The effect of age on regulatory T cell control of the innate and adaptive antiviral immune responses. Viral pathogens are a lead cause of infant mortality in the world. This project will define how T regulatory cells limit protective antiviral immune responses in the young. This information is critical for the development of potent antiviral vaccines that are effective from the newborn period without inducing autoimmunity. It will also provide novel insight into the way T regulatory cells can b ....The effect of age on regulatory T cell control of the innate and adaptive antiviral immune responses. Viral pathogens are a lead cause of infant mortality in the world. This project will define how T regulatory cells limit protective antiviral immune responses in the young. This information is critical for the development of potent antiviral vaccines that are effective from the newborn period without inducing autoimmunity. It will also provide novel insight into the way T regulatory cells can be manipulated both to dampen immunity, which can be used to develop strategies to reduce immune mediated disease and limit transplant rejection. Read moreRead less
A New Model for 3D Migration Involving Claw Structures and Metalloproteinases. This proposal will revolutionize ideas related to cell movement through three-dimensional (3D) matrix. Our method in mimicking the body's dense 3D matrix environment have led to the discovery of a new cell structure called Claws, and the formulation of a new model for 3D invasion in high density matrix. We will study the genes that control this type of migration including those involved in the formation of the cell fr ....A New Model for 3D Migration Involving Claw Structures and Metalloproteinases. This proposal will revolutionize ideas related to cell movement through three-dimensional (3D) matrix. Our method in mimicking the body's dense 3D matrix environment have led to the discovery of a new cell structure called Claws, and the formulation of a new model for 3D invasion in high density matrix. We will study the genes that control this type of migration including those involved in the formation of the cell front (Claw region), the back of the cells and matrix digestion. This work will have significant impact on normal and pathological human conditions from immune responses to tissue regeneration and cancer.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989744
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
7-laser BD LSR-II and Cellomics ArrayScan VTi, to enhance capability and throughput for the NSW Advanced Cytometry Facility. The scientific advances that will be possible with the acquisition of these complementary cutting-edge instruments will enhance the research outputs of all investigators using it. Projects where investigation of either suspended or adherent live cells is used to elucidate basic life processes of eukaryotic cells across all species of animals, including the investigation of ....7-laser BD LSR-II and Cellomics ArrayScan VTi, to enhance capability and throughput for the NSW Advanced Cytometry Facility. The scientific advances that will be possible with the acquisition of these complementary cutting-edge instruments will enhance the research outputs of all investigators using it. Projects where investigation of either suspended or adherent live cells is used to elucidate basic life processes of eukaryotic cells across all species of animals, including the investigation of both normal and abnormal function, will be immeasurably enhanced by both the qualitative and quantitative statistical information about these processes that is generated by this instrumentation. This in turn will inform new approaches to improve and maintain the health of both humans and animals.Read moreRead less