Human capital accumulation and economic growth: A multi-country general equilibrium model. The project seeks to explain the interaction between policies that affect human capital investment and the consequences of that investment for economic growth. Specifically it aims to incorporate recent developments in the theory of economic growth, and in particular a schooling sector that produces human capital, into a multi-country and multi sector model. This will overcome limitations of the current st ....Human capital accumulation and economic growth: A multi-country general equilibrium model. The project seeks to explain the interaction between policies that affect human capital investment and the consequences of that investment for economic growth. Specifically it aims to incorporate recent developments in the theory of economic growth, and in particular a schooling sector that produces human capital, into a multi-country and multi sector model. This will overcome limitations of the current state of growth theory, associated with the high level of aggregation used in growth models - such as the effects of sector specific research subsidies research, and the effects of education subsidies on the growth of human capital specific sectors.Read moreRead less
Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm. Fizzy-Related is a gene that appears to be essential in making an ovulated egg, and it may also have an important role to play in making sperm. A mouse knockout will be generated to examine exactly how it functions; because it affects the egg number remaining in the ovary and egg quality Fizzy-Related may be eventually an important therapeutic target.
Neurotrophic factors for pelvic autonomic neurons: the role of neurturin. This project is about pelvic parasympathetic neurons, which are responsible for involuntary activities such as bladder voiding and penile erection. We are interested in the neurotrophic factors that determine survival of these neurons during early mammalian development and keep them healthy in adults. Little is known about ?parasympathetic neurotrophic factors? in general. However we have recently discovered that the prote ....Neurotrophic factors for pelvic autonomic neurons: the role of neurturin. This project is about pelvic parasympathetic neurons, which are responsible for involuntary activities such as bladder voiding and penile erection. We are interested in the neurotrophic factors that determine survival of these neurons during early mammalian development and keep them healthy in adults. Little is known about ?parasympathetic neurotrophic factors? in general. However we have recently discovered that the protein neurturin is very important in the pelvic parasympathetic system. We will determine exactly how neurturin affects pelvic neurons and how it interacts with other neurotrophic factors. Our results will fill a major gap in our knowledge of fundamental neurobiology.Read moreRead less
Modelling the APEC Digital Divide. Study of private sector motivation for the uptake of ICT is helpful in formulating regulatory and commercial responses to foster growth of competitive information-using and information-producing industries. The project will help clarify the relative benefits of production and use of ICT. Additionally, in an APEC context, analysis of the digital divide will inform policy appropriate to enhancing Australia's contribution to the region. The general purpose infor ....Modelling the APEC Digital Divide. Study of private sector motivation for the uptake of ICT is helpful in formulating regulatory and commercial responses to foster growth of competitive information-using and information-producing industries. The project will help clarify the relative benefits of production and use of ICT. Additionally, in an APEC context, analysis of the digital divide will inform policy appropriate to enhancing Australia's contribution to the region. The general purpose information technology of the Internet network is fast evolving into the enabling technology of choice for innovation and creative applications of a platform for communication and electronic transactions.Read moreRead less
Improving payments for ecosystem services efficacy. This project aims to improve the cost-effectiveness of payments for ecosystem services (PES) programs in settings where deforestation risk is high. The project introduces a field experiment in Uganda in order to determine effective methods for monitoring compliance and setting payment levels. The project intends to examine whether program impacts are undermined by displacement of deforestation and if there are poverty reduction trade-offs inher ....Improving payments for ecosystem services efficacy. This project aims to improve the cost-effectiveness of payments for ecosystem services (PES) programs in settings where deforestation risk is high. The project introduces a field experiment in Uganda in order to determine effective methods for monitoring compliance and setting payment levels. The project intends to examine whether program impacts are undermined by displacement of deforestation and if there are poverty reduction trade-offs inherent in program design. The project expects to establish the costs of foregone production from land enrolled in the program, which are largely unknown. The findings will support efforts to create low cost technologies to solve conservation challenges and assist with the efficient allocation of scarce resources for environmental protection in both Australian and international contexts.Read moreRead less
Ageing in a developing country and its effects on intra-household resource allocation. Indonesia, our largest neighbour and our third largest recipient of AID, is among the fastest-growing elderly populations in Southeast Asia. Ongoing cultural and economic change means that the traditional reliance of elderly on family support is breaking down leaving the country's social fabric vulnerable. Understanding the linkages between ageing, ill-health and the labour market responses at the household le ....Ageing in a developing country and its effects on intra-household resource allocation. Indonesia, our largest neighbour and our third largest recipient of AID, is among the fastest-growing elderly populations in Southeast Asia. Ongoing cultural and economic change means that the traditional reliance of elderly on family support is breaking down leaving the country's social fabric vulnerable. Understanding the linkages between ageing, ill-health and the labour market responses at the household level is the path to effectively intervene in the link between age and poverty and to successfully design policy that facilitates improvements in women's social status.Read moreRead less
Transcriptional and translational regulation of the neuronal protein tau. The microtubule-associated protein tau is important for brain development and performance. To perform these functions, tau levels and its variants are tightly controlled in brain cells. However, the factors that regulate tau remain largely unknown. This project will employ latest gene technologies to identify the molecular regulators of tau, for each step of the process from DNA to the protein. The outcome of this study wi ....Transcriptional and translational regulation of the neuronal protein tau. The microtubule-associated protein tau is important for brain development and performance. To perform these functions, tau levels and its variants are tightly controlled in brain cells. However, the factors that regulate tau remain largely unknown. This project will employ latest gene technologies to identify the molecular regulators of tau, for each step of the process from DNA to the protein. The outcome of this study will significantly advance our understanding of gene regulation and mechanisms for controlling protein levels and contribute to a deeper understanding of brain function during development and aging.Read moreRead less
Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide ....Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.
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The role of the transcription factor Runx2 during mammary gland development and lactation. This proposal will further our understanding of mammary gland development and lactation and the mechanisms controlling mammary cell fate decisions such as differentiation. Regulation of cell fate lies at the core of most aspects of cell biology from normal development to dysfunction such as cancer. The knowledge gleamed from this project also has the potential to make economic gains for Australia by increa ....The role of the transcription factor Runx2 during mammary gland development and lactation. This proposal will further our understanding of mammary gland development and lactation and the mechanisms controlling mammary cell fate decisions such as differentiation. Regulation of cell fate lies at the core of most aspects of cell biology from normal development to dysfunction such as cancer. The knowledge gleamed from this project also has the potential to make economic gains for Australia by increasing the profitability and ensuring the sustainability of both the dairy and meat industries. Better understanding of the mechanisms controlling mammary epithelial cell differentiation should enable augmentation of lactation such as increasing milk protein content, using marker assisted selection (of targets such as Runx2) in cattle.Read moreRead less
Elucidation of the signalling pathways during fertilization in mammals. This grant sets out to understand how the union of the sperm and egg at fertilization generates a viable embryo: this is a fundamental event in biology. We aim to understand the basic signalling pathways from the sperm which allow the egg to become an embryo and are known to influence embryo quality. They are therefore important in our understanding of what constitutes a healthy early start to life. Australia also has econom ....Elucidation of the signalling pathways during fertilization in mammals. This grant sets out to understand how the union of the sperm and egg at fertilization generates a viable embryo: this is a fundamental event in biology. We aim to understand the basic signalling pathways from the sperm which allow the egg to become an embryo and are known to influence embryo quality. They are therefore important in our understanding of what constitutes a healthy early start to life. Australia also has economic interests in understanding the reproductive process in aiding breeding programs for commercially important livestock and endangered species and contraception programs for pest populations. Read moreRead less