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Preventing The Transition From Acute To Chronic Pain. The Role Of Neural And Non-neural Factors.
Funder
National Health and Medical Research Council
Funding Amount
$2,998,900.00
Summary
Pain following injury usually dissipates as the injury heals, however in some individuals it persists and lasts for years. Chronic pain is extremely difficult to treat, particularly that which originates from a damaged nerve. One of the roadblocks in developing effective treatments is our limited understanding of the pathophysiology. The overall aim of this proposal is to address this gap and determine the processes that occur in the brain that results in acute pain transitioning to chronic.
Understanding Sex Differences In Alcohol Use Disorder: The Role Of Stress And Neuropeptides
Funder
National Health and Medical Research Council
Funding Amount
$692,106.00
Summary
Alcohol use disorders (AUD) are an emerging issue in women, yet there is little understanding of the how the male and female brains differ in response to excessive alcohol consumption. In pilot studies, we have found that deletion of a specific brain chemical causes differences in the way male and female mice consume alcohol in excess. We will further characterise this system and test new approaches to reduce the desire to consume alcohol.
Should You Be Eating That? Food-derived Bacteria And Their Role In Treating Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,405,182.00
Summary
The clinical application of medicines based on the microbes that exist as part of microbiomes is now a reality. Despite these rapid advances understanding how the bacteria are transmitted and recolonise after disruption is essential. Our preliminary data suggests that the average Australian adult consumes over 10 million bacteria per day in their diet. This project seeks to understand these relationships and how they can be exploited to develop the next generations of microbiome based medicine.