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Flea Control by Immunological Intervention. Fleas are bloodsucking parasites that are the major cause of skin disease in pets. Currently, all available flea products rely upon chemical control and many have active components that have real or perceived health problems. Given that insect growth regulators do not kill adult fleas and pet owners are interested in using alternatives to insecticides, there is a clear need for a complementary form of flea control. We describe the novel use of Prote ....Flea Control by Immunological Intervention. Fleas are bloodsucking parasites that are the major cause of skin disease in pets. Currently, all available flea products rely upon chemical control and many have active components that have real or perceived health problems. Given that insect growth regulators do not kill adult fleas and pet owners are interested in using alternatives to insecticides, there is a clear need for a complementary form of flea control. We describe the novel use of Proteomic technology to identify flea proteins that are "switched on" during feeding and are specifically located in the gut. This project will enable the development of a vaccine that is systemic, kills adult fleas, is long-lasting and residue-free.Read moreRead less
Determining the impact of protozoan pathogens and strongyle worms on prime lamb production. This research will benefit wool and prime lamb industries nation-wide as sheep scouring is prevalent in high-rainfall areas across Australia. Data generated from the project will be used to educate farmers and reduce the financial burden of sheep scouring. This project will also enhance Australia's reputation in the disease management sector and will result in reduced risk to public health due to a better ....Determining the impact of protozoan pathogens and strongyle worms on prime lamb production. This research will benefit wool and prime lamb industries nation-wide as sheep scouring is prevalent in high-rainfall areas across Australia. Data generated from the project will be used to educate farmers and reduce the financial burden of sheep scouring. This project will also enhance Australia's reputation in the disease management sector and will result in reduced risk to public health due to a better understanding and management of zoonotic parasite and microbacterial contamination of carcasses and water catchments.Read moreRead less
Understanding the molecular basis of virulence in Brachyspira hyodysenteriae to improve vaccine design. Swine dysentery is a colonic infection of pigs caused by Brachyspira hyodysenteriae. The disease is widespread in Australia and causes great economic loss. An effective vaccine is not available. This study aims to identify factors associated with the bacterium's virulence, using comparative genomic and proteomic information. Virulence factors then will be targeted and tested as recombinant vac ....Understanding the molecular basis of virulence in Brachyspira hyodysenteriae to improve vaccine design. Swine dysentery is a colonic infection of pigs caused by Brachyspira hyodysenteriae. The disease is widespread in Australia and causes great economic loss. An effective vaccine is not available. This study aims to identify factors associated with the bacterium's virulence, using comparative genomic and proteomic information. Virulence factors then will be targeted and tested as recombinant vaccine candidates. This project will result in the development of an improved vaccine to control swine dysentery in rural Australia. Control of swine dysentery through vaccination will reduce antibiotic use on infected farms and improve the productivity and competitiveness of the Australian pig industry.Read moreRead less
Genomic sequencing and comparative genomic analysis for animal bacterial vaccine discovery. The aim of this project is to develop vaccines for the control of swine dysentery (pigs) and intestinal spirochaetosis (pigs and chickens). These infections cause important production-limiting diseases for which no effective vaccines are available. We will use whole genomic sequencing of the two causal species of intestinal spirochaetal bacteria, with a bioinformatics-based analysis of the data to identif ....Genomic sequencing and comparative genomic analysis for animal bacterial vaccine discovery. The aim of this project is to develop vaccines for the control of swine dysentery (pigs) and intestinal spirochaetosis (pigs and chickens). These infections cause important production-limiting diseases for which no effective vaccines are available. We will use whole genomic sequencing of the two causal species of intestinal spirochaetal bacteria, with a bioinformatics-based analysis of the data to identify potential cell surface structures that will be tested as the basis of new recombinant vaccines. Outcomes will include the development of new commercial products, increased institutional capacity in veterinary vaccine discovery, and ultimately improved animal health and production in rural Australia.Read moreRead less
Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe t ....Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe that appears to have uniquely evolved in Australia. These results could inform the rational design of monitoring, prevention and treatment strategies to minimise infection outbreaks in Australian pigs and may result in production benefits to the pork industry, reduced environmental microbial contamination and safer food.Read moreRead less
Safeguarding Honeybees: Increasing parasite treatment effectiveness using nanotechnology. There is increasing concern about the exposure of honeybees to pesticides used to control both agricultural pests and diseases. Emerging reports indicate that these chemicals substantially harm bees and therefore contribute to the dramatic declines reported. A widespread bee pathogen, Nosema, will be used to directly quantify the effectiveness of commercially used pesticides on both parasite and honeybee vi ....Safeguarding Honeybees: Increasing parasite treatment effectiveness using nanotechnology. There is increasing concern about the exposure of honeybees to pesticides used to control both agricultural pests and diseases. Emerging reports indicate that these chemicals substantially harm bees and therefore contribute to the dramatic declines reported. A widespread bee pathogen, Nosema, will be used to directly quantify the effectiveness of commercially used pesticides on both parasite and honeybee viability. Furthermore, state-of-the-art nanotechnology will be used to develop benign treatments with enhanced effectiveness and minimal dosage/exposure to the bees. Outcomes of this project can have major impact on future parasite management in commercial honeybees.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100382
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Odorant recognition in insect olfactory system to control insect behaviour. This project seeks to develop new insights into insect’s ability to detect odour and to identify potential attractant compounds to support the development of environmentally safer insect pest control strategies. Insect reliance on senses to detect food has considerable potential for the development of odour-based behaviour control methods. Odorant binding proteins (OBPs) are an ideal molecular target to identify odorant- ....Odorant recognition in insect olfactory system to control insect behaviour. This project seeks to develop new insights into insect’s ability to detect odour and to identify potential attractant compounds to support the development of environmentally safer insect pest control strategies. Insect reliance on senses to detect food has considerable potential for the development of odour-based behaviour control methods. Odorant binding proteins (OBPs) are an ideal molecular target to identify odorant-based insect attractants from a large pool of compounds. However, our understanding of the molecular mechanism that mediates chemoreception in insects is limited. This project may provide valuable insight into the role of OBPs in molecular recognition in insects and develop a new way to screen attractants based on the binding ability of OBPs to compounds.Read moreRead less
Determination of factors responsible for aphid-borne pea seed-borne mosaic virus epidemics in peas and development of effective virus management tools. Aphid-borne virus epidemics threaten Australia’s $64 million per annum field pea industry. Factors affecting aphid survival within and outside growing seasons, time of first arrival in crops, and virus epidemic development will be identified. A forecasting model and Decision Support System will minimise the losses and permit industry expansion to ....Determination of factors responsible for aphid-borne pea seed-borne mosaic virus epidemics in peas and development of effective virus management tools. Aphid-borne virus epidemics threaten Australia’s $64 million per annum field pea industry. Factors affecting aphid survival within and outside growing seasons, time of first arrival in crops, and virus epidemic development will be identified. A forecasting model and Decision Support System will minimise the losses and permit industry expansion to new areas.Read moreRead less
Fungal Glucanase Genes for Engineering Disease Resistance in Plants. Plants can be engineered for resistance to fungal diseases by transformation with recombinant genes encoding chitinase or glucanase. Although fungi are prolific producers of glucanases, with some species producing novel forms, they have been unexplored as a source of useful glucanases. This project will isolate glucanase-producing fungi from soil, screen them for antifungal activity, and clone the glucanase genes from one or m ....Fungal Glucanase Genes for Engineering Disease Resistance in Plants. Plants can be engineered for resistance to fungal diseases by transformation with recombinant genes encoding chitinase or glucanase. Although fungi are prolific producers of glucanases, with some species producing novel forms, they have been unexplored as a source of useful glucanases. This project will isolate glucanase-producing fungi from soil, screen them for antifungal activity, and clone the glucanase genes from one or more isolates. In view of the high degree of biodiversity in WA soils, we have a high expectation of finding novel glucanases which will be useful for engineering disease resistance in plants, or for other industrial processes.Read moreRead less
Life hanging on a thread; disrupting the structure and function of lepidopteran silking behaviour. The production and use of silk by many invertebrates is vital for their survival. We develop a means of visualising and understanding the role of silking behaviour as a survival mechanism for Helicoverpa larvae (a key world-wide pest) with a view to disrupting silking. This novel project allows us to understand not just where larvae go but what they do along the way. The project outcomes will have ....Life hanging on a thread; disrupting the structure and function of lepidopteran silking behaviour. The production and use of silk by many invertebrates is vital for their survival. We develop a means of visualising and understanding the role of silking behaviour as a survival mechanism for Helicoverpa larvae (a key world-wide pest) with a view to disrupting silking. This novel project allows us to understand not just where larvae go but what they do along the way. The project outcomes will have wide application to the study and control of lepidopteran pests in natural and agricultural ecosystems and is of interest to applied and fundamental projects associated with insect pest control, behaviour and ecology.Read moreRead less