Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989782
Funder
Australian Research Council
Funding Amount
$524,000.00
Summary
A Core Western Australian Cell Sorting Facility - Ultra-Small Objects and Rare Cell Populations. This new generic capacity to rapidly isolate structures smaller than the cell has extraordinarily wide application in the biological sciences. Making this capacity widely accessible through a core facility to the Western Australian research community will generate research outcomes of national and community benefit. Sorting chromosomes to better understand genetic abnormalities and sorting bacteria t ....A Core Western Australian Cell Sorting Facility - Ultra-Small Objects and Rare Cell Populations. This new generic capacity to rapidly isolate structures smaller than the cell has extraordinarily wide application in the biological sciences. Making this capacity widely accessible through a core facility to the Western Australian research community will generate research outcomes of national and community benefit. Sorting chromosomes to better understand genetic abnormalities and sorting bacteria to better understand and reduce bacterial infection will result in improvements in human health. Sorting parasites, bacteria and immune cells will lead to new animal vaccines for parasites and diseases such as bird flu. Sorting marine plankton will lead to more sustainable marine ecosystems and fisheries.Read moreRead less
Preparation of Photo-Affinity Molecular Probes for the Identification of Gibberellin Receptors. Bioactive gibberellins affect numerous processes during plant growth and development, including seed germination, leaf expansion, stem elongation, flowering and fruit development. However, only very limited information is available regarding their mode of action at the molecular level. The central aim of the project is to prepare a family of photo-affinity molecular probes based on the gibberellin m ....Preparation of Photo-Affinity Molecular Probes for the Identification of Gibberellin Receptors. Bioactive gibberellins affect numerous processes during plant growth and development, including seed germination, leaf expansion, stem elongation, flowering and fruit development. However, only very limited information is available regarding their mode of action at the molecular level. The central aim of the project is to prepare a family of photo-affinity molecular probes based on the gibberellin molecule that will be designed to provide critical information on the location and structure of gibberellin receptors. Screening of the probes for potential effectiveness will be determined initially by the measurement of alpha-amylase produced in a standard barley aleurone assay.Read moreRead less
Discovery of novel circular proteins in bacteria, plants and animals: applications in drug design and crop protection. The overall goal is to use innovative methods in chemistry, biochemistry and molecular biology to determine the structures and functions of several families of circular proteins that have exciting pharmaceutical and agricultural applications. These molecules differ from conventional proteins in that they have no ends: their termini are seamlessly joined, thereby making them exce ....Discovery of novel circular proteins in bacteria, plants and animals: applications in drug design and crop protection. The overall goal is to use innovative methods in chemistry, biochemistry and molecular biology to determine the structures and functions of several families of circular proteins that have exciting pharmaceutical and agricultural applications. These molecules differ from conventional proteins in that they have no ends: their termini are seamlessly joined, thereby making them exceptionally stable and resistant to enzyme digestion. The big question is ?How and why does Nature produce circular proteins?" Increasing our knowledge of why circular proteins have evolved will facilitate their applications in drug design and in the development of novel insecticides.Read moreRead less
Membrane transporters in oxidative stress signalling and tolerance in plants. Oxidative stress imposed by salinity and drought severely limits agricultural crop production, resulting in multibillion dollar losses to farmers. Australia is one of the driest continents, with a significant proportion of arable land affected by salinity. Thus, developing salt- and drought tolerant species is critical to minimise the impact of these stresses on crop production. This project will reveal specific ionic ....Membrane transporters in oxidative stress signalling and tolerance in plants. Oxidative stress imposed by salinity and drought severely limits agricultural crop production, resulting in multibillion dollar losses to farmers. Australia is one of the driest continents, with a significant proportion of arable land affected by salinity. Thus, developing salt- and drought tolerant species is critical to minimise the impact of these stresses on crop production. This project will reveal specific ionic mechanisms mediating reactive oxygen species signalling and tolerance in plants. This will help achieve the above goal by providing plant breeders with vital information on key genes controlling oxidative stress tolerance in plants. Read moreRead less
Coping with flooding: nutrient transport in oxygen-deprived roots. Flooding damages plants by reducing oxygen supply to roots. The project will study effects of low oxygen on nutrient transport by roots. Understanding root functioning during low oxygen will enhance knowledge of plant acclimation to soil water logging. The project will contribute to the National Goal of 'Responding to Climate Change and Variability'.
Is water deficit the predisposing factor associated with Agonis flexuosa (WA peppermint) decline in Western Australia? The incidence and severity of tree decline across species is now widespread in southern Western Australia. There is increasing concern about their management by agencies, landowners and the community, due to the loss of aesthetics, biodiversity and ecosystem services. This project will provide remote sensing tools to monitor peppermint health and relate declines to abiotic and b ....Is water deficit the predisposing factor associated with Agonis flexuosa (WA peppermint) decline in Western Australia? The incidence and severity of tree decline across species is now widespread in southern Western Australia. There is increasing concern about their management by agencies, landowners and the community, due to the loss of aesthetics, biodiversity and ecosystem services. This project will provide remote sensing tools to monitor peppermint health and relate declines to abiotic and biotic factors. An understanding of how water abstraction for urban development and declining rainfall predispose trees to decline, and the application of thinning regimes, fungicides and nutrient implants will provide potential tools to the wider community that can be used to manage tree health.Read moreRead less
Diversity of pollination biology in heat-producing flowers. This research is an entirely new approach to understanding pollination biology. It will highlight the value of ecological diversity in tropical ecosystems and will work toward conservation of these threatened habitats. The project is very strong in developing international links, involving Australia, Germany, France, Turkey, Brazil, Guyana, India and Malaysia. By supporting research involving the International Canopy Crane Network, A ....Diversity of pollination biology in heat-producing flowers. This research is an entirely new approach to understanding pollination biology. It will highlight the value of ecological diversity in tropical ecosystems and will work toward conservation of these threatened habitats. The project is very strong in developing international links, involving Australia, Germany, France, Turkey, Brazil, Guyana, India and Malaysia. By supporting research involving the International Canopy Crane Network, Australia will be recognised as a major contributor to the multinational effort. The project deals with energetics of scarab beetles, with work on reproductive energetics of natural and pest species. Research maintains and develops critical thought, essential for effective university teaching and training.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101096
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Evolutionary Adaptation of the Chemical Language of Nutrient Acquisition Strategies in Higher Plants. The autotrophic and sessile nature of plants means that they need to respond to nutrient limitations in a finely tuned manner to grow and survive. Metabolites play an important role during these adaptations, either as direct modulators or as biochemical indicators of the pathways activated. Plants have evolved from relatively simple unicellular organisms that have a remarkable adaptability to re ....Evolutionary Adaptation of the Chemical Language of Nutrient Acquisition Strategies in Higher Plants. The autotrophic and sessile nature of plants means that they need to respond to nutrient limitations in a finely tuned manner to grow and survive. Metabolites play an important role during these adaptations, either as direct modulators or as biochemical indicators of the pathways activated. Plants have evolved from relatively simple unicellular organisms that have a remarkable adaptability to respond to their environment through metabolite-modulated quorum-sensing mechanisms. Preliminary evidence suggests that plants have either retained some of this ability or have evolved novel nutrient recognition strategies. This project will elucidate these pathways to gain new insights into nutrient acquisition in plants.Read moreRead less
More than defence: primary roles for cyanogenic glucosides. The tropical crop, sorghum, produces toxic cyanide to avoid being eaten by herbivores, but this diverts resources away from growth and reproduction. Using non-toxic sorghum mutants, this project seeks to explain how cyanide production is regulated and enhance agricultural efficiency in the face of climate change.