Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347223
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
Quantitative PCR facility for New England region of NSW. The project will deliver the first real-time PCR facility in the New England Region of NSW for use by University, CSIRO and Industry scientists. The facility will be based at the University of New England and be used by animal scientists, molecular biologists, parasitologists, immunologists and botanists at these institutions, in many cases in collaborative research projects. It will also support the training of seven PhD students and a po ....Quantitative PCR facility for New England region of NSW. The project will deliver the first real-time PCR facility in the New England Region of NSW for use by University, CSIRO and Industry scientists. The facility will be based at the University of New England and be used by animal scientists, molecular biologists, parasitologists, immunologists and botanists at these institutions, in many cases in collaborative research projects. It will also support the training of seven PhD students and a post-doctoral fellow. The facility will be unique to the region and will remove our current need to use facilities in Brisbane or Sydney.Read moreRead less
Manipulative mothers and family feuds: evolution of maternal effects under mother-offspring conflict. Can mothers shape the lives of their offspring and their grand-offspring? Can siblings shape the lives of their brothers and sisters? This project will address how mother and offspring strategies affect current and future generations. This is crucial for understanding how mothers will direct and accelerate evolutionary change in our changing world.
Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm. Fizzy-Related is a gene that appears to be essential in making an ovulated egg, and it may also have an important role to play in making sperm. A mouse knockout will be generated to examine exactly how it functions; because it affects the egg number remaining in the ovary and egg quality Fizzy-Related may be eventually an important therapeutic target.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Navigating brains: the neurobiology of spatial cognition. Navigation is one of the most crucial and most challenging problems animals face. Behavioural analyses have shown that animals make use of a number of different mechanisms to navigate, but very little is known of how different forms of spatial information are processed and integrated by the brain. The project aims to tackle this by placing tethered ants in a virtual-reality simulation of their real environment allowing precise control of ....Navigating brains: the neurobiology of spatial cognition. Navigation is one of the most crucial and most challenging problems animals face. Behavioural analyses have shown that animals make use of a number of different mechanisms to navigate, but very little is known of how different forms of spatial information are processed and integrated by the brain. The project aims to tackle this by placing tethered ants in a virtual-reality simulation of their real environment allowing precise control of visual navigational cues, as well as the opportunity to study the brains of the tethered ants as they solve the real-world challenge of finding home. This may reveal how simple brains efficiently solve navigational tasks, which may inform both cognitive biology and bio-inspired computation.Read moreRead less
Information processing at its limits: from the dimmest habitats to the smallest sizes. Ensuring optimal information processing at the limits of size and ambient light is a challenge for technical systems, but has been elegantly solved by animals. The challenge of navigation is similar for animals of all sizes and in both day and night. This project aims to conduct a comparative analysis to identify the consequence of size and light on the information processing capacities for visual navigation. ....Information processing at its limits: from the dimmest habitats to the smallest sizes. Ensuring optimal information processing at the limits of size and ambient light is a challenge for technical systems, but has been elegantly solved by animals. The challenge of navigation is similar for animals of all sizes and in both day and night. This project aims to conduct a comparative analysis to identify the consequence of size and light on the information processing capacities for visual navigation. Outcomes of this project will reveal the behavioural and physiological adaptations needed and the costs associated with navigating in the dimmest of habitats and at the smallest of sizes. Identifying such optimal biological solutions for robust navigation will be relevant for image processing, computer vision and robotics.Read moreRead less
Young people with cognitive disability: relationships and paid support. This project aims to improve the rights and wellbeing of young people with cognitive disability by exploring their relationship and interaction with paid support workers. The introduction of national individualised funding and support is a watershed in Australian disability policy. Understanding the role that paid support plays in the ongoing identity development of these young people is urgently needed to realise national p ....Young people with cognitive disability: relationships and paid support. This project aims to improve the rights and wellbeing of young people with cognitive disability by exploring their relationship and interaction with paid support workers. The introduction of national individualised funding and support is a watershed in Australian disability policy. Understanding the role that paid support plays in the ongoing identity development of these young people is urgently needed to realise national policy aspirations for people with disability of rights, choice, inclusion and independence. Using social geography and recognition theory, the project expects to deliver new understanding and improved practice around how paid support relationships can foster mutual care, respect and value at a critically important time in young people’s lives.Read moreRead less
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.