Identifying Drug Targets In Microbial Pathogens Using Metabolomics
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
Infectious diseases such as malaria, leishmaniasis and tuberculosis cause enormous morbidity and mortality worldwide. This proposal will utilize advanced analytical and genetic approaches to study the metabolism of the respective protozoan and bacteria agents as well as the associated host responses. These approaches will be used to develop novel therapeutic approaches and new analytical tools that can be applied to other infectious diseases
Understanding The Complexity Of Antigen Presentation
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
I have developed and established the use of mass spectrometry to identify and quantitate ligands of antigen presenting molecules to understand the breadth of immune responses in a variety of human disease states including autoimmunity, cancer, infection and allergy. By embedding the technology in disease focussed research programs I will define the molecular bases of these diseases and the important immunological targets that will provide new avenues for therapeutic development and vaccines.
Lipidomics Of Obesity, Type 2 Diabetes And Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$727,765.00
Summary
Obesity, type 2 diabetes and cardiovascular disease are major health problems in Australia and result in many tens of thousands of deaths each year. Changes in our metabolism lead to an imbalance in lipids (fats) circulating in our blood (dyslipidemia) which contributes to the disease process. This project will characterise these changes in circulating lipids to develop new tests to identify those at greatest risk of disease so that early treatment can be provided.