Studies Into Myeloperoxidase-Induced Cardiovascular Disease And Its Treatment
Funder
National Health and Medical Research Council
Funding Amount
$924,596.00
Summary
During cardiovascular disease an inflammatory protein called myeloperoxidase (MPO) becomes abnormally released into the circulating blood and is transported into diseased blood vessels. Our studies show for the first time that increasing circulating levels of MPO promotes both atherosclerosis and aortic aneurysm. This project will study how MPO promotes inflammatory artery disease and test new drugs for their ability to inhibit this damaging protein and protect against cardiovascular disease.
Examination Of A Novel Pathway For Artery Weakening
Funder
National Health and Medical Research Council
Funding Amount
$698,300.00
Summary
Approximately 5% of men and 1% of women aged over 60 years develop weakening of the main abdominal artery. Currently the management of artery weakening is focused on surgery with no effective medications available. In this study we will assess the role of a novel pathway in artery weakening. Improved understanding of the mechanisms causing artery degeneration is crucial to target the development of better ways to treat this common problem.
Upregulating Kallistatin To Limit Abdominal Aortic Aneurysm.
Funder
National Health and Medical Research Council
Funding Amount
$668,974.00
Summary
Artery weakening or aneurysm is an important cause of mortality in older adults. Currently there are only surgical therapies for artery weakening. Novel drug therapies are needed for artery weakening. In this project the role of a protein which may inhibit artery weakening is investigated. We also investigate the role of a drug to modulate this protein. The project will include studies in pre-clinical models and a pilot clinical trial in patients.
Approximately 7% of elderly men have an abdominal aortic aneurysm (AAA) and AAA rupture usually results in death. This research aims to improve the limitations in AAA risk assessment. Currently, the maximum diameter determines if the aneurysm is at risk of rupture. However, many small AAAs rupture and 75% of larger ones never burst. Using computer models generated from medical imaging can substantially improve the understanding of rupture risk, therefore, saving lives and reducing health care co ....Approximately 7% of elderly men have an abdominal aortic aneurysm (AAA) and AAA rupture usually results in death. This research aims to improve the limitations in AAA risk assessment. Currently, the maximum diameter determines if the aneurysm is at risk of rupture. However, many small AAAs rupture and 75% of larger ones never burst. Using computer models generated from medical imaging can substantially improve the understanding of rupture risk, therefore, saving lives and reducing health care costs.Read moreRead less
The Role Of Angiotensin Converting Enzyme 2 In Limiting Complications Of Aortic Aneurysm.
Funder
National Health and Medical Research Council
Funding Amount
$684,989.00
Summary
Artery weakening or aneurysm is an important cause of mortality in older adults. Currently there are only surgical therapies for artery weakening. In this project the role of a protein which may inhibit artery weakening is investigated. In this project we assess if targeting this protein could limit artery weakening using pre-clinical models.
“Beyond The Tape Measure” - Measuring The Impact Of Abnormal Flow Dynamics On Dilation Of The Ascending Aorta.
Funder
National Health and Medical Research Council
Funding Amount
$723,771.00
Summary
Dilation of the ascending aorta is an important cause of death, leading to aortic rupture and dissection. The rate of complications has not improved in two decades, because our ability to detect and predict disease has not changed. This project will use 4D flow and other types of cutting edge magnetic resonance imaging to address this clinical need, building knowledge regarding the abnormal flows that cause aortic dilatation, enabling earlier diagnosis and providing new insights.
Blocking The Factor XII- Kallikrein Pathway To Limit Abdominal Aortic Aneurysm
Funder
National Health and Medical Research Council
Funding Amount
$686,995.00
Summary
Artery weakening is present in 2-5% of older adults and is an important cause of sudden death. The investigators have generated substantial preliminary data from a previous NHMRC project implicating the contact pathway in the process of artery weakening. In the current project the investigators will examine the ability of agents which are currently available or being developed for patient use in limiting the process of artery degeneration using established pre-clinical models.
Economic Evaluation And Optimisation Of Services For The Preoperative Assessment And Management Of High Risk Surgical Patients
Funder
National Health and Medical Research Council
Funding Amount
$399,406.00
Summary
Medical co-morbidities in surgical patients affect post-surgical recovery, resulting in higher health service costs and poorer patient outcomes. Preliminary data indicate reduced post-surgical length of stay for patients with modifiable risk factors who attended a specialist preoperative clinic. This project will analyse existing data to identify patient sub-groups with the greatest capacity to benefit from specialist preoperative assessment, and evaluate new service pathways for these patients.
Fenofibrate In The Management Of AbdoMinal Aortic AnEurysm (FAME)
Funder
National Health and Medical Research Council
Funding Amount
$455,713.00
Summary
Approximately 5% of men and 1% of women aged over 60 years develop weakening of the main abdominal artery. Currently the management of artery weakening is focused on surgery with no effective medications available. In this study we will assess whether a drug which limits artery weakening in pre-clinical testing also shows evidence of inhibiting processes important in artery damage in patients. We believe this is a critical next step in the assessment of a promising new treatment.
The Role Of The Clotting Cascade In Aortic Aneurysm And Associated Cardiovascular Events
Funder
National Health and Medical Research Council
Funding Amount
$651,173.00
Summary
Weakening of the main abdominal artery is responsible for approximately 1000 deaths/ year in Australia. Most weakened arteries are identified at an early stage but there is no current therapy which limits the progression of artery weakening. There is also no model which predicts the complications associated with weakened arteries. In the current project we propose the importance of clot in progression and complications of weakened arteries. We will undertake studies to identify new therapies and ....Weakening of the main abdominal artery is responsible for approximately 1000 deaths/ year in Australia. Most weakened arteries are identified at an early stage but there is no current therapy which limits the progression of artery weakening. There is also no model which predicts the complications associated with weakened arteries. In the current project we propose the importance of clot in progression and complications of weakened arteries. We will undertake studies to identify new therapies and a predictive model for weakened arteries.Read moreRead less