Neuregulin 1 Type III Overexpression And Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$651,966.00
Summary
Neuregulin (NRG1) is a neuronal growth factor and regulates the development of cortical inhibitory interneurons. Human studies suggest that NRG1 type III overexpression and deficient interneuron development underlie schizophrenia. Thus, we have developed a mouse overexpressing Nrg1 type III to discover mechanisms behind NRG1-related cortical pathology and schizophrenia-like behaviours and to clarify whether NRG1 type III interacts with environmental risk factors for the disorder.
Cannabidiol (CBD): A Novel Therapeutic For Alzheimer's Disease.
Funder
National Health and Medical Research Council
Funding Amount
$775,005.00
Summary
Current drugs do not stop or reverse the progression of Alzheimer’s disease (AD). Also, brains of AD patients show a number of biological changes and effective drugs should target those together. Cannabidiol (CBD) has such abilities when tested in AD cell models. We found that CBD can also prevent and reverse memory deficits in AD mice. We propose to provide convincing preclinical evidence for the benefits of CBD for human AD therapy and to define mechanisms involved.
Unraveling The Neural Circuitry Of Context-induced Relapse To Alcohol Seeking After Punishment-imposed Abstinence
Funder
National Health and Medical Research Council
Funding Amount
$528,016.00
Summary
Alcohol use disorder (alcoholism) causes significant social and economic costs to Australian society. Alcoholism is a brain disease, and relapse during abstinence is the main problem in successful treatment. In this project, we use an animal model of relapse to alcohol seeking after abstinence imposed by a negative consequence (punishment). This project will identify brain regions which can be targeted in future clinical studies in human alcoholics.
Orexin/Hypocretin Receptors In Self-Administration And Stress-Induced Reinstatement Of Ethanol Seeking
Funder
National Health and Medical Research Council
Funding Amount
$538,221.00
Summary
Orexin receptors are novel therapeutic targets implicated in alcohol use disorders. There is little known about how orexin receptors drive ethanol consumption and stress-induced reinstatement. This project provides a unique opportunity to determine the mechanism of action of orexin receptors in alcohol use disorders and devise novel therapeutic strategies to treat alcohol use disorders.
The Role Of Neuronal Nicotinic Receptor Subunits In The Self-Administration And Relapse To Alcohol Seeking:Treatments For Alcohol Dependence
Funder
National Health and Medical Research Council
Funding Amount
$531,787.00
Summary
The World Health Organization reports that alcohol causes almost two million deaths every year and results in physical disability or shortened life span for at least 58 million others. Despite the fact that addiction represents more than 40% of brain-related illnesses, there is a dearth of innovative treatments. The overall goal of my research is to develop more effective medications for the treatment of alcohol use disorder by targeting the neuronal nicotinic receptor subtypes that have been sp ....The World Health Organization reports that alcohol causes almost two million deaths every year and results in physical disability or shortened life span for at least 58 million others. Despite the fact that addiction represents more than 40% of brain-related illnesses, there is a dearth of innovative treatments. The overall goal of my research is to develop more effective medications for the treatment of alcohol use disorder by targeting the neuronal nicotinic receptor subtypes that have been specifically altered by heavy alcohol intake.Read moreRead less
Prevention Of Adverse Child Behavioural Development Following Maternal Depression In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$761,937.00
Summary
There is good evidence that if a woman is depressed while pregnant, her child is substantially more likely to have later emotional or behavioural problems. We will evaluate whether child outcomes following maternal depression in pregnancy can be improved by antenatal depression treatment. Our objective is to protect fetal and child development from the adverse developmental outcomes associated with untreated depression.
Promoting Responsible Drinking Practices To Drinkers To Reduce The Risk Of Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$271,476.00
Summary
Australians are heavy drinkers by world standards, which places them at risk of a wide range of alcohol-related harms. Broad-based interventions are needed to address a heavy drinking culture that involves regular engagement in heavy episodic drinking. This study will use a multi-method approach to develop and test messages that can be used to encourage enactment of responsible drinking practices that can reduce total alcohol intake and discourage binge drinking consumption patterns.
Mobile Intervention For Drinking In Young People (MIDY): Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$403,378.00
Summary
Binge drinking is a significant health and social issue in Australia. In this innovative trial, we will communicate with young people via their mobile phones while they are on a night out. Young people will send hourly information about their drinking and will receive a relevant message in response, encouraging them to slow down or avoid harmful activities. The methods and the messages were developed in partnership with young people and have been tested in real drinking situations.
Early Development, MicroRNAs, Dendritogenesis And Cognition
Funder
National Health and Medical Research Council
Funding Amount
$313,557.00
Summary
Neurodevelopmental disorders are characterised by a marked disruption of learning and memory, which is reflected by structural changes in the brains of affected individuals. However, little is known about the underlying mechanisms of this pathology or whether it is directly related to cognitive deficits across the lifespan. How the brain is wired during early development and its relationship to learning and memory in adulthood will therefore be determined.
Context Is Everything – Understanding How Spatial, Temporal And Behavioural Context Affect Sensory Processing
Funder
National Health and Medical Research Council
Funding Amount
$512,382.00
Summary
A possum in a tree is cute to see on a bushwalk, but scary to hear when we are trying to sleep. This illustrates that how we perceive a “target” is affected by “modulators” that are close in space or time to the target, or by the task at hand. Deficits in contextual modulation are apparent in many neurological conditions. This project will investigate the neural circuitry that mediates spatial, temporal and task-related contextual modulation.