A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To un ....A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To understand how the method can be optimized, the thermodynamic pathway of membrane disruption will be investigated at a single cell level. The methods and insights arising from this project could eventually lead to novel, patentable and lower-cost health technologies.Read moreRead less
RoboCrab: An integrative approach to the natural ecology of decision making. The project aims to analyse and model the sophisticated and context-dependent escape behaviour of fiddler crabs under both natural conditions and in controlled laboratory settings. A crucial problem for biology is to understand how animals can make adaptive decisions in natural, complex sensory environments; such understanding also has direct application to robotics. The project plans to examine the effects of eye stabi ....RoboCrab: An integrative approach to the natural ecology of decision making. The project aims to analyse and model the sophisticated and context-dependent escape behaviour of fiddler crabs under both natural conditions and in controlled laboratory settings. A crucial problem for biology is to understand how animals can make adaptive decisions in natural, complex sensory environments; such understanding also has direct application to robotics. The project plans to examine the effects of eye stabilisation and oscillation, record from key neural stages using naturalistic stimuli to derive precise algorithms, and integrate and test the results on a robot model – RoboCrab. This may provide new insight into the integration of low-level sensory input with behavioural decision making circuits and the evolution of escape behaviours.Read moreRead less
Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to ....Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to utilise these findings to improve the control of neuronal excitability, for development of interfaces with the nervous system.Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
Paving the way to greener roads and healthier waterways. Waste tyre permeable pavement is emerging as an effective stormwater surge mitigation solution. Yet, its behaviour under traffic loads and varied environmental conditions are not fully understood which undermines industry confidence in this technology. This project aims to advance the engineering of waste tyre permeable pavements by creating new knowledge on their mechanical and hydrological performance. The project will develop design gui ....Paving the way to greener roads and healthier waterways. Waste tyre permeable pavement is emerging as an effective stormwater surge mitigation solution. Yet, its behaviour under traffic loads and varied environmental conditions are not fully understood which undermines industry confidence in this technology. This project aims to advance the engineering of waste tyre permeable pavements by creating new knowledge on their mechanical and hydrological performance. The project will develop design guidelines, identify the governing mechanisms and develop a performance prediction framework based on laboratory and field tests, and advanced numerical modelling. The mechanisms of performance from micro to macro level will be identified, generating knowledge for industry to support widespread uptake.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100108
Funder
Australian Research Council
Funding Amount
$325,650.00
Summary
Fundamental aspects of vertical and horizontal consolidation in a multi-layered soil system. Land reclamation is a multi-billion dollar industry that is most often carried out in coastal regions by reclaiming seabed foundations of marine clay using dredged waste. This project will develop an analytical framework for predicting the rate of settlements in the resulting multi-layer system which will incorporate a variety of factors known to directly influence the rate of consolidation. After valida ....Fundamental aspects of vertical and horizontal consolidation in a multi-layered soil system. Land reclamation is a multi-billion dollar industry that is most often carried out in coastal regions by reclaiming seabed foundations of marine clay using dredged waste. This project will develop an analytical framework for predicting the rate of settlements in the resulting multi-layer system which will incorporate a variety of factors known to directly influence the rate of consolidation. After validation using experimental data and numerical simulations, the proposed analytical model can be used to mimic soil behaviour more closely than traditional models, thereby leading to more realistic settlement predictions.Read moreRead less
A novel physical-digital approach for the assessing a large critical asset. This project aims to deliver an artificial intelligence-enabled decision-making tool to maintain and manage the floating covers of vast lagoons that treat raw sewage. The cover harvests the biogas released from the anaerobic digestion of sewage for electric power generation that exceeds the plant’s requirement. The approach involves an innovative thermographic technique and exploits transfer learning to adapt neural netw ....A novel physical-digital approach for the assessing a large critical asset. This project aims to deliver an artificial intelligence-enabled decision-making tool to maintain and manage the floating covers of vast lagoons that treat raw sewage. The cover harvests the biogas released from the anaerobic digestion of sewage for electric power generation that exceeds the plant’s requirement. The approach involves an innovative thermographic technique and exploits transfer learning to adapt neural networks trained on lab-scale and synthetic data to field implementation. The outcome is a machine learning framework to optimise biogas harvesting and renewable energy generation, and to avoid structural failure, that is capable of continuous improvement to take into account improved data and/or modelling capabilities.Read moreRead less
Liquefaction of silty soils: Micromechanics, modelling and prediction. The project aims to develop a numerical approach to understand liquefaction in silty soils. Liquefaction of silty soils in submarine landslides, mine tailings dam failures and cargo liquefaction in vessels carrying iron/nickel ores can cause property loss and be fatal. This project will bridge the behaviours across the scales and deliver constitutive models that possess grain scale mechanisms for better prediction of liquefac ....Liquefaction of silty soils: Micromechanics, modelling and prediction. The project aims to develop a numerical approach to understand liquefaction in silty soils. Liquefaction of silty soils in submarine landslides, mine tailings dam failures and cargo liquefaction in vessels carrying iron/nickel ores can cause property loss and be fatal. This project will bridge the behaviours across the scales and deliver constitutive models that possess grain scale mechanisms for better prediction of liquefaction induced failure at the large scales. The expected outcomes are liquefaction criteria for silty soils with different silt contents and numerical tools to predict the onset of liquefaction and flow of liquefied soils.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100042
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Virtual reality for planning of green urban water infrastructure. This project aims to research the planning-technical-social dynamics of Water Sensitive Urban Design (WSUD) infrastructure. WSUD management has become financially and logistically unsustainable due to major urban growth and a rapid uptake in WSUD assets. Solving this problem is, however, complex, as stakeholders have conflicting needs and tacit knowledge that is difficult to quantify. Using emerging virtual reality technology, par ....Virtual reality for planning of green urban water infrastructure. This project aims to research the planning-technical-social dynamics of Water Sensitive Urban Design (WSUD) infrastructure. WSUD management has become financially and logistically unsustainable due to major urban growth and a rapid uptake in WSUD assets. Solving this problem is, however, complex, as stakeholders have conflicting needs and tacit knowledge that is difficult to quantify. Using emerging virtual reality technology, participatory planning and operational models, this project intends to improve WSUD modelling science through integrated modelling. The anticipated outcome is more holistic and economically efficient planning of WSUD layouts in future cities. This is expected to address growing concerns about adequately managing these systems and ensure that they deliver intended environmental protection, liveability and public health benefits.Read moreRead less
Next-generation smart water network for performance-driven asset management. This project aims to develop smart water network systems and techniques for continuous monitoring and early detection of structural failure in water distribution systems. Water assets are critical infrastructure, and they consist of a network of buried pipes that are old and deteriorating, with an annual maintenance overhead exceeding $1billion per year in Australia. This project is expected to deliver next-generation s ....Next-generation smart water network for performance-driven asset management. This project aims to develop smart water network systems and techniques for continuous monitoring and early detection of structural failure in water distribution systems. Water assets are critical infrastructure, and they consist of a network of buried pipes that are old and deteriorating, with an annual maintenance overhead exceeding $1billion per year in Australia. This project is expected to deliver next-generation smart water technology that enables continuous assessment of the actual performance of water pipe networks, guide “just in time” pipe replacement and optimise operations. This technology will assist asset managers to make informed decisions, strategically prioritise investment and extend asset life.Read moreRead less