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How to make antibiotics in pig feed redundant, naturally. Antimicrobial resistance has become a major issue in human and veterinary medicine being partially caused by the use of in-feed antimicrobials in farm animals. This project aims to completely eliminate antimicrobials from piglet feeds. The key differential approach is based on helping the physiology of the animal rather than testing interventions against bacteria. The project will consist of developing a novel nutritional strategy of natu ....How to make antibiotics in pig feed redundant, naturally. Antimicrobial resistance has become a major issue in human and veterinary medicine being partially caused by the use of in-feed antimicrobials in farm animals. This project aims to completely eliminate antimicrobials from piglet feeds. The key differential approach is based on helping the physiology of the animal rather than testing interventions against bacteria. The project will consist of developing a novel nutritional strategy of naturally (through maternal conditioning) boosting the natural appetite and the capacity to digest in piglets early in life. The anticipated outcome is that the new peri-natal program will result in minimal bacterial proliferation and diarrhoea thus, negating the need for in-feed antimicrobials in piglets. Read moreRead less
Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an ....Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an animal health and production problem in the life of the commercial pig. This project will generate new knowledge on early life management to endow stress resilience in pigs, with expected benefits for animal welfare, farm productivity and profitability.Read moreRead less
Measuring pain in livestock: mechanisms, objective biomarkers and treatments. This project aims to create an objective blood test to measure pain in livestock, and to create a new drug treatment for persistent pain by targeting the immunology of the brain and spinal cord. This project expects to generate new knowledge of the involvement of the neuro-immune system in the creation and maintenance of persistent pain and how this can be quantified through the innovative use of peripheral blood tests ....Measuring pain in livestock: mechanisms, objective biomarkers and treatments. This project aims to create an objective blood test to measure pain in livestock, and to create a new drug treatment for persistent pain by targeting the immunology of the brain and spinal cord. This project expects to generate new knowledge of the involvement of the neuro-immune system in the creation and maintenance of persistent pain and how this can be quantified through the innovative use of peripheral blood tests. Expected outcomes of this project include a blood test capable of quantifying the extent of current pain experience, and a cumulative life measure of pain an animal has experienced. This should provide significant benefits to the Australian livestock industry by improving best practice.Read moreRead less
Early African woodworking and tool use at the transition to modern humans. Our archaeological excavations and preliminary dating of Amanzi Springs (South Africa) to between 515,000 and 163,000 years ago shows that the site covers a critical time period that led to the origins of our species, Homo sapiens. Amanzi documents, in never before seen resolution, the technological leaps that our ancestors made during this transition. At ~400,000 years ago this includes the oldest evidence for woodworkin ....Early African woodworking and tool use at the transition to modern humans. Our archaeological excavations and preliminary dating of Amanzi Springs (South Africa) to between 515,000 and 163,000 years ago shows that the site covers a critical time period that led to the origins of our species, Homo sapiens. Amanzi documents, in never before seen resolution, the technological leaps that our ancestors made during this transition. At ~400,000 years ago this includes the oldest evidence for woodworking and tool use and >163,000 years ago the oldest heat treatment of rock to make stone tools. The organic preservation at the site means that we can reconstruct changing environment, linked to sea level changes and spring activity, for this period in the evolution of our ancestors at a level of detail not previously possibleRead moreRead less
Artificial intelligence algorithms to predict risk of injury in racehorses. This project will address the urgent need for predicting and preventing catastrophic and career limiting limb injuries and cardiac arrhythmias in racehorses due to over (or under) training. Using data from GPS and movement sensors integrated into saddlecloths, artificial intelligence algorithms will convert cumulative data on speed, gait, and stride characteristics during training, along with injury data, into a risk mat ....Artificial intelligence algorithms to predict risk of injury in racehorses. This project will address the urgent need for predicting and preventing catastrophic and career limiting limb injuries and cardiac arrhythmias in racehorses due to over (or under) training. Using data from GPS and movement sensors integrated into saddlecloths, artificial intelligence algorithms will convert cumulative data on speed, gait, and stride characteristics during training, along with injury data, into a risk matrix. Recorded heart rate and ECG data will also be analysed using artificial intelligence to detect early evidence of the development of cardiac arrhythmias. The system will improve racehorse welfare, providing a simple interface to warn trainers when risk of injury becomes high, in order to prevent catastrophic breakdown.Read moreRead less
Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilit ....Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilities, and released for community use. These developments underpin future ocean state forecasts, sea ice forecasts, wave forecasts, decadal climate prediction and climate process studies. The project will benefit search and rescue, Defence and shipping operations, and will enhance future climate projections.Read moreRead less
Safeguarding coral reef fisheries for future food security. This Fellowship aims to address the vulnerability of coral reef fisheries in Australia and the Indo-Pacific by identifying fishery targets that benefit human nutrition and will persist despite declining coral habitats and rising water temperature. This project will advance knowledge on coral and fish responses to increasingly frequent marine heatwaves, using novel methodologies rooted in ecological modelling, experimental marine biology ....Safeguarding coral reef fisheries for future food security. This Fellowship aims to address the vulnerability of coral reef fisheries in Australia and the Indo-Pacific by identifying fishery targets that benefit human nutrition and will persist despite declining coral habitats and rising water temperature. This project will advance knowledge on coral and fish responses to increasingly frequent marine heatwaves, using novel methodologies rooted in ecological modelling, experimental marine biology and climate forecasting. Expected outcomes include (i) a comprehensive toolbox for improved management of coral reefs and associated fisheries in Australia and beyond, and (ii) an integrated socio-ecological model for predicting coral reef fishery responses under environmental change.Read moreRead less
Safer gene editing tools for Australian livestock and biotech industries. Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this the CI team created a novel genome editing platform technology termed Crackling-CAST that is almost 100% accurate, w ....Safer gene editing tools for Australian livestock and biotech industries. Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this the CI team created a novel genome editing platform technology termed Crackling-CAST that is almost 100% accurate, while retaining the efficiency of the classical Cas9 system. This project will exemplify the capabilities of the novel gene targeting platform in cell types used by the biotechnology and livestock sectors, ensuring its global uptake by these industries and delivering significant economic benefits for Australia. Read moreRead less
Utilising novel Pongamia trees to decarbonise Australia’s beef value-chain. Progress towards a carbon neutral beef industry typically focusses on nutritional strategies, overlooking potential innovations in farming system configuration. This project aims to develop a framework for the integration of Pongamia into beef production systems, so that not only emissions reductions are maximised, but also to support carbon capture and farm system resilience. This project seeks to determine the impact o ....Utilising novel Pongamia trees to decarbonise Australia’s beef value-chain. Progress towards a carbon neutral beef industry typically focusses on nutritional strategies, overlooking potential innovations in farming system configuration. This project aims to develop a framework for the integration of Pongamia into beef production systems, so that not only emissions reductions are maximised, but also to support carbon capture and farm system resilience. This project seeks to determine the impact of Pongamia meal on cattle production efficiency, meat quality and methane emissions. Through quantification of carbon sequestration potential in tree plantations, whole-farm modelling will elucidate production scenarios capable of achieving the reductions needed for a carbon neutral Australian beef industry.Read moreRead less
Early desert settlement of Arabia following out-of-Africa human dispersals. This project aims to improve our understanding of the nature, timing and climatic context of early human expansion into SW Asia, from a new extensive archaeological complex with associated palaeoenvironmental sequences on the Arabian Peninsula – a strategic out-of-Africa migratory corridor. It will combine innovative approaches in archaeology, geochronology and palaeoenvironmental research to evaluate the environmental a ....Early desert settlement of Arabia following out-of-Africa human dispersals. This project aims to improve our understanding of the nature, timing and climatic context of early human expansion into SW Asia, from a new extensive archaeological complex with associated palaeoenvironmental sequences on the Arabian Peninsula – a strategic out-of-Africa migratory corridor. It will combine innovative approaches in archaeology, geochronology and palaeoenvironmental research to evaluate the environmental and cultural adaptability of early desert settlement, providing critical new insights into globally significant human dispersal debates spanning multiple continents, including Australia. The aim is a fundamental new perspective on long-term human occupation dynamics of deserts and new understanding of regional dispersals.Read moreRead less