Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals. The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These c ....Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals. The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These cells cannot divide and so when this store is exhausted, reproduction ceases. Our strategy is to develop pharmaceutical reagents that will destroy this dormant egg population, thereby rendering the animals instantaneously and irreversibly infertile.Read moreRead less
Deterioration of structural integrity of ageing ships and marine platforms. Deterioration of structural integrity of ageing ships and marine platforms. This project will research the deterioration of structural integrity and remaining life of marine assets such as ships and offshore energy facilities, by integrating structural response analysis methods with aged-structure assessment techniques. Maritime assets exposed to ocean conditions suffer from time dependent phenomena, which reduce structu ....Deterioration of structural integrity of ageing ships and marine platforms. Deterioration of structural integrity of ageing ships and marine platforms. This project will research the deterioration of structural integrity and remaining life of marine assets such as ships and offshore energy facilities, by integrating structural response analysis methods with aged-structure assessment techniques. Maritime assets exposed to ocean conditions suffer from time dependent phenomena, which reduce structural capability, affect safety and could have catastrophic environmental and economic consequences. Making assets available and affordably safe is a problem for operators. The key to prolonging asset life is in understanding the interrelationships over time between the asset’s structural condition and its use. Anticipated outcomes are superior safety, expected lifetime and economic benefits of maritime assets.Read moreRead less
Ship response under corrosion, fatigue and complex sea-state environments. This project will improve understanding of the gradual deterioration of ships and maritime structures subject to metal corrosion, fatigue and extreme sea-state conditions. Increasingly such understanding is necessary for optimal asset management decisions. These include the potential economic, personnel and other risks involved for ship owners and operators, including the Royal Australian Navy (RAN). The project will use ....Ship response under corrosion, fatigue and complex sea-state environments. This project will improve understanding of the gradual deterioration of ships and maritime structures subject to metal corrosion, fatigue and extreme sea-state conditions. Increasingly such understanding is necessary for optimal asset management decisions. These include the potential economic, personnel and other risks involved for ship owners and operators, including the Royal Australian Navy (RAN). The project will use numerical simulation. It will tackle the Fluid-Structure Interaction problem of ships in waves by integrating Finite Element structural response analysis with cutting-edge Smoothed Particle Hydrodynamics methods. The outcomes will provide new insight into remaining asset life and for exploring optimal maintenance strategiesRead moreRead less
Regulating Autologous Stem Cell Therapies in Australia. This project aims to develop an ethical and regulatory framework for the use of autologous adult stem cell therapies in Australia. These therapies are increasingly being offered to patients for diseases and conditions that lack scientific evidence of safety and efficacy. This study aims to address this problem using a mixed methods approach to generate empirical data and theoretical, ethical and legal insights that will guide the responsibl ....Regulating Autologous Stem Cell Therapies in Australia. This project aims to develop an ethical and regulatory framework for the use of autologous adult stem cell therapies in Australia. These therapies are increasingly being offered to patients for diseases and conditions that lack scientific evidence of safety and efficacy. This study aims to address this problem using a mixed methods approach to generate empirical data and theoretical, ethical and legal insights that will guide the responsible development, translation and regulation of innovative stem cell therapies in Australia and internationally. Anticipated outcomes will improve patient advocacy and public knowledge about adult stem cell therapies, and facilitate better relationships between patients, researchers and clinicians.Read moreRead less
Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spri ....Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spring-like function of the foot. It will explain a conceptually novel design allowing shoes to support our feet, whilst harnessing the energetic benefits of the foot's spring-like function. This research has the potential to revolutionise athletic footwear design and has direct implications for enhanced performance in running athletes.Read moreRead less
Extinction of turtles in the River Murray: Consequences and Solutions. Turtles are a major ecological component of the Murray-Darling, Australia’s major river system. They are declining alarmingly with potential dire consequences for water quality, biodiversity, and river health. This project unites a world-class research team with diverse industry partners, indigenous groups, and non-government organisations from three states to address a problem of national significance. This project aims to i ....Extinction of turtles in the River Murray: Consequences and Solutions. Turtles are a major ecological component of the Murray-Darling, Australia’s major river system. They are declining alarmingly with potential dire consequences for water quality, biodiversity, and river health. This project unites a world-class research team with diverse industry partners, indigenous groups, and non-government organisations from three states to address a problem of national significance. This project aims to identify and quantify causes of declines in turtles along the whole system, with the aim of developing practical management options to overcome it. This will be the first river-wide study of turtles, achieved by combining cutting-edge genetic and ecological techniques with a citizen science program.Read moreRead less
Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The in ....Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The intended outcome will be a set of sensitive and analytical methods using a range of newly identified conjugated steroid markers and associated reference materials, which promises to enhance integrity and animal welfare in the thoroughbred racing industry.
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The molecular basis for oocyst and cyst wall formation in apicomplexan parasites. Apicomplexan parasites such as Eimeria, Neospora, Toxoplasma and Plasmodium are single celled organisms - protozoa - that cause some of the most serious infectious diseases of livestock and humans ever known. Transmission of these parasites is dependent on their ability to encase themselves in protective structures known as oocyst or cyst walls. These walls are resistant to harsh environmental conditions, chemicals ....The molecular basis for oocyst and cyst wall formation in apicomplexan parasites. Apicomplexan parasites such as Eimeria, Neospora, Toxoplasma and Plasmodium are single celled organisms - protozoa - that cause some of the most serious infectious diseases of livestock and humans ever known. Transmission of these parasites is dependent on their ability to encase themselves in protective structures known as oocyst or cyst walls. These walls are resistant to harsh environmental conditions, chemicals and attack by the immune system. We will discover and characterise the molecular basis for cyst wall formation. This fundamental knowledge will be the building block for new, highly specific drugs and vaccines to control these extremely important pathogens.Read moreRead less
Impacts of locust control pesticides on arid-zone fauna. Impacts of locust control pesticides on arid-zone fauna. This project aims to understand how different animals encounter pesticide in the landscape through quantifying residue deposition in arid grasslands and investigating how pesticides used to control locust plagues affect fauna. This project will investigate fenitrothion and fipronil, the main pesticides used in Australia for locust control. It will develop a deposition model for aeria ....Impacts of locust control pesticides on arid-zone fauna. Impacts of locust control pesticides on arid-zone fauna. This project aims to understand how different animals encounter pesticide in the landscape through quantifying residue deposition in arid grasslands and investigating how pesticides used to control locust plagues affect fauna. This project will investigate fenitrothion and fipronil, the main pesticides used in Australia for locust control. It will develop a deposition model for aerial pesticide spraying, determine the short-term effect of sprayed pesticides on the behaviour and condition of free-ranging target fauna that use the environment differently, and quantify the relative importance of dietary and non-dietary exposure routes to gauge the importance of animal behaviour on pesticide exposure. Anticipated outcomes are improved baseline assessments for locusticides.Read moreRead less
Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The ser ....Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The serological tests to be developed aim to be species-specific tests to detect the most important chlamydial sheep pathogens. This in turn endeavours to improve domestic surveillance, reducing on-farm losses and costs, and improve market opportunities for Australian sheep exporters as well as informing veterinary populations on best practice treatment.Read moreRead less