Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237908
Funder
Australian Research Council
Funding Amount
$637,000.00
Summary
Mass Spectrometry Instrumentation for Therapeutic Lead Discovery. Drug discovery is reliant on the application of basic research and advanced technologies to obtain solutions to human suffering caused by diseases. This application seeks funding to support the installation of state-of-the-art mass spectrometry instrumentation at Griffith University and the University of Melbourne. The requested instrumentation will enhance high quality collaborative research programs in drug discovery and eradica ....Mass Spectrometry Instrumentation for Therapeutic Lead Discovery. Drug discovery is reliant on the application of basic research and advanced technologies to obtain solutions to human suffering caused by diseases. This application seeks funding to support the installation of state-of-the-art mass spectrometry instrumentation at Griffith University and the University of Melbourne. The requested instrumentation will enhance high quality collaborative research programs in drug discovery and eradicate significant deficiencies in research infrastructure at both institutions. Access to state-of-the-art mass spectrometry instrumentation will markedly improve our international competitiveness across a broad range of biological and chemical science disciplines.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989336
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are ....The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are critical for the competitiveness of Australian industry, national productivity and economic growth. This application seeks to provide a facility for multidisciplinary scientific development that will enhance academic-industrial collaboration. This will position SA research community for scientific breakthroughs that benefit the Australian community.Read moreRead less
Synthesis and Characterisation of Encoded Hybrid Polymer/Gold Nanoparticles for Application in Bioassays. Bioassays are the cornerstone of in vitro diagnostic and biomedical research. This proposal will significantly contribute to these areas, by targeting an emerging technology that is crucial for their future development. The hybrid nanoparticles described in this project have the potential to replace conventional detection strategies that are currently used for bioassays. In doing so, they sh ....Synthesis and Characterisation of Encoded Hybrid Polymer/Gold Nanoparticles for Application in Bioassays. Bioassays are the cornerstone of in vitro diagnostic and biomedical research. This proposal will significantly contribute to these areas, by targeting an emerging technology that is crucial for their future development. The hybrid nanoparticles described in this project have the potential to replace conventional detection strategies that are currently used for bioassays. In doing so, they should provide significant advantages over conventional detection strategies. These advantages include increased sample throughput and conservation of biological samples, which makes possible the acceleration of patient diagnosis and drug discovery. Read moreRead less
Modifying and Improving Porous Sol-Gel Materials for Water Purification. XeroCoat is commercialising nanotechnology research out of UQ's Physics department. XeroCoat has received much local and international interest in its signature product 'XeroCoat'. The company is rapidly expanding and has established new research facilities with production facilities to be set-up. This will result in high technology, employment growth for Australia. Links with Flinders could see expansion into SA. The c ....Modifying and Improving Porous Sol-Gel Materials for Water Purification. XeroCoat is commercialising nanotechnology research out of UQ's Physics department. XeroCoat has received much local and international interest in its signature product 'XeroCoat'. The company is rapidly expanding and has established new research facilities with production facilities to be set-up. This will result in high technology, employment growth for Australia. Links with Flinders could see expansion into SA. The company operates in 'Sol-Gel' nanotechnology, which has huge global, academic and commercial interest. However in Australia this technology has only been serviced by Flinders, ANSTO and ANSTO's spin-out company Ceramisphere. The project will help to build a new Australian high tech industry in sol-gel nanotechnology.Read moreRead less
Biochemistry of tropoelastin and elastin: the molecular architecture of elastic fibre assembly. Elastin destruction drives the progression of emphysema, a major component of chronic obstructive pulmonary disease which is a major cause of death. Loss of elastin leads to profound blockage of arteries. If we are to treat these problems we need to know how to make and repair elastin. This research will enable us to discover how elastin is constructed and define its interacting partners. We will lear ....Biochemistry of tropoelastin and elastin: the molecular architecture of elastic fibre assembly. Elastin destruction drives the progression of emphysema, a major component of chronic obstructive pulmonary disease which is a major cause of death. Loss of elastin leads to profound blockage of arteries. If we are to treat these problems we need to know how to make and repair elastin. This research will enable us to discover how elastin is constructed and define its interacting partners. We will learn how to make tissue components found in parts of the body that expand and contract such as the arteries, lung and skin. We will learn about the molecular mechanisms of elastin assembly and cell interactions, which gives us the core molecular toolkit to repair elastin tissue.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454209
Funder
Australian Research Council
Funding Amount
$126,326.00
Summary
A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing. The carbohydrate moiety of glycoconjugates plays an important role in their function and metabolism. Advances in glycan analytical and oligosaccharide sequencing techniques offer tremendous potential for the application of glycobiology to biotechnology, cell biology and medicine. This application aims to establish a Glycobiology Facility dedicated to glycoconjugate analysis and oligosaccharide sequencing. Funds a ....A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing. The carbohydrate moiety of glycoconjugates plays an important role in their function and metabolism. Advances in glycan analytical and oligosaccharide sequencing techniques offer tremendous potential for the application of glycobiology to biotechnology, cell biology and medicine. This application aims to establish a Glycobiology Facility dedicated to glycoconjugate analysis and oligosaccharide sequencing. Funds are requested for state of the art HPLC equipment, associated equipment and reagents for glycan purification/labelling, and a staff member, that are all essential to establish this technology in Australia. The Facility will support $25 million of existing research; approximately half of which is derived from ARC.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561169
Funder
Australian Research Council
Funding Amount
$188,000.00
Summary
Facility for multidimensional fractionation of complex biological mixtures. Acquisition of multidimensional fractionation equipment will allow researchers to separate proteins from complex mixtures, and to compare whole protein profiles of multiple samples. This will permit correlation of specific protein changes associated with infection or disease, a major focus of post-genomic programs of research. The equipment will also provide identification of the key differentiating proteins using mini ....Facility for multidimensional fractionation of complex biological mixtures. Acquisition of multidimensional fractionation equipment will allow researchers to separate proteins from complex mixtures, and to compare whole protein profiles of multiple samples. This will permit correlation of specific protein changes associated with infection or disease, a major focus of post-genomic programs of research. The equipment will also provide identification of the key differentiating proteins using minimal material. Numerous world-class projects and researchers will be able to move more rapidly and reliably from crude cell extracts to identifiable markers, and maintain their competitive positions the recognition of key targets in drug design, disease diagnosis and vaccine development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775481
Funder
Australian Research Council
Funding Amount
$304,000.00
Summary
X-ray Molecular Structure Elucidation Facility (MSEF). X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art re ....X-ray Molecular Structure Elucidation Facility (MSEF). X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art research and training facilities.Read moreRead less
Establishing In-Depth Understanding of Molecular Degradation Processes in Acrylic Based Polymer Coil-Coatings for Domestic Roofing Applications. The national benefit is multipronged: (i) BlueScope Steel will maintain its technology leadership through continued innovation by taking advantage of the scientific insights that the project delivers for the introduction of next generation long lasting coil coatings for steel, based on an environmentally friendly production processes. (ii) The applicati ....Establishing In-Depth Understanding of Molecular Degradation Processes in Acrylic Based Polymer Coil-Coatings for Domestic Roofing Applications. The national benefit is multipronged: (i) BlueScope Steel will maintain its technology leadership through continued innovation by taking advantage of the scientific insights that the project delivers for the introduction of next generation long lasting coil coatings for steel, based on an environmentally friendly production processes. (ii) The application of mass spectrometry for the analysis of polymer degradation has been pioneered by the CI and BlueScope Steel. The project will demonstrate the power of this technique and secure Australia's place at the forefront of molecular polymer degradation research. (iii) The project has a strong educational component, training a PhD student at the interface of application and fundamental research.Read moreRead less
Fundamentals of the Performance Chemistry of Water-borne Acrylic Polymer based Surface Coatings for Pre-painted Steel Employed in Domestic Roofing Applications. The proposed project will systematically investigate the structure-performance relationships of acrylic emulsion based surface coatings and provide a detailed understanding of their degradation mechanisms. The improved understanding of these coatings will lead to the development of an optimum coating for steel roofs with extremely high d ....Fundamentals of the Performance Chemistry of Water-borne Acrylic Polymer based Surface Coatings for Pre-painted Steel Employed in Domestic Roofing Applications. The proposed project will systematically investigate the structure-performance relationships of acrylic emulsion based surface coatings and provide a detailed understanding of their degradation mechanisms. The improved understanding of these coatings will lead to the development of an optimum coating for steel roofs with extremely high durability and resistance against degradation and gloss loss in typical tropical and sub-tropical Australian climates.Read moreRead less