Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpt ....Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpts the output of individual neurones. The experiments will be extended to the study of possible interactions between different areas of the brain and the study of mechanisms by which the cortical network and higher cognitive factors such as attention and memory might influence the coding of sensory information in awake animals.Read moreRead less
The role of early life history on the survival of coral reef fishes - opening the Black Box. A fundamental unanswered question in marine ecology and fisheries management is - what influences the number of individuals that survive the larval phase to join a reef population? Theoretical studies show that small changes in the quality of offspring can lead to large changes in the numbers surviving the larval phase. What aspects of offspring quality determine who survives is largely unknown. We use ....The role of early life history on the survival of coral reef fishes - opening the Black Box. A fundamental unanswered question in marine ecology and fisheries management is - what influences the number of individuals that survive the larval phase to join a reef population? Theoretical studies show that small changes in the quality of offspring can lead to large changes in the numbers surviving the larval phase. What aspects of offspring quality determine who survives is largely unknown. We use a multidisciplinary approach to explore what influences the quality of offspring spawned by adults, and whether offspring traits prior to or at hatching determine the identity of individuals that survive to join the reproductive population.Read moreRead less
Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four ne ....Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four neuronal cell cultures established with gene-based selection criteria. These cultures will be characterised by gene expression, immunocytochemistry, radiolabelled neurotransmitter release, electrophysiology and Ca2+ imaging studies. This study will highlight the functional effects of gene selection procedures upon stem cell-derived neurons.Read moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
Deep Downunder: designing a deep-sea exploration and discovery capability for Australia. Exploration of the deep-sea with the modern technologies to be developed by Deep-Downunder is a first for Australia. We aim to explore and discover life at depths from 50-3000m off The Great Barrier Reef, around the seamounts of Lord Howe Island and Tasmania and in the deep canyons of WA and SA. We expect to discover new species, hope for a glimpse of giant squid at home and will answer specific questions on ....Deep Downunder: designing a deep-sea exploration and discovery capability for Australia. Exploration of the deep-sea with the modern technologies to be developed by Deep-Downunder is a first for Australia. We aim to explore and discover life at depths from 50-3000m off The Great Barrier Reef, around the seamounts of Lord Howe Island and Tasmania and in the deep canyons of WA and SA. We expect to discover new species, hope for a glimpse of giant squid at home and will answer specific questions on Australia's ocean biology, fisheries and biotechnology never before approachable. To be effective guardians of Australian waters we must learn what lies in the depths we can't see from a boat.Read moreRead less
Intelligent Biomedical System Modelling and Multi-modality Image Analysis to Maximize Diagnostic Information from Medical Imaging. Medical imaging is an essential part of our Australian modern health care system and plays an important role in the diagnosis, treatment planning and decision making and assessment of treatment of patients. This project aims to maximize the benefit of federal government healthcare investment through intelligent biomedical system modelling in conjunction with multi-mo ....Intelligent Biomedical System Modelling and Multi-modality Image Analysis to Maximize Diagnostic Information from Medical Imaging. Medical imaging is an essential part of our Australian modern health care system and plays an important role in the diagnosis, treatment planning and decision making and assessment of treatment of patients. This project aims to maximize the benefit of federal government healthcare investment through intelligent biomedical system modelling in conjunction with multi-modality image analysis to extract crucial additional information for accurate diagnosis and improved treatment, which will not only lead to a major scientific advancement, but also deliver significant social benefits.Read moreRead less
Designing an Intelligent Process Operation Management System. The complexity and sophistication of current generation of industrial processes, and the growing need for autonomous agents that control physical systems, motivate the need for the development of an intelligent process operation management system. In this project, the innovative integration of theories from different scientific fields (computer systems, process engineering, systems and control engineering) provides an excellent platfo ....Designing an Intelligent Process Operation Management System. The complexity and sophistication of current generation of industrial processes, and the growing need for autonomous agents that control physical systems, motivate the need for the development of an intelligent process operation management system. In this project, the innovative integration of theories from different scientific fields (computer systems, process engineering, systems and control engineering) provides an excellent platform for development of a smart data management tool, to oversee the major operational tasks within the plant and help the operators and engineers to make more informed decisions. Direct application of the techniques developed in this study to a pilot case study, could be used as a benchmark to show the potential benefits that can be gained through smart information use and data management.Read moreRead less
Effects of global climate change on marine phytoplankton: interactions between UV radiation and elevated atmospheric carbon dioxide levels. Global climate change is one of the most significant ecological challenges for the 21st Century. Phytoplankton contribute over 45% of the planet's annual net primary production and form the basis of most aquatic food chains. Conversely, some phytoplankton are toxic and cause problems in marine and fresh waters. Climate change can potentially disrupt aquatic ....Effects of global climate change on marine phytoplankton: interactions between UV radiation and elevated atmospheric carbon dioxide levels. Global climate change is one of the most significant ecological challenges for the 21st Century. Phytoplankton contribute over 45% of the planet's annual net primary production and form the basis of most aquatic food chains. Conversely, some phytoplankton are toxic and cause problems in marine and fresh waters. Climate change can potentially disrupt aquatic foodchains by its impact on primary production by phytoplankton or stimulating growth of potentially toxic forms. Our project will investigate the combined impact of increasing carbon dioxide and ultraviolet light on phytoplankton and thereby help climate modellers assess the impact of climate change on aquatic ecosystems and particularly on the nation's and the world's fisheries.Read moreRead less
Uncertain Information Processing for Situation Awareness and Dynamic Decision-Making in Emergency Management. The Australian national counter-terrorism committee indicates that Australia should have a strong intelligence-led prevention and preparedness to support Australia on risk management, emergency services and maintaining capabilities to manage various types of terrorist attacks. The proposed situation awareness support technique can be used to develop situation analysis software systems or ....Uncertain Information Processing for Situation Awareness and Dynamic Decision-Making in Emergency Management. The Australian national counter-terrorism committee indicates that Australia should have a strong intelligence-led prevention and preparedness to support Australia on risk management, emergency services and maintaining capabilities to manage various types of terrorist attacks. The proposed situation awareness support technique can be used to develop situation analysis software systems or directly support Australia government agencies and industries to correctly assess a situation, increase awareness for crisis problems, and therefore improve emergency management and decision-making effectiveness, in particular, for avoiding disaster problems in the first place and preparing plans for those that undoubtedly will occur. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989859
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistr ....A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistry, research supported by this instrumentation will provide Australians with improvements to their dental health. Furthermore applications to industrial materials are providing Australian industries with better characterisation of their products that is leading to improved export performance and consequent improvement in Australia's balance of trade.Read moreRead less