Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine m ....Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine mammals. This study will significantly advance our knowledge of the diving physiology of Australian marine mammals. A detailed examination of the respiratory and surfactant systems of marine mammals may also reveal adaptations that enable these animals to endure sleep apnea and lung collapse.Read moreRead less
FERTILIZATION IN VIVO AND IN VITRO IN AUSTRALIAN MARSUPIALS. Using reproductive technology previously undeveloped in Australian marsupials this study addresses the most significant question still unresolved in marsupial reproductive biology - 'How does fertilization occur?' We propose to investigate the morphological and functional characteristics of fertilisation and its roles in early development in marsupials, the uniqueness of these events and their evolutionary significance. These findings ....FERTILIZATION IN VIVO AND IN VITRO IN AUSTRALIAN MARSUPIALS. Using reproductive technology previously undeveloped in Australian marsupials this study addresses the most significant question still unresolved in marsupial reproductive biology - 'How does fertilization occur?' We propose to investigate the morphological and functional characteristics of fertilisation and its roles in early development in marsupials, the uniqueness of these events and their evolutionary significance. These findings will not only further our knowledge of reproduction in marsupials and shed light on the evolutionary factors underlying sperm and egg design but will provide tools for assisted breeding programs for threatened wildlife and for the regulation of over abundant species.Read moreRead less
The comparative physiology of oxygen delivery to the kidney. The kidney is in danger of hyperoxia because the kidney receives so much blood relative to its mass. It is proposed that shunting oxygen between arteries and veins substantially mitigates the risk of hyperoxia, but under certain circumstances shunting substantially increases the risk of kidney hypoxia. Using a combination of synchrotron and histological imaging, This project will carefully define the three-dimensional vasculature of th ....The comparative physiology of oxygen delivery to the kidney. The kidney is in danger of hyperoxia because the kidney receives so much blood relative to its mass. It is proposed that shunting oxygen between arteries and veins substantially mitigates the risk of hyperoxia, but under certain circumstances shunting substantially increases the risk of kidney hypoxia. Using a combination of synchrotron and histological imaging, This project will carefully define the three-dimensional vasculature of the renal cortex in several different species and interpret its functional significance using computational modeling. The outcome of this project will be a new understanding in the comparative physiology of oxygen transport and shunting in the kidney.Read moreRead less
Muscle fibre excitability and calcium regulation in skeletal muscle of amphibians and mammals. The fundamental role of skeletal muscle is posture and movement. Essential for this is a specialised cell structure and a complex regulation of function. This project will define key aspects of muscle structure and functional regulation crucial to developing targets for improving function under stressed states such as fatigue, disease and age.
Endogenous and environmental regulation of energy expenditure in skeletal muscle. Circadian and seasonal cycles impact on body weight; night shift workers have disrupted light-dark cycles and are predisposed to obesity. The project will investigate effects of both short and long term changes in day length on energy expenditure in skeletal muscle. Furthermore, the project will investigate mechanisms that control energy expenditure in muscle.
SKELETAL MUSCLE: REVERSIBLE TEMEPERATURE-INDUCED UNCOUPLING OF CONTRACTION FROM THE ACTIVATOR Ca2+ AND TUBULAR SYSTEM ROLES IN MUSCLE FUNCTION REGULATION. Skeletal muscles represent the largest organ in the body of vertebrates and are responsible for major functions including maintaining posture and locomotion. Skeletal muscles are also a major source of heat production. The project focuses on temperature-induced effects on the ability of the skeletal muscle to contract in warm blooded animals, ....SKELETAL MUSCLE: REVERSIBLE TEMEPERATURE-INDUCED UNCOUPLING OF CONTRACTION FROM THE ACTIVATOR Ca2+ AND TUBULAR SYSTEM ROLES IN MUSCLE FUNCTION REGULATION. Skeletal muscles represent the largest organ in the body of vertebrates and are responsible for major functions including maintaining posture and locomotion. Skeletal muscles are also a major source of heat production. The project focuses on temperature-induced effects on the ability of the skeletal muscle to contract in warm blooded animals, including marsupials, and on the complex roles played by a cellular structure unique to the muscle fibre, the tubular system, with respect to regulation of muscle function at physiological temperatures. The project will test hypotheses that will have far-reaching implications for muscle physiology, cell biology and evolutionary biology.Read moreRead less
Manipulative tests of metabolic theory. This project aims to take a new interdisciplinary approach to understanding how energy flows through individuals, populations, communities, and ecosystems. The project expects to develop a new framework for understanding the function of biological systems, bringing together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students in interdisciplinary research. The proposed research is anticipated ....Manipulative tests of metabolic theory. This project aims to take a new interdisciplinary approach to understanding how energy flows through individuals, populations, communities, and ecosystems. The project expects to develop a new framework for understanding the function of biological systems, bringing together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students in interdisciplinary research. The proposed research is anticipated to provide a means for understanding how management interventions can alter energy flows in biological systems, bringing benefits across the areas of climate change adaptation, conservation science, agriculture and aquaculture, and fisheries management.Read moreRead less
Calls and constraints: do male frogs signal direct benefits? There is international concern over recent declines and disappearances of many species of amphibians. Australia is a hotspot for declines, but causes of declines remain enigmatic. Approximately one quarter of Australia's 230 amphibian species breed in terrestrial situations, but processes such as salinity, wetland and urban developments and climate change are altering the hydrology of our landscape, and preventing the flood events nece ....Calls and constraints: do male frogs signal direct benefits? There is international concern over recent declines and disappearances of many species of amphibians. Australia is a hotspot for declines, but causes of declines remain enigmatic. Approximately one quarter of Australia's 230 amphibian species breed in terrestrial situations, but processes such as salinity, wetland and urban developments and climate change are altering the hydrology of our landscape, and preventing the flood events necessary for the completion of the lifecycle of many species. This research has important conservation implications because it examines the effects of variable moisture regimes on the physiology and reproductive behaviours of terrestrial breeding frogs.Read moreRead less
A new model for animal growth. This project aims to test and further develop a new theory for how animals grow. The new growth theory brings together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students. The proposed research is anticipated to provide a fundamentally new means for understanding how animals divide energy among growth and reproduction, paving the way for organismal allocation to these processes to be optimised by sele ....A new model for animal growth. This project aims to test and further develop a new theory for how animals grow. The new growth theory brings together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students. The proposed research is anticipated to provide a fundamentally new means for understanding how animals divide energy among growth and reproduction, paving the way for organismal allocation to these processes to be optimised by selective breeding or genetic manipulation, yielding potential benefits for aquaculture (enhanced growth) or re-introduction (enhanced reproduction).Read moreRead less
The evolution of biological scaling. This project aims to understand why so few biological traits scale proportionally with body size. In contrast to previous mechanistic studies of this longstanding question, the problem will be approached from an evolutionary viewpoint, using artificial selection to engineer animals in which biological scaling laws are either broken or enhanced. By measuring the consequences of this for fitness, the project will provide a new understanding of how organismal si ....The evolution of biological scaling. This project aims to understand why so few biological traits scale proportionally with body size. In contrast to previous mechanistic studies of this longstanding question, the problem will be approached from an evolutionary viewpoint, using artificial selection to engineer animals in which biological scaling laws are either broken or enhanced. By measuring the consequences of this for fitness, the project will provide a new understanding of how organismal size and physiology evolve in nature. The approach should provide significant benefits to our understanding of the role of genetic constraints in hindering or facilitating biological adaptation, furthering our understanding of the capacity of animals to respond to environmental change.Read moreRead less