Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775725
Funder
Australian Research Council
Funding Amount
$465,000.00
Summary
Molecular separation and characterisation - A facility for advanced mass spectroscopy and chromatography. Characterising molecular composition is a basic need for the progress of many sciences. It is used to examine traditional and modern medicinal chemistry, bio-active peptides, molecular modulation of chemical properties, markers of disease and system status, and can also be used to elucidate molecular mechanisms and interactions in a system. This can only be achieved through precise measureme ....Molecular separation and characterisation - A facility for advanced mass spectroscopy and chromatography. Characterising molecular composition is a basic need for the progress of many sciences. It is used to examine traditional and modern medicinal chemistry, bio-active peptides, molecular modulation of chemical properties, markers of disease and system status, and can also be used to elucidate molecular mechanisms and interactions in a system. This can only be achieved through precise measurement using the frontier technologies described in this grant. This proposal ensures international competitiveness on a broad front, and supports highest level research training and bio/chemical/medical research in several priority research areas. Read moreRead less
Special Research Initiatives - Grant ID: SR0354560
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
AUSTRALIAN RESEARCH NETWORK IN ANALYTICAL SCIENCE (ARNAS). The initiative will provide the foundations for the establishment of an Australian Research Network in Analytical Science (ARNAS), which will bring together fundamental researchers and practitioners working in quantitative chemical analysis and related areas. ARNAS will provide national coordination of research in analytical science, coverage of the newest developments, pooling of expertise and research facilities and resources, and rap ....AUSTRALIAN RESEARCH NETWORK IN ANALYTICAL SCIENCE (ARNAS). The initiative will provide the foundations for the establishment of an Australian Research Network in Analytical Science (ARNAS), which will bring together fundamental researchers and practitioners working in quantitative chemical analysis and related areas. ARNAS will provide national coordination of research in analytical science, coverage of the newest developments, pooling of expertise and research facilities and resources, and rapid dissemination of outcomes. ARNAS will significantly advance the national research agenda for analytical science by improving awareness of research activities and expertise, providing enhanced education and opportunities for the next generation of analytical scientists, and by stimulating new international collaborations.Read moreRead less
Multiplexed bio-imaging mass spectrometry. This project aims to develop technology for simultaneous three-dimensional imaging of trace elements and molecules in biological tissues. This technology is an essential analytical and diagnostic advance to uncover latent mechanistic biology and will reveal subtle metabolic interactions between cells. The project will use laser ablation-inductively coupled plasma-mass spectrometry and lanthanide-conjugated probes to map the zinc metabolic pathway in the ....Multiplexed bio-imaging mass spectrometry. This project aims to develop technology for simultaneous three-dimensional imaging of trace elements and molecules in biological tissues. This technology is an essential analytical and diagnostic advance to uncover latent mechanistic biology and will reveal subtle metabolic interactions between cells. The project will use laser ablation-inductively coupled plasma-mass spectrometry and lanthanide-conjugated probes to map the zinc metabolic pathway in the ageing mouse brain. It is expected to result in a complete imaging solution for quantitative spatial determination of all important elements, co-factors, metabolites and other functional molecules to investigate metabolic pathways which current technologies find difficult or impossible to track. Ultimately this technology is expected to underpin investigations of diseases where trace metal and chemical species dysfunction is implicated.Read moreRead less
Characterization of metabolic networks in a microbial pathogen. New methods are needed to understand complex cellular processes such as metabolism. This proposal will support the development of methods in metabolite profiling and flux analysis that provide a global view of metabolic networks in cells and complement other profiling approaches, such as proteomics and transcriptomics. The development of these approaches (collectively termed Systems Biology) is essential for maintaining Australia sc ....Characterization of metabolic networks in a microbial pathogen. New methods are needed to understand complex cellular processes such as metabolism. This proposal will support the development of methods in metabolite profiling and flux analysis that provide a global view of metabolic networks in cells and complement other profiling approaches, such as proteomics and transcriptomics. The development of these approaches (collectively termed Systems Biology) is essential for maintaining Australia science at the forefront of international efforts (National Research Priority 3; Breakthrough science). This project will also directly contribute to our understanding of metabolism of an important human pathogen and provide training to young Australian scientists.Read moreRead less
Novel semio-chemical approach to control the Australian Sheep Blowfly . The Australian Federal Government through the 'Smart Farming' initiative highlights the need for improved multidisciplinary measures in order to remain at the global forefront of the invention and adoption of technology. This multidisciplinary project (entomology, biotechnology, analytical chemistry and genomics) will rapidly inform the management of fly strike on an important Australian resource merino sheep. This will bui ....Novel semio-chemical approach to control the Australian Sheep Blowfly . The Australian Federal Government through the 'Smart Farming' initiative highlights the need for improved multidisciplinary measures in order to remain at the global forefront of the invention and adoption of technology. This multidisciplinary project (entomology, biotechnology, analytical chemistry and genomics) will rapidly inform the management of fly strike on an important Australian resource merino sheep. This will build the key biochemical data in order to develop a novel fly lure technology (at scale) to be used on farm delivering national benefit through improved animal welfare and safety considerations for producers, and will establish the best approach to disseminate this scientific information to stakeholders such as farmers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100213
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Advanced fluorescence characterisation facility. Fluorescence is the emission of light by a substance that has absorbed light of a different wavelength. Fluorescence techniques and fluorescent molecules have enabled a great many of the most important advances in biology, chemistry and medicine in recent decades. This facility will support a wide range of research projects using or exploring fluorescence and luminescence. The research supported will underpin advances in diverse scientific fields.
Multi-Colour Electrogenerated Chemiluminescence. This project plans to explore a new approach to chemical detection, in which molecules that emit different coloured light can be selectively switched on or switched off via the applied electrode potential. This would enable unprecedented numbers of simultaneous (multiplexed) detection events for time-critical analytical applications such as clinical diagnostics, environmental monitoring and biodefense assays. These assays could be performed on low ....Multi-Colour Electrogenerated Chemiluminescence. This project plans to explore a new approach to chemical detection, in which molecules that emit different coloured light can be selectively switched on or switched off via the applied electrode potential. This would enable unprecedented numbers of simultaneous (multiplexed) detection events for time-critical analytical applications such as clinical diagnostics, environmental monitoring and biodefense assays. These assays could be performed on low-cost microfluidic platforms operated by portable consumer devices such as mobile phones. Expected outcomes may provide new capabilities in rapid screening for disease biomarkers, environmental pollutants and bioterrorism agents, using simple, low-cost, portable instrumentation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989125
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest. The proposed integrated facility will strongly support collaborative research in areas of high national priority. These are environmental sustainability, development of new materials and designing molecules of therapeutic value on the basis of better understanding the relevant biological processes. This support will lead to maximizing the outcomes of numerous ....Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest. The proposed integrated facility will strongly support collaborative research in areas of high national priority. These are environmental sustainability, development of new materials and designing molecules of therapeutic value on the basis of better understanding the relevant biological processes. This support will lead to maximizing the outcomes of numerous projects already funded by the Australian Research Council which require accurate and highly sensitive analysis. This will improve the cost effectiveness of research funding and will further strengthen the outstanding reputation of Australia science worldwide.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100215
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Molecular spectroscopic 2D and 3D imaging systems at sub-micron spatial resolution. High-resolution chemical imaging systems are powerful tools for understanding the detailed make-up of a wide range of important high-tech materials. They allow researchers to map the distribution and form of separate chemical components, as well as the interactions between them. This information is critical for the design and formulation of the next generation of pharmaceuticals and drug delivery systems. It will ....Molecular spectroscopic 2D and 3D imaging systems at sub-micron spatial resolution. High-resolution chemical imaging systems are powerful tools for understanding the detailed make-up of a wide range of important high-tech materials. They allow researchers to map the distribution and form of separate chemical components, as well as the interactions between them. This information is critical for the design and formulation of the next generation of pharmaceuticals and drug delivery systems. It will allow the investigators to develop new biomedical materials for implants and prostheses, while new surface coatings will also improve the performance of aerospace structures. Novel sensors and process monitoring techniques will be used to develop new medical diagnostics and to control the quality of pharmaceuticals production.Read moreRead less