I am a clinician-scientist with a focus on basic and translational research in male reproductive physiology and health disorders, notably infertility, contraception and androgen action.
Regulation Of Immune Responses In The Adult Testis And Male Reproductive Health
Funder
National Health and Medical Research Council
Funding Amount
$637,857.00
Summary
This project investigates the main inflammatory cell, the macrophage, in male fertility and reproductive health. These studies investigate the macrophages found in the testes and the regulation of their functions required to protect and support the developing sperm. Understanding these processes will lead to new methods for treating male infertility, chronic pain and reproductive tract infections, as well as broader understanding of inflammatory disease, transplantation and autoimmunity.
Hormonal Responsive Coding And Non-coding Genes In Penile Differentiation And Hypospadias
Funder
National Health and Medical Research Council
Funding Amount
$835,182.00
Summary
Hypospadias, a failure of the correct formation of the penis, is the second-most common birth defect, occurring in around 1% of boys. It causes distress to both newborn and parents, requiring surgical intervention, and is a burden of cost and is a risk to the child. Furthermore, it is frequently associated with other abnormalities. We have a novel model in which we can induce penis abnormalities and define the link between hormonal exposures and defective penis differentiation.
Women's Hormones And Health Across The Adult Life Span
Funder
National Health and Medical Research Council
Funding Amount
$951,005.00
Summary
Sex hormones are important in younger and older women’s health. However, normal levels of sex hormones for women of different ages and the extent to which sex hormones are associated with common health outcomes are yet to be established. These issues will be systematically studied in comprehensive, community-based studies of younger and older Australian women. The findings will be immediately translated into clinical practice guidelines and community education.
The Role Of Androgens In Cardiovascular Repair And Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$464,468.00
Summary
Increasing evidence indicates that the heart and blood vessels are able to repair themselves in response to disease. Recent evidence suggests that in men, male sex hormones(e.g. testosterone) may play an important role in helping repair blood vessels. As men get older, their testosterone levels get progressively lower - this lead to impairment of vascular repair mechanisms with aging. We will study the effects of androgens on repair and regeneration of the vasculature.