New Developments for Bayesian statistical models and computational methods. Bayesian methods of statistical analysis provide a flexible theory for addressing inference in the presence of uncertainty. Consequently Bayesian methods have enabled scientific discovery in areas characterised as complex systems where new developments in modelling and computational methods have been crucial. Significant barriers to further success involve challenges in formulating and validating models, dealing with l ....New Developments for Bayesian statistical models and computational methods. Bayesian methods of statistical analysis provide a flexible theory for addressing inference in the presence of uncertainty. Consequently Bayesian methods have enabled scientific discovery in areas characterised as complex systems where new developments in modelling and computational methods have been crucial. Significant barriers to further success involve challenges in formulating and validating models, dealing with large data sets, and developing efficient computational methods. The principal aim of this project is to develop new Bayesian modelling and computational methodology which address these challenges with broad application.Read moreRead less
Efficient Pre-Processing of Hard Problems: New Approaches, Basic Theory and Applications. Computers store even larger amounts of data about all aspects of human and industrial activity. However, they have not become significantly better at solving common problems in optimization and search. Traditional complexity theory indicates many of these problems require algorithms that are very unlikely to exist. The Parameterized Complexity approach allows us to obtain very efficient algorithms for a lar ....Efficient Pre-Processing of Hard Problems: New Approaches, Basic Theory and Applications. Computers store even larger amounts of data about all aspects of human and industrial activity. However, they have not become significantly better at solving common problems in optimization and search. Traditional complexity theory indicates many of these problems require algorithms that are very unlikely to exist. The Parameterized Complexity approach allows us to obtain very efficient algorithms for a large variety of problems, but the machinery required was diverse and complicated. This research will organize the machinery into a new approach that systematically finds good algorithms by applying simplifications around a parameter of the domain of the problem. As a result, efficient algorithms are obtained for many diverse areas.Read moreRead less
A toolkit of statistical methodology for a state-of-the-art software and decision support system for forest assessment using new airborne data. The aim is to develop statistical methods for efficient collection and interpretation of airborne laser data and videography, used to describe characteristics of the forest such as tree species, stand history and vertical distribution of foliage, and hence biodiversity and biomass. This is significant for meeting Australia's international and national en ....A toolkit of statistical methodology for a state-of-the-art software and decision support system for forest assessment using new airborne data. The aim is to develop statistical methods for efficient collection and interpretation of airborne laser data and videography, used to describe characteristics of the forest such as tree species, stand history and vertical distribution of foliage, and hence biodiversity and biomass. This is significant for meeting Australia's international and national environmental obligations, providing quality information to farmers and industry, and hence developing potential jobs in regional areas. Outcomes include a toolkit of statistical methods applicable to spatial modelling and analysis of very large datasets, a statistically valid software product, marketable estimation methods in carbon accounting, technology transfer, training, publications.Read moreRead less
Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinic ....Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinical trials for possible effective treatments of neurological diseases such as motor neurone disease to be conducted with an objective measurement of disease progression. Read moreRead less
High Resolution EPR Spectroscopy - A Tool for Determining Electronic and Geometric Structure of Metalloenzymes. High resolution orientation selective pulsed EPR and END(T)OR in conjunction with computer simulation (XSophe) and computational chemistry will allow the determination of the electronic and geometric structure (distance and orientation of nuclei surrounding the metal ion(s)) of multiple redox centres in DMSOR, DorC and DMSDH to be determined. In addition pulsed ELDOR in conjunction wi ....High Resolution EPR Spectroscopy - A Tool for Determining Electronic and Geometric Structure of Metalloenzymes. High resolution orientation selective pulsed EPR and END(T)OR in conjunction with computer simulation (XSophe) and computational chemistry will allow the determination of the electronic and geometric structure (distance and orientation of nuclei surrounding the metal ion(s)) of multiple redox centres in DMSOR, DorC and DMSDH to be determined. In addition pulsed ELDOR in conjunction with molecular modelling will enable the mapping (distance and orientation) of redox centres in complex multicentered metalloproteins (DMSDH and DorC) and in protein-protein complexes (DMSOR-DorC) providing information on the pathway of electron transfer and hence the role of the pyranopterins.Read moreRead less
ARC Centre for Complex Dynamic Systems & Control. Complex dynamic systems are an inescapable feature of the world we live in. Modelling, analysing and optimizing complex behaviour is crucial for environment, process industry, biomedical, energy distribution, transportation and other applications. The Centre for Complex Dynamic Systems and Control will become an international authority in the analysis, design and optimization of complex dynamic systems, pursuing both outstanding fundamental and c ....ARC Centre for Complex Dynamic Systems & Control. Complex dynamic systems are an inescapable feature of the world we live in. Modelling, analysing and optimizing complex behaviour is crucial for environment, process industry, biomedical, energy distribution, transportation and other applications. The Centre for Complex Dynamic Systems and Control will become an international authority in the analysis, design and optimization of complex dynamic systems, pursuing both outstanding fundamental and cutting edge applied research outcomes. These outcomes will be of specific benefit to partner organizations including minerals, process, metal forming, and automotive industries.Read moreRead less
Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most ....Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most industries in Australia. More specifically, it is to be applied here to the diagnosis and prognosis of ovarian cancer. This cross-disciplinary project will strengthen Australian researchers' capacity and capability of participating in cutting-edge DNA microarray research.
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Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress ....Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress in a feasible time frame. In three dimensions this project will strengthen the distinguished computational topology community in Melbourne, led by pioneers such as Rubinstein, Goodman, Hodgson as well as the applicant himself.Read moreRead less
Elicitation and Integration of Expert Information for Natural Resource Management with a Focus on Water. Australia's natural resource management requires integrating information from many sources, including survey data and community and expert opinion. We aim to develop statistical methods to formally combine this information and apply them to better management of our crucial resource, water. The project contributes significantly to Australia's international obligations, and government agency an ....Elicitation and Integration of Expert Information for Natural Resource Management with a Focus on Water. Australia's natural resource management requires integrating information from many sources, including survey data and community and expert opinion. We aim to develop statistical methods to formally combine this information and apply them to better management of our crucial resource, water. The project contributes significantly to Australia's international obligations, and government agency and regional group science-based decision-making.
Outcomes include increased fundamental knowledge in statistics, technology transfer and improved decision-making capacity for natural resource management.
The project builds on strong existing collaborations between academic and industry partners and provides foundation for future funded projects.
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Measuring and presenting uncertainty in complex natural resource monitoring programs. This project addresses Australia's key research goal of An Environmentally Sustainable Australia, priority goals of Water, Soil and Climate, and the theme of Complex Systems.Through improved capability in making data-based decisions and true sharing of university and government agency expertise, the project will enhance Australia's ability to better manage its natural resources, meet national and international ....Measuring and presenting uncertainty in complex natural resource monitoring programs. This project addresses Australia's key research goal of An Environmentally Sustainable Australia, priority goals of Water, Soil and Climate, and the theme of Complex Systems.Through improved capability in making data-based decisions and true sharing of university and government agency expertise, the project will enhance Australia's ability to better manage its natural resources, meet national and international environmental commitments, and address national demands for quality science underpinning decisions about natural resource managementRead moreRead less