Gastrointestinal hormones: linking insulin dysregulation and laminitis. This project aims to identify the earliest pathogenic factors of disease by investigating two key hormones, ghrelin and GLP-2, and whether a specific genetic mutation underlies insulin dysregulation. Using innovative approaches the project will enable the identification of at-risk animals and pinpoint novel treatment strategies. In the long term improved disease treatment and prevention will reduce the suffering associated w ....Gastrointestinal hormones: linking insulin dysregulation and laminitis. This project aims to identify the earliest pathogenic factors of disease by investigating two key hormones, ghrelin and GLP-2, and whether a specific genetic mutation underlies insulin dysregulation. Using innovative approaches the project will enable the identification of at-risk animals and pinpoint novel treatment strategies. In the long term improved disease treatment and prevention will reduce the suffering associated with painful and often lethal co-morbidities.Read moreRead less
How brains become lateralised. This project aims to understand how the left and right sides of the brain become specialised for different cognitive functions, a phenomenon called lateralisation. Lateralisation is one of the least understood organisational principles of the brain, yet is crucial to the way we think and behave. Manifested most clearly as handedness, the brain is lateralised for many cognitive tasks such as language, reasoning, memory and emotion. However, the developmental origin ....How brains become lateralised. This project aims to understand how the left and right sides of the brain become specialised for different cognitive functions, a phenomenon called lateralisation. Lateralisation is one of the least understood organisational principles of the brain, yet is crucial to the way we think and behave. Manifested most clearly as handedness, the brain is lateralised for many cognitive tasks such as language, reasoning, memory and emotion. However, the developmental origin and anatomical substrate of most cognitive asymmetries are unknown. This project will use a chick model of brain lateralisation to quantify and localise to specific brain circuits the patterns of differential gene expression that give rise to anatomical and functional asymmetries.Read moreRead less
Bacterial and host drivers of chlamydial blindness in koalas. Chlamydial infection of the eyes is a significant cause of disease and death in koalas, contributing to the ongoing decline of this native species. Little is known about what influences the outcome of these infections, challenging efforts to manage and control koala chlamydial blindness. This project aims to evaluate whether differences in the infecting Chlamydia pecorum strains or the koala immune response, are associated with the ou ....Bacterial and host drivers of chlamydial blindness in koalas. Chlamydial infection of the eyes is a significant cause of disease and death in koalas, contributing to the ongoing decline of this native species. Little is known about what influences the outcome of these infections, challenging efforts to manage and control koala chlamydial blindness. This project aims to evaluate whether differences in the infecting Chlamydia pecorum strains or the koala immune response, are associated with the outcome of chlamydial ocular infection. In addition to helping us to understand and prevent blindness in koalas, this project should significantly expand our knowledge of the koala immune system and generate an array of koala immunological assays, outcomes that may benefit all koala conservation efforts.Read moreRead less
Defining the molecular basis for Salmonella persistence. Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We ....Defining the molecular basis for Salmonella persistence. Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We identified several Salmonella specific genes and subsequent murine studies revealed that a Salmonella mutant lacking these genes is attenuated in mice and especially in the gallbladder. In this project we seek to understand the molecular basis for attenuation and the contribution of each protein to diseaseRead moreRead less
Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide ....Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.
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Finding the pathways to crime prevention for socially disadvantaged communities: theory, evidence and practice. Long-term scientific evaluations of interventions that 'get in early' before crime problems emerge or become entrenched have consistently shown that such approaches work. However, governments and community agencies struggle to use this evidence to mount effective programs in areas of concentrated disadvantage because the evidence comes in the form of 'program packages' rather than mode ....Finding the pathways to crime prevention for socially disadvantaged communities: theory, evidence and practice. Long-term scientific evaluations of interventions that 'get in early' before crime problems emerge or become entrenched have consistently shown that such approaches work. However, governments and community agencies struggle to use this evidence to mount effective programs in areas of concentrated disadvantage because the evidence comes in the form of 'program packages' rather than models of practice that take account of local contexts and the challenges involved in achieving effective and sustainable engagement with local people and institutions. This project will show how models of effective crime prevention practice for disadvantaged communities can be developed, tested and implemented on a large scale in an economically efficient way.Read moreRead less
Information and market design: mediation and analogical argumentation. This project aims to increase knowledge of how judicious disclosure of information facilitates economic exchange and social interactions and to shed light on how mediation can be an effective mode of dispute resolution. The project seeks to uncover how analogical arguments can be persuasive and determine social outcomes as well as provide guidance for advocates and decision makers on the best way to persuade and counteract mi ....Information and market design: mediation and analogical argumentation. This project aims to increase knowledge of how judicious disclosure of information facilitates economic exchange and social interactions and to shed light on how mediation can be an effective mode of dispute resolution. The project seeks to uncover how analogical arguments can be persuasive and determine social outcomes as well as provide guidance for advocates and decision makers on the best way to persuade and counteract misleading persuasion practices. Besides producing significant new knowledge, the project promises to inform future innovative economic, social and cultural developments of benefit to the Australian and international community.Read moreRead less
Cerebellar control of classical conditioning. This project proposes to use zebrafish, in combination with optogenetics, to identify and test patterns of neural activity that are responsible for classical conditioning. It will do this by describing the connections between the cerebellum and other brain regions, and by observing patterns of neural activity as learning takes place. Next, the project will block or recreate these patterns of activity to see whether they are necessary or sufficient fo ....Cerebellar control of classical conditioning. This project proposes to use zebrafish, in combination with optogenetics, to identify and test patterns of neural activity that are responsible for classical conditioning. It will do this by describing the connections between the cerebellum and other brain regions, and by observing patterns of neural activity as learning takes place. Next, the project will block or recreate these patterns of activity to see whether they are necessary or sufficient for learning. The goal is to describe, in concrete terms, how patterns of neural activity in this part of the brain result in learning. In so doing, the project also aims to develop and test new technologies and approaches for studying the functioning brain.Read moreRead less
Cerebellar control of motor coordination and learning. The cerebellum is the part of the brain responsible for smooth body movements, but many details of how it works are still unclear. This project is aimed at learning how the cerebellum communicates with the rest of the brain, and what parts of this communication are necessary for coordinated movement.
Peer Rejection and the Maladaptive Social Behaviour of Children and Adolescents. Research indicates that peer rejection has serious negative effects on child and adolescent victims. However, little research has addressed the likelihood that peer rejection also has negative consequences for others in the social environment, through its instigation of maladaptive social behaviours such as bullying and ethnic prejudice. Given the incidence of the latter behaviours in primary and secondary schools, ....Peer Rejection and the Maladaptive Social Behaviour of Children and Adolescents. Research indicates that peer rejection has serious negative effects on child and adolescent victims. However, little research has addressed the likelihood that peer rejection also has negative consequences for others in the social environment, through its instigation of maladaptive social behaviours such as bullying and ethnic prejudice. Given the incidence of the latter behaviours in primary and secondary schools, the aim of this project is to conduct a program of research to test an integrative model of the impact of peer rejection on the maladaptive social behaviours of children and adolescents, with a particular focus on ethnic prejudice and bullying.Read moreRead less