Discovery Early Career Researcher Award - Grant ID: DE200100200
Funder
Australian Research Council
Funding Amount
$418,398.00
Summary
Next generation causal inference methods for biological data. This project aims to develop next generation causal inference methods for analysing biological data especially the single cell sequencing data and their applications in cell biology. Although Artificial Intelligence and Statistical Machine Learning have been applied successfully in many fields, including biological research, there is still a serious lack of methods for interpreting and reasoning about the mechanism of biological syste ....Next generation causal inference methods for biological data. This project aims to develop next generation causal inference methods for analysing biological data especially the single cell sequencing data and their applications in cell biology. Although Artificial Intelligence and Statistical Machine Learning have been applied successfully in many fields, including biological research, there is still a serious lack of methods for interpreting and reasoning about the mechanism of biological systems, the ultimate goal of research in many areas. Efficient data-driven causality discovery approaches developed by the project will be a timely and significant contribution to the knowledge of biology and statistics as well as the battle against health threats.
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Modelling mean and dispersion using fixed and random effects. The aims of the project are to develop methods for joint mean and dispersion modelling using fixed and random effects, in the generalized linear models context and for Gaussian longitudinal data. The significance is the more efficient, precise and appropriate analysis of data arising from many areas of application. The expected outcomes are therefore better methods of analysis, software to carry the analyses out, and potentially impor ....Modelling mean and dispersion using fixed and random effects. The aims of the project are to develop methods for joint mean and dispersion modelling using fixed and random effects, in the generalized linear models context and for Gaussian longitudinal data. The significance is the more efficient, precise and appropriate analysis of data arising from many areas of application. The expected outcomes are therefore better methods of analysis, software to carry the analyses out, and potentially important results in applications.Read moreRead less
Classification methods for providing personalised and class decisions. This project provides a novel approach to the clustering of multivariate samples on entities in a class that automatically matches the sample clusters across the entities, allowing for inter-sample variation between the samples in a class. The project aims to develop a widely applicable, mixture-model-based framework for the simultaneous clustering of multivariate samples with inter-sample variation in a class and for the mat ....Classification methods for providing personalised and class decisions. This project provides a novel approach to the clustering of multivariate samples on entities in a class that automatically matches the sample clusters across the entities, allowing for inter-sample variation between the samples in a class. The project aims to develop a widely applicable, mixture-model-based framework for the simultaneous clustering of multivariate samples with inter-sample variation in a class and for the matching of the clusters across the entities in the class. The project will use a statistical approach to automatically match the clusters, since the overall mixture model provides a template for the class. It will provide a basis for discriminating between different classes in addition to the identification of atypical data points within a sample and of anomalous samples within a class. Key applications include biological image analysis and the analysis of data in flow cytometry which is one of the fundamental research tools for the life scientist.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101565
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Flexible data modelling via skew mixture models:challenges and applications. This project seeks to explore new models for handling data with non-normal features. Parametric distributions are fundamental to statistical modelling and inference. For centuries, the ‘normal’ distribution has been the dominant model for continuous data. However, real data rarely satisfy the assumption of normality. There is thus a strong demand for more flexible distributions. This project aims to develop new methodol ....Flexible data modelling via skew mixture models:challenges and applications. This project seeks to explore new models for handling data with non-normal features. Parametric distributions are fundamental to statistical modelling and inference. For centuries, the ‘normal’ distribution has been the dominant model for continuous data. However, real data rarely satisfy the assumption of normality. There is thus a strong demand for more flexible distributions. This project aims to develop new methodologies in finite mixture modelling using skew component distributions to provide better models for handling data with non-normal features (such as skewness, heavy/light tails, and multimodality). Applications may include security intrusion detection, clinical diagnosis and prognosis, and flow and mass cytometry.Read moreRead less
Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Pr ....Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Project will develop novel designs for microarray experiments and focus on the advancement of topics crucial to Australia's success in technological research.
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WaterLog - A mathematical model to implement recommendations of The Wentworth Group. In 2003, The Wentworth Group of Concerned Scientists released their 'Blueprint for a national water plan' with the primary objective to 'protect river health and the rights of all Australians to clean usable water'. Currently, there are significant water restrictions in all the Australian mainland capital cities. In January 2007, the Prime Minister of Australia, announced a bold plan to rescue the Murray-Darling ....WaterLog - A mathematical model to implement recommendations of The Wentworth Group. In 2003, The Wentworth Group of Concerned Scientists released their 'Blueprint for a national water plan' with the primary objective to 'protect river health and the rights of all Australians to clean usable water'. Currently, there are significant water restrictions in all the Australian mainland capital cities. In January 2007, the Prime Minister of Australia, announced a bold plan to rescue the Murray-Darling Basin. The plan incorporates political management changes, and an investment of $10Bn. Now is the time to develop improved techniques for management of water storage systems. This project will develop the fundamental mathematical principles required for this improved management.Read moreRead less
Perturbations in Complex Systems and Games. This project aims to: advance the perturbation theory of dynamic and stochastic games; further develop approximations of infinite dimensional linear programs by their finite dimensional counterparts, and by finding asymptotic limits of spaces of occupational measures, by solution of successive layers of fundamental equations; explain and quantify the "exceptionality" of instances of systems that are genuinely difficult to solve; and, capitalise on the ....Perturbations in Complex Systems and Games. This project aims to: advance the perturbation theory of dynamic and stochastic games; further develop approximations of infinite dimensional linear programs by their finite dimensional counterparts, and by finding asymptotic limits of spaces of occupational measures, by solution of successive layers of fundamental equations; explain and quantify the "exceptionality" of instances of systems that are genuinely difficult to solve; and, capitalise on the outstanding performance of our Snakes-and-Ladders Heuristic (SLH) for the solution of the Hamiltonian cycle problem to identify its "fixed complexity orbits" and generalise this notion to other NP-complete problems.Read moreRead less
Computational methods for population-size-dependent branching processes. Branching processes are the primary mathematical tool used to model populations that evolve randomly in time. Most key results in the theory are derived under the simplifying assumption that individuals reproduce and die independently of each other. However, this assumption fails in most real-life situations, in particular when the environment has limited resources or when the habitat has a restricted capacity. This project ....Computational methods for population-size-dependent branching processes. Branching processes are the primary mathematical tool used to model populations that evolve randomly in time. Most key results in the theory are derived under the simplifying assumption that individuals reproduce and die independently of each other. However, this assumption fails in most real-life situations, in particular when the environment has limited resources or when the habitat has a restricted capacity. This project aims to develop novel and effective algorithmic techniques and statistical methods for a class of branching processes with dependences. We will use these results to study significant problems in the conservation of endangered island bird populations in Oceania, and to help inform their conservation management.Read moreRead less
ARC Centre of Excellence for Mathematical and Statistical Frontiers of Big Data, Big Models, New Insights. In today's world, massive amounts of data in a variety of forms are collected daily from a multitude of sources. Many of the resulting data sets have the potential to make vital contributions to society, business and government, as well as impact on international developments, but are so large or complex that they are difficult to process and analyse using traditional tools. The aim of this ....ARC Centre of Excellence for Mathematical and Statistical Frontiers of Big Data, Big Models, New Insights. In today's world, massive amounts of data in a variety of forms are collected daily from a multitude of sources. Many of the resulting data sets have the potential to make vital contributions to society, business and government, as well as impact on international developments, but are so large or complex that they are difficult to process and analyse using traditional tools. The aim of this Centre is to create innovative mathematical and statistical models that can uncover the knowledge concealed within the size and complexity of these big data sets, with a focus on using the models to deliver insight into problems vital to the Centre's Collaborative Domains: Healthy People, Sustainable Environments and Prosperous Societies.Read moreRead less