arrangement and composition in nano and micro-structural domains. Dealing with this mathematical complexity is critical to developing high efficiency energy generation and gas storage systems. This is expected to enhance transport mechanisms within electrochemical devices and create opportunities for industry to use electrofunctional materials.Read moreRead less
Saving energy on trains - demonstration, evaluation, integration. Reducing energy use from rail transport will significantly contribute to cutting carbon dioxide emissions. This project will develop a toolkit to facilitate the introduction of in-cab technologies that help train drivers save energy and stay on time. The toolkit will make it easier to demonstrate, evaluate and integrate the system in a range of railways.
Discovery Early Career Researcher Award - Grant ID: DE240100097
Funder
Australian Research Council
Funding Amount
$389,670.00
Summary
Mathematical models for actin scavenging and biofilm removal. The project aims to develop mathematical models for actin scavenging and biofilm removal, processes that combine to alleviate tissue damage and inflammation. Actin scavenging eliminates the protein F-actin which is released during cell death, but this process is not fully-understood. Biofilms are colonies of micro-organisms, for example bacteria, that are highly resistant to antimicrobial treatment. This project expects to generate ne ....Mathematical models for actin scavenging and biofilm removal. The project aims to develop mathematical models for actin scavenging and biofilm removal, processes that combine to alleviate tissue damage and inflammation. Actin scavenging eliminates the protein F-actin which is released during cell death, but this process is not fully-understood. Biofilms are colonies of micro-organisms, for example bacteria, that are highly resistant to antimicrobial treatment. This project expects to generate new knowledge, using an innovative combination of mathematical modelling and cell biology experiments. Expected outcomes include new theory and software, yielding the benefits of increased understanding of cell biology, and potential to enhance development of smart materials that eliminate biofilms.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100031
Funder
Australian Research Council
Funding Amount
$333,684.00
Summary
Mathematical modelling of the complex mechanics of biological materials and their role in tissue function and development. The mechanics of biological materials is complicated because they consist of many components such as fibres, proteins and polymers. We aim to use mathematical tools to understand how these components interact in tissues such as the spinal disc which will aid the development of new treatments to reverse the effects of injury, disease or aging.
Liquidity in financial markets. This project aims to develop a theory which models the effect of liquidity on option prices under different market conditions. Economic or financial crises are inevitable and affect economics. During or after a major financial crisis, market liquidity usually becomes risky and needs to be studied. Through both empirical and theoretical explorations, this project will quantify and measure liquidity risk and its effect on the options markets. It will develop a frame ....Liquidity in financial markets. This project aims to develop a theory which models the effect of liquidity on option prices under different market conditions. Economic or financial crises are inevitable and affect economics. During or after a major financial crisis, market liquidity usually becomes risky and needs to be studied. Through both empirical and theoretical explorations, this project will quantify and measure liquidity risk and its effect on the options markets. It will develop a framework to help market regulators manage illiquidity, enhance the efficiency of option trading in illiquid markets and help in the detection of market manipulation.Read moreRead less
Understanding the mechanisms that inhibit and promote biofilm expansion. Yeasts have been used for biotechnology throughout recorded history. They are important human pathogens, and major experimental models of eukaryotic cells. Although yeasts are some of the most studied organisms in biology, their modes of colony biofilm formation are not fully understood. Methods to investigate the environmental and genetic processes that drive colony biofilm formation will be developed in this proposed pro .... Understanding the mechanisms that inhibit and promote biofilm expansion. Yeasts have been used for biotechnology throughout recorded history. They are important human pathogens, and major experimental models of eukaryotic cells. Although yeasts are some of the most studied organisms in biology, their modes of colony biofilm formation are not fully understood. Methods to investigate the environmental and genetic processes that drive colony biofilm formation will be developed in this proposed project. They will provide a deeper understanding of the mechanisms that inhibit and promote biofilm formation, and colonial morphology in the different modes of growth of Saccharomyces cerevisiae, with implications for this and other biofilm-forming yeasts of biotechnological or medical importance.Read moreRead less
Quantifying yeast cell mechanisms: filamentous growth and biofilm formation. This project aims to quantify the cellular mechanisms of yeast growth to advance our understanding of these organisms and support strategies to prevent and treat disease. Although yeasts are some of the most studied organisms in biology, their modes of filamentous growth and biofilm formation are not fully understood. Yeasts such as the Candida species cause potentially lethal infections through filamentous invasion of ....Quantifying yeast cell mechanisms: filamentous growth and biofilm formation. This project aims to quantify the cellular mechanisms of yeast growth to advance our understanding of these organisms and support strategies to prevent and treat disease. Although yeasts are some of the most studied organisms in biology, their modes of filamentous growth and biofilm formation are not fully understood. Yeasts such as the Candida species cause potentially lethal infections through filamentous invasion of tissues. The project plans to develop methods to quantify the mechanisms driving these growth processes. These methods will be designed to permit classification and selection of strain-specific properties of yeasts, providing a deeper understanding of the mechanisms controlling cellular and colonial morphology in the growth of Saccharomyces cerevisiae, the most important yeast in both biotechnology and bioscience.Read moreRead less
Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of internation ....Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of international collaborations with Europe and Japan; (iii) outcomes will ultimately impact on improved medical bionics and future interfaces between brain activity and machines or computers; and (iv) commercialization and technology transfer opportunities, via the transfer of results to biologically inspired engineering.Read moreRead less
Suspension flows and particle focusing in curved geometries. The project aims to develop fast predictive tools to investigate suspension flows in curved channels and thin ducts and the effect of channel geometry on the focusing of particles by weight to different regions of the channel. Interaction between particles and fluid in suspension flows is a fundamental problem that is little understood but which is important in a wide range of problems in nature and industry (eg for design of microscal ....Suspension flows and particle focusing in curved geometries. The project aims to develop fast predictive tools to investigate suspension flows in curved channels and thin ducts and the effect of channel geometry on the focusing of particles by weight to different regions of the channel. Interaction between particles and fluid in suspension flows is a fundamental problem that is little understood but which is important in a wide range of problems in nature and industry (eg for design of microscale segregation devices for separation of different cells in a blood sample, and of macroscale devices for separation of mineral particles from crushed ore). At present, the description of these processes is qualitative, with quantitative understanding seen as a challenge without intensive computation. The project plans to develop, solve and validate mathematical models to give a quantitative understanding of these processes.Read moreRead less
Prediction of inertial particle focusing in curved microfluidic ducts. This project aims to develop mathematical models to predict migration of particles suspended in flow through curved microfluidic ducts and their focusing by size to different regions in the cross-section of the duct. New knowledge in mathematics and engineering will be generated through models that capture the two-way force balance between fluid and particles and by a novel use of asymptotics for computational efficiency. Exp ....Prediction of inertial particle focusing in curved microfluidic ducts. This project aims to develop mathematical models to predict migration of particles suspended in flow through curved microfluidic ducts and their focusing by size to different regions in the cross-section of the duct. New knowledge in mathematics and engineering will be generated through models that capture the two-way force balance between fluid and particles and by a novel use of asymptotics for computational efficiency. Expected outcomes are understanding of the physics that drives particle migration and the parameters that may be used to control particle focusing. This will benefit design and operation of microfluidic devices for particle sorting as required for "liquid biopsy", the isolation of cancer cells in a routine blood sample.Read moreRead less