Estimating use of tobacco and nicotine products through wastewater analysis. This project aims to equip the Australian public health and security sector with a tool to accurately measure tobacco consumption in the general population. Specific human biomarkers in urine will be identified using non-target approaches and their pharmacokinetics quantified. The new data will address critical gaps in our knowledge on the population-level excretion of biomarkers for the consumption of tobacco and alter ....Estimating use of tobacco and nicotine products through wastewater analysis. This project aims to equip the Australian public health and security sector with a tool to accurately measure tobacco consumption in the general population. Specific human biomarkers in urine will be identified using non-target approaches and their pharmacokinetics quantified. The new data will address critical gaps in our knowledge on the population-level excretion of biomarkers for the consumption of tobacco and alternative nicotine products. The outcomes of this project will provide reliable, cost-effective estimates of tobacco consumption for use with wastewater-based epidemiology assessments. This will enable changes in tobacco use to be accurately evaluated for the first time and improve the efficacy of tobacco control measures.Read moreRead less
Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This proje ....Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This project will rank Australian climate-sensitive/heat attributable diseases by their current burden and projected increase under climate changes, and provide needed scientific evidence to policy-makers in the development, prioritization and implementation of current and future climate change and health adaptation strategies. Read moreRead less
Heat stress in the workplace: health burden and labour productivity loss. This project aims to estimate the economic loss of workplace heat exposure in Australia. The project will investigate the health services costs of occupational heat-related illnesses/injuries, explore the labour productivity loss and its costs resulting from heat stress at work, and estimate the benefits from a generic heat warning intervention for workplace heat prevention. Outcomes are expected to provide an overview of ....Heat stress in the workplace: health burden and labour productivity loss. This project aims to estimate the economic loss of workplace heat exposure in Australia. The project will investigate the health services costs of occupational heat-related illnesses/injuries, explore the labour productivity loss and its costs resulting from heat stress at work, and estimate the benefits from a generic heat warning intervention for workplace heat prevention. Outcomes are expected to provide an overview of national economic implications at present and in the future from effective heat stress control, assist the development of work place heat policies, and inform resource allocation to make Australian workplaces well prepared for likely increasing extremely hot weather.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100137
Funder
Australian Research Council
Funding Amount
$881,758.00
Summary
Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-fun ....Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-funded resource for integrated exposure research into the future. The archive is expected to support longitudinal and cross-sectional studies to assess trends in exposure to chemical and biological hazards in the Australian population, identify emerging hazards, and provide a scientific basis for policy and regulatory actions.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Understanding Australia by analysing wastewater during the Census 2021 . This project aims to utilise the Australian Census 2021, a unique opportunity to link exposure to chemical and biological hazards with catchment socio-demographic data via systematic wastewater analysis. The project is expected to advance our capabilities to identify emerging hazards and understand factors that affect spatiotemporal trends in hazards across Australia. Moreover, in a world first, the project aims to assess c ....Understanding Australia by analysing wastewater during the Census 2021 . This project aims to utilise the Australian Census 2021, a unique opportunity to link exposure to chemical and biological hazards with catchment socio-demographic data via systematic wastewater analysis. The project is expected to advance our capabilities to identify emerging hazards and understand factors that affect spatiotemporal trends in hazards across Australia. Moreover, in a world first, the project aims to assess chemical fate on a national level by linking sales/use with fate and release from wastewater treatment plants and assess treatment efficiency at >100 plants around Australia. The project expects to provide insight for government, wastewater managers and industry into hazards that may affect environmental and human health.Read moreRead less
Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less
Nanoparticle regulation of DNA replication and repair pathways. This project aims to understand how physical and chemical properties of nanoparticles influence how cells respond with respect to maintenance of their DNA integrity. It will use an innovative set of cross-disciplinary methodologies to link what nanoparticle parameters can lead to a benign fate in the environment. The project expects to generate new knowledge of how our ecosystem can be fundamentally impacted by nanoscale materials. ....Nanoparticle regulation of DNA replication and repair pathways. This project aims to understand how physical and chemical properties of nanoparticles influence how cells respond with respect to maintenance of their DNA integrity. It will use an innovative set of cross-disciplinary methodologies to link what nanoparticle parameters can lead to a benign fate in the environment. The project expects to generate new knowledge of how our ecosystem can be fundamentally impacted by nanoscale materials. The intended outcome of the project is to position Australia as a world leader in the manufacture of environmentally benign, advanced nano-scale materials. This is expected to provide economic benefits for Australian manufacturing while ensuring preservation of environmental health.Read moreRead less