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I will determine the efficacy and safety of crystalloid resuscitation fluids in conventional models of care. This is a fundamental and unresolved question in Intensive Care Medicine and will have an impact on clinical practice worldwide. I will also consolidate and enhance a series of projects to provide the next generation of clinician-researchers with high-quality research opportunities. These include projects in sepsis, traumatic brain injury, and endocrine function in critical illness.
Epidemiological And Economic Modelling Of Diabetes And Its Complications In The Contemporary Australian Setting.
Funder
National Health and Medical Research Council
Funding Amount
$85,827.00
Summary
Diabetes imposes a significant health and economic burden on Australia. This burden is set to increase as the population becomes older and risk factors for diabetes, such as obesity, become more common. The main aims of the proposed project are: 1. To develop computer-based models that will predict future patterns of diabetes and its complications in Australia. 2. To use these models to determine effective and cost-effective ways to reduce the future burden of diabetes in Australia.
A Life Course Approach To Improving The Health And Well-being Of Young People With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$193,360.00
Summary
Children with kidney disease suffers from profound ill-health and adopt a restrictive lifestyle, including dietary restriction, absences from school and other co-curricular activities. New knowledge and interventions are needed to address the pressing needs including of these children and their caregivers. This program of work will adopt a life-course approach to determine the protective and risk factors that affect the overall health and well-being of children with chronic kidney disease.
Culture-independent Microbiology: Reducing Delays In The Diagnosis Of Severe Infections And Detection Of Antimicrobial Resistance From Days To Hours.
Funder
National Health and Medical Research Council
Funding Amount
$949,589.00
Summary
Serious infections require early effective antibiotic treatment. To provide evidence that an antibiotic will be effective, current tests take 2-5 days and this leads to a reliance on broad spectrum antibiotics, which can cause harm. Our new diagnostic methods, can produce results in 4-6 hours. We will demonstrate the real-world benefit of these methods by assessing samples taken from patients with three high risk infections and compare our test to currently available results.
Clinical Utility And Cost-effectiveness Of Genome Sequencing For Refractory Epilepsy In Children And Adults: A Multicentre Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$720,609.00
Summary
A large number of genomic variants have been found to underpin common types of epilepsy and to predict adverse drug reactions. However, the adoption of genomic testing in the routine management of epilepsy is hampered by uncertainties around its clinical utility and cost-effectiveness. This randomised controlled trial aims to determine the diagnostic efficiency, clinical and psychosocial impact, and cost-effectiveness of whole genome sequencing for refractory epilepsy in children and adults.
Stillbirth is a global public health problem. In Australia, almost 3,000 stillbirths occur each year and death places a significant psychological burden on parents, families and caregivers. The community impacts through social and economic costs are also substantial. Many stillbirths are preventable with known and novel interventions. Through a CRE dedicated to stillbirth, we aim to strengthen our collaborations locally and internationally, and reduce stillbirth, and improve care for parents.
A Randomised Trial Of A Carer End Of Life Planning Intervention (CELPI) In People Dying With Dementia
Funder
National Health and Medical Research Council
Funding Amount
$1,486,232.00
Summary
Dementia is the second highest cause of death in Australia. Although palliative care helps individuals avoid suffering and futile interventions at the end of life, only 6% of people that die of dementia receive such care. Many older people with dementia attend an ED in their final year of life. In CELPI we will trial using that opportunity of an ED visit as the trigger to implement a triad of carer education, access to palliative care and a formal planning process for participants.