Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new ....Inflammation as an early form of maternal-fetal signalling in pregnancy. The project aims to understand the role of inflammatory signalling in marsupial pregnancy. This project is expected to explain why inflammation, a processes normally confined to injury and infection, is a part of reproduction in live-bearing mammals. Outcomes of this project include robust measures of the capacity for, impact of, and evolution of, inflammatory signalling in marsupial pregnancy. The project will provide new knowledge about the unique biology of Australia's marsupial fauna.This project will provide significant benefits, including enhanced capacity for reproduction research in Australia, new international collaborations between Melbourne and Yale, and a new explanation for the puzzling role of inflammation in pregnancy.Read moreRead less
Unlocking telomere effects on life, death and fitness in a warming world. Few things in biology provoke such a strong desire for understanding as when adult death and fatal disease can be predicted early in life. A common factor linking early life stress, disease, ageing and time of death are telomeres, the protective regions at the end of each chromosome. This project aims to explicitly link telomere dynamics in free-living ectotherm populations with experimental approaches to advance our under ....Unlocking telomere effects on life, death and fitness in a warming world. Few things in biology provoke such a strong desire for understanding as when adult death and fatal disease can be predicted early in life. A common factor linking early life stress, disease, ageing and time of death are telomeres, the protective regions at the end of each chromosome. This project aims to explicitly link telomere dynamics in free-living ectotherm populations with experimental approaches to advance our understanding of parental and environmental effects on offspring telomeres and their effects later in life. This project will take advantage of one of the world’s longest datasets on ectotherm responses to climate to provide new knowledge of how telomeres affect fitness and the role that the environment plays.Read moreRead less